Concentration of anti-Müllerian hormone in dairy heifers is positively associated with productive herd life

Jimenez-Krassel, Fermin; Scheetz, Danielle M.; Neuder, L.; Ireland, J. J.; Pursley, J.R.; Smith, George W.; Tempelman, Robert J.; Ferris, T.A.; Roudebush, William E.; Mossa, F.; Lonergan, P.; Evans, A.C.O.; Ireland, James J.

doi:10.3168/jds.2014-8130

Cited by 95 publications

(92 citation statements)

References 37 publications

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“…In this study, dairy cows with a low AFC had a lower conception rate to first AI, greater number of AI to conceive and higher calving interval compared with cows with an intermediate or high AFC . Like our finding for dairy cows with low AMH as a heifer (Jimenez-Krassel et al 2015), overall pregnancy rate was lower for the dairy cows with a low compared with a high AFC . Another study shows that dairy cows with high AMH had greater pregnancy rates and lower incidence of pregnancy loss between days 30 and 65 of gestation (Ribeiro et al 2014).…”

Section: Fertilitysupporting

confidence: 36%

“…4). Also, removal rate for poor reproductive performance compared with all other reasons for culling was greater for Q1 compared with Q2, Q3 and Q4 cows combined during the first lactation (Jimenez-Krassel et al 2015). This study, albeit conducted on a limited number of animals, indicates that a single determination of AMH concentrations in young adult Holstein heifers is predictive of their future herd longevity.…”

Section: Longevitymentioning

confidence: 91%

“…In addition, cross-sectional studies using older cows may be biased by previous removal (culling) of individuals from the herd with a relatively low AFC or AMH. Nevertheless, combined results (Cushman et al 2009, Jimenez-Krassel et al 2015, Martinez et al 2016 imply that fertility is suboptimal in cows with low AMH concentrations as heifers and in cows with low AMH or a low AFC compared with herd mates with higher AMH concentrations or a higher AFC.…”

Section: Fertilitymentioning

confidence: 99%

“…Thus, we tested the hypothesis that cattle with the lowest AMH concentrations have suboptimal fertility and are removed from a herd for poor reproductive performance at a greater rate and therefore have a shorter productive herd life (time in herd after calving) compared with age-matched herd mates with higher AMH (Jimenez-Krassel et al 2015). A single AMH measurement was made in 281, 11-to 15-month-old Holstein heifers.…”

Section: Longevitymentioning

confidence: 99%

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Anti-Müllerian Hormone (AMH) and fertility management in agricultural species

Mossa¹,

Jimenez-Krassel²,

Scheetz³

et al. 2017

Reproduction

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A reliable, easy to assess marker for fertility in agricultural species would be highly desirable and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes recent findings concerning AMH and its role in fertility management, mainly in cattle. It focuses on (1) alterations in circulating AMH concentrations from birth to puberty and during estrous cycles; (2) correlation of circulating AMH concentrations with ovarian follicle numbers and ovarian reserve; (3) factors that impact circulating AMH concentrations; (4) use of AMH as a predictor of fertility. Circulating AMH concentrations can be easily and reliably measured with a single blood sample in adult cattle because AMH varies minimally during the estrous cycle and is repeatable across multiple cycles. Circulating AMH concentrations are positively associated with several measures of fertility. Dairy heifers with low compared with higher AMH concentrations subsequently had lower pregnancy rates, higher probability of being culled after birth of their first calf and shorter herd longevity. Also, AMH is predictive of response to superovulation in cattle and sheep. Several factors contribute to the variability in AMH concentrations among individuals; for example, beef cattle have higher AMH than dairy cattle. Nutritional imbalances, disease and endocrine disruptors during fetal life may negatively program the size of the ovarian reserve and consequently serum AMH concentrations and potential fertility in adulthood. We conclude that AMH may be a predictor of fertility and herd longevity in cattle, whereas in sheep and other farm species, the potential association between AMH and reproductive performance remains largely unexplored. Free Italian abstract: An Italian translation of this abstract is freely available at http://www.reproduction-online.org/content/154/1/ R1/suppl/DC1. Reproduction (2017) 154 R1-R11

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Section: Fertilitysupporting

confidence: 36%

Section: Longevitymentioning

confidence: 91%

Section: Fertilitymentioning

confidence: 99%

Section: Longevitymentioning

confidence: 99%

See 2 more Smart Citations

Anti-Müllerian Hormone (AMH) and fertility management in agricultural species

Mossa¹,

Jimenez-Krassel²,

Scheetz³

et al. 2017

Reproduction

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“…The plasma levels of AMH have been associated with the number of AFs in both taurine and zebu cattle (Jimenez‐Krassel et al., ; Modina et al., ). In this study, although the mRNA levels of AMH were similar in granulosa and cumulus cells from low and high AF cows, we observed that granulosa cells of Nelore cows with high AF had increased mRNA expression of AMHR2a compared with low AF cows.…”

Section: Discussionmentioning

confidence: 99%

Molecular characteristics of granulosa and cumulus cells and oocyte competence in Nelore cows with low and high numbers of antral follicles

Rosa

Marinho

Rosa

et al. 2018

Reprod Domestic Animals

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The aims of this study were to investigate whether the number of antral follicles (AF) in the ovaries of Nelore cows is influenced with the developmental competence of oocytes to reach the blastocyst stage and to quantify the mRNA abundance of genes associated with folliculogenesis and oogenesis in granulosa and cumulus cells. A total of 168 cows were distributed into two experimental groups according to the number of AF, low (≤31) and high AF (≥92), which were determined based on the mean number of AF (61.14) ± SD (30.43). Granulosa and cumulus cells were used to assess the mRNA expression of 16 genes. Cumulus cells from cows with low AF had higher mRNA expression of genes involved in meiosis resumption (NPR-2, NPR-3) and cumulus cell expansion (FGF10), as well as a transcription factor involved in the regulation of oocyte maturation and cell proliferation (STAT3). Conversely, granulosa cells from females with high AF had higher expression of PGR and AMHR2a, which are involved in meiosis resumption and cumulus cell expansion. Cumulus-oocyte complexes (COCs) were collected from 356 cows with low and high AF populations to evaluate embryo development. Cleavage and blastocyst rates did not differ between the groups. In conclusion, our findings revealed that genes involved in folliculogenesis and oogenesis are differently expressed in cumulus and granulosa cells of cows having low and high numbers of AF. These molecular differences suggest that the regulation of oocyte maturation, meiotic resumption and cumulus expansion may be influenced by the number of AFs. However, the variations in gene expression were not associated with in vitro oocyte developmental competence to reach the blastocyst stage, which confirms that oocytes from Nelore cows with low and high numbers of AF are similarly able to mature, regulate the fertilization process and support pre-implantation embryo development.

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