Concentration of Fatty Acid Ethyl Esters in Hair of Alcoholics: Comparison to Other Biological State Markers and Self Reported-Ethanol Intake

Wurst, Friedrich Martin; Alexson, Stefan E.H.; Wolfersdorf, Manfred; Bechtel, G.; Förster, Stephan; Alling, Christer; Aradóttir, Steina; Jachau, Katja; Huber, Peter; Allen, John P.; Auwärter, Volker; Pragst, F.

doi:10.1093/alcalc/agh005

Cited by 96 publications

(67 citation statements)

References 39 publications

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“…However, there may be an increased role for the quantitative estimation of cannabis usage based on hair analysis. This potentially allows more precise and reliable estimation of recent historical use of cannabis, and had been developed for various substances, most recently alcohol (Wurst et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Is cannabis an anti-antipsychotic? The experience in psychiatric intensive care

Isaac

Holloway

2005

Hum. Psychopharmacol. Clin. Exp.

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Section: Discussionmentioning

confidence: 99%

Is cannabis an anti-antipsychotic? The experience in psychiatric intensive care

Isaac

Holloway

2005

Hum. Psychopharmacol. Clin. Exp.

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“…Etanol ve serbest yağ asitleri, trigliseridler, lipoproteinler veya fosfolipitlerin varlığında yağ asidi etil esterleri karaciğerde yağ asidi etil ester sentaz tarafından oluşturulmakta, ayrıca bu enzimin saç köklerinde de bulunduğu bildirilmektedir. 54,55 Yağ asit etil esterlerinin alkole bağlı organ hasarıyla ilişkili bulunması, ilgi çekici olarak nitelendirilmiştir. Kandaki yağ asidi etil esterlerinin, aktif alkol alımının veya alkol alımının tamamlanmasından sonra en az 24 saat geçtiğinin bir belirteci olarak kullanılabileceği öne sürülmüştür.…”

Section: Alkolün Kötüye Kullaniminin Saptanmasiunclassified

Incorporation of Drug and Substances in Hair

Mutlu¹,

Aşıcıoğlu²

2018

Turkiye Klinikleri J Foren Sci Leg Med

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aç, homojen bir yapıya sahip gibi görünse de aslında oldukça karmaşık olan biyolojisi kısmen anlaşılmıştır.1 Memelilerde saç; protein (%65-95), su (%15-35), lipit (%1-9) ve minerallerden (<%1) oluşan deri eklerinden biridir. Saç şaftında korteksi çevreleyen bir kütikül bulunduğu gibi, bazı saç tiplerinde santral medullayı çevreleyen ilave bir kütikülde bulunmaktadır.2 Saç apokrin, sebase ve ter bezleriyle yakın ilişkide olan cildin A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Saç; ilaç; birikim; kötüye kullanım A AB BS S T TR RA AC CT T In recent years hair has become a fundamental biological specimen, alternative to the usual samples blood and urine, for drug testing in the fields of forensic toxicology, clinical toxicology and clinical chemistry. Analytical results of drugs of abuse in hair provide useful information on chronic drug use. They are valuable to presume the history and severity of individual drug abuse and to provide supplementary information on drug use to facilitate interpretation of urine drug analysis. Hair testing has larger detection window. The sample collection is non-invasive. Another advantage of hair samples is that it can be stored at room temperature and do not need to be analyzed quickly after they are collected. Hair analysis is also used for detection of gestational drug exposure, doping control and detection of alcohol abuse. It has been reported that drugs are incorporated into hair by binding to such intracellular components as melanins, lipids, and proteins. It has been proposed that drugs and substances can enter into hair during at least 3 stages: from the blood during hair formation, from sweat and sebum, and from external environment. The aim of this review is to document and discuss the mechanisms of drug or substance accumulation in hair and its influencing factors, application of hair analysis.

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“…It can be used in a transparent way to generate the likelihood ratio that associates any particular value of the metric observed in a questioned sample with the probability that H is true. The application of ROC curves in other areas of forensic science has been discussed in a number of papers [47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] , and the reader is encouraged to review this literature if unfamiliar with the method.…”

Section: Hypothesis Testingmentioning

confidence: 99%

Validation Strategies for Microbial Forensic Analysis

Velsko¹

2012

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The validation of the probative value of microbial forensic techniques is a critical aspect of research and development that requires careful planning and a sound conceptual framework. This paper outlines a particular approach to the validation of certain types of forensic methods that naturally generates statistical measures of the relevance and weight of the scientific evidence derived from them. The suggested approach is based on the likelihood ratio interpretation of Federal Rules of Evidence 401 and 402 and allows measurement evidence to be to be presented in a format that resembles the forensic "gold standard" -human DNA typing. Examples of specific genetic and chemical and physical analysis methods are used to illustrate how this general strategy can be applied. This approach also provides a natural interpretation of the notion of "preliminary validation" that has been proposed in the literature.

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Concentration of Fatty Acid Ethyl Esters in Hair of Alcoholics: Comparison to Other Biological State Markers and Self Reported-Ethanol Intake

Abstract: The data suggest that C(FAEE) is a potentially valuable marker of chronic intake of high quantities of ethanol. Furthermore, the results indicate that a reasonable and provisional FAEE cut-off to distinguish between social/moderate and heavy drinking/alcoholism in hair is 0.4 ng/mg.

Cited by 96 publications

References 39 publications

Is cannabis an anti-antipsychotic? The experience in psychiatric intensive care

Is cannabis an anti-antipsychotic? The experience in psychiatric intensive care

Incorporation of Drug and Substances in Hair

Validation Strategies for Microbial Forensic Analysis

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