Concentration of Serum Protein in Different Types of Edema

Cardiac Output, Blood and Interstitial Fluid Volumes, Total Circulating Serum Protein, and Kidney Function During Cardiac Failure and After Improvement 1

“…Of 261 cases culled from the literature and other sources, 212, or 81.2 per cent, showed a total serum protein of less than 6.6 grams per 100 cubic centimeters, with a mean total serum protein of 5.67 grams per 100 cc. The reduction is due almost exclusively to a drop in serum albumin; of 127 cases in which the protein fractions were determined (17,19,20,21,22,25), 117, or 92.6 per cent, showed a serum albumin of less than 4.6 grams with a mean serum albumin concentration of 3.41 grams per 100 cc.…”