Concentration of ciprofloxacin in non-functional gallbladder mucosa after single dose intravenous administration

Sayek, I; Kaynaroğlu, Volkan; Scholl, H

doi:10.1007/bf01641434

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…Also, the glycuronic acid conjugate of ciprofloxacin accounted for approximately 30% of the total ciprofloxacin excreted in bile. Saye et al [133] administered a single dose of 300 mg ciprofloxacin to patients undergoing elective cholecystectomy. The gallbladders were removed 30, 60 or 120 min after the end of the infusion.…”

Section: Ciprofloxacinmentioning

confidence: 99%

Biliary Excretion of Antimicrobial Drugs

Karachalios

Charalabopoulos²

2002

Chemotherapy

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The development of drugs able to prevent and cure bacterial infections is one of the 20th century’s major contributions to human longevity and quality of life. Antibacterial agents are among the most commonly prescribed drugs of any kind worldwide. Used appropriately, these drugs are lifesaving. To eliminate an infection as rapidly as possible, a sufficient concentration of the drug(s) chosen must reach the site of infection. Serum/tissue concentration is a result of various parameters such as absorption, excretion, protein binding and metabolic inactivation. Biliary excretion is an important route for the elimination of some drugs and drug metabolites in humans. Thus, drugs with a high bile concentration are indicated for the treatment of gallbladder infectious diseases. We present a review of a large number of antimicrobial agents most commonly used in daily clinical practice, with regard to their biliary excretion.

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Section: Ciprofloxacinmentioning

confidence: 99%

Biliary Excretion of Antimicrobial Drugs

Karachalios

Charalabopoulos²

2002

Chemotherapy

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Antibiotics in the Biliary Tract: A Review of the Pharmacokinetics and Clinical Outcomes of Antibiotics Penetrating the Bile and Gallbladder Wall

Thabit

2020

Pharmacotherapy

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Biliary tract infections (BTIs), including cholangitis and cholecystitis, are common causes of bacteremia. Bacteremic BTIs are associated with a mortality rate of 9–12%. The extent to which antibiotics are excreted in the bile and the ratio of their exposure to the minimum inhibitory concentration of the infecting organism are among the important factors for the treatment of BTIs. This review updates health care professionals on the distribution of antibiotics in the common bile duct, gallbladder, and gallbladder wall. Antibiotic efficacy in treating BTIs based on the latest available clinical studies is also discussed. The efficacy and pharmacokinetics of 50 antibiotics are discussed. Overall, most antibiotic classes exhibit biliary penetration that translates into clinical efficacy. Only seven antibiotics (amoxicillin, cefadroxil, cefoxitin, ertapenem, gentamicin, amikacin, and trimethoprim/sulfamethoxazole) had poor biliary penetration profiles. Three antibiotics (ceftibuten, ceftolozane/tazobactam, and doripenem) had positive clinical outcomes despite the lack of pharmacokinetic studies on their penetration into the biliary tract. Conflicting efficacy data were reported for ampicillin despite adequate biliary penetration, whereas conflicting pharmacokinetic data were reported with cefaclor and moxifloxacin. Even in the absence of supportive clinical studies, antibiotics with good biliary penetration profiles may have a place in the treatment of BTIs.

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Concentration of ciprofloxacin in non-functional gallbladder mucosa after single dose intravenous administration

Cited by 2 publications

References 4 publications

Biliary Excretion of Antimicrobial Drugs

Biliary Excretion of Antimicrobial Drugs

Antibiotics in the Biliary Tract: A Review of the Pharmacokinetics and Clinical Outcomes of Antibiotics Penetrating the Bile and Gallbladder Wall

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