Concentration of NK cells after β-glucan and vitamin D supplementation in patients with diabetic retinopathy

Richter, Josef; Pohorska, Jitka; Zahradnicka, Martina; Vlastimil, Král; Stiborová, I; Lucie, Dobiasova Rajnohova; Větvička, Václav

doi:10.1007/s12223-020-00789-2

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Patients who are at high risk of developing diabetes may benefit from vitamin D supplementation. With vitamin D plus beta-glucan treatment, there is a significant improvement in entire patient health status, which may include mental health, physical health, lipid metabolism, leptin levels, and inflammatory state [55]. Patients who may have low risk or recent onset of type 1 diabetes mellitus may benefit from nicotinamide (vitamin B3), which has been shown to have protective effects and capabilities against the destruction of pancreatic beta cells [56].…”

Section: (A) Functional Foodsmentioning

confidence: 99%

Impact of Nutraceuticals on Type 1 and Type 2 Diabetes Mellitus-Induced Micro- and Macrovasculopathies

Mabena,

Fasemore,

Nkomozepi

2023

Applied Sciences

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Diabetes mellitus (DM), one of the most serious non-communicable diseases, has long-term negative effects on the healthcare system due to its microvascular and macrovascular manifestations, which can be fatal if left untreated. Nutraceuticals, on the other hand, are alternative therapy choices of orally consumed natural food ingredients applicable in the management of several diseases, including diabetes mellitus. Through their antioxidant capabilities and bioactive components, nutraceuticals have been clinically demonstrated to be effective in preventing a number of ailments, including cancer, diabetes, heart disease, and kidney problems. Flavonoids, which are categorized as phytochemicals, are present in several of these nutraceuticals. Cocoa, one of the flavanols engaged in the treatment of diabetes mellitus, provides an additional non-pharmaceutical intervention in the management of diabetes mellitus, which, in part, is because of its high antioxidant capacity. Additionally, flavonoids improve insulin resistance and sensitivity, dyslipidemia, endothelial function, and blood pressure, as well as lower oxidative stress and inflammatory processes. As a result, they may be able to stop the progression of long-term vascular consequences of diabetes, such as cardiovascular disease, neuropathy, nephropathy, and retinopathy. Therefore, the effects of nutraceuticals (as an alternative treatment) on diabetic-related micro- and macrovascular problems are the main focus of this review.

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Section: (A) Functional Foodsmentioning

confidence: 99%

Impact of Nutraceuticals on Type 1 and Type 2 Diabetes Mellitus-Induced Micro- and Macrovasculopathies

Mabena,

Fasemore,

Nkomozepi

2023

Applied Sciences

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“…However, despite the reasonable rationale provided by the above discussed association data prospective studies on the effect of VD administration on DR in humans are lacking. In fact, although treatment of DR is often associated with the administration of dietary supplements [86] only very few studies specifically supplementing VD in patients with DR have been published so far [87][88][89]. These were short term studies mainly focusing on biochemical, immunological and inflammatory markers of vascular damage in patients with 7 vs. -0.9 pg/ml; (p = 0.001)).…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects

Tecilazich

Formenti

Giustina

2020

Rev Endocr Metab Disord

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Epidemiological data predict a dramatic increase in the prevalence of diabetes and of diabetic retinopathy (DR)the most common complication of diabetes-for which however we do not have so far effective tools for prevention and treatment. Since hypovitaminosis D is very frequent in patients with diabetes and vitamin D (VD) has vascular protective properties, several studies have addressed the association of VD deficiency with DR and its severity and progression, whereas the effects of VD supplementation on its natural history are largely unknown. Here we review the available evidence that supports the possible protective role of VD in DR and suggests to determine the VD levels in DR patients calling for a definitive randomized clinical trial to ascertain whether VD supplementation could protect against DR.

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Diyabetik Retinopatili Hastalarda Serum D Vitamini Düzeyinin Değerlendirilmesi

ÖZER,

GÜÇLÜ,

BAYSAL

2024

Bozok Tıp Dergisi

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Amaç: Bu araştırmanın amacı diyabetik retinopatisi (DR) olan ve olmayan diyabetik hastaların serum D vitamini düzeylerini değerlendirmektir. Hastalar ve Yöntem: Bu kesitsel çalışmaya diyabetik retinopati geliştiren elli hasta ve diyabetik retinopatisi olmayan kırk sekiz diyabetes mellituslu hasta dahil edildi. Oftalmolojik muayeneye ile diabetes mellituslu hastalar proliferatif olmayan retinopati (NPDR) ve proliferatif retinopati (PDR) olarak kategorize edildi. Hastalara açlık kan şekeri (AKŞ), hemoglobin A1c (HbA1c), 25-hidroksi D vitamini (25-OH D), kreatinin, üre, kalsiyum, fosfor, idrarda protein testi yapıldı. D vitamini eksikliği, serum 25-OH D düzeyi < 20 ng/mL olarak tanımlandı. Bulgular: Diyabetik hastaların tümünde yetersiz D vitamini olduğu saptandı (serum 25-OH D düzeyi = 20-30 ng/mL). DR'li hastalarda ortalama serum 25-OH D konsantrasyonu, DR'si olmayanlara göre daha düşüktür (sırasıyla 23,47 ± 7,20 ng/mL ve 30,16 ± 7,00 ng/mL, p

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Concentration of NK cells after β-glucan and vitamin D supplementation in patients with diabetic retinopathy

Cited by 4 publications

References 44 publications

Impact of Nutraceuticals on Type 1 and Type 2 Diabetes Mellitus-Induced Micro- and Macrovasculopathies

Impact of Nutraceuticals on Type 1 and Type 2 Diabetes Mellitus-Induced Micro- and Macrovasculopathies

Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects

Diyabetik Retinopatili Hastalarda Serum D Vitamini Düzeyinin Değerlendirilmesi

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