Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity

He, Qing; Zhang, Pinggn; Zou, Li; Li, Hongxun; Wang, Xiuqin; Zhou, Shan; Fornander, Tommy; Skog, Sven

doi:10.3892/or.14.4.1013

Cited by 27 publications

(46 citation statements)

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“…1). Among these, 12 investigated solid tumors (8,12,(32)(33)(34)(35)(36)(37)(38)(39)(40)42,44) and included 1,538 patients and 1,484 controls and 3 investigated non-solid tumors (19,40,42) and included 302 patients and 180 controls. The solid tumors included 7 breast carcinomas (33,35-39,43), 2 renal Funnel plot of sensitivity and specificity of thymidine kinase.…”

Section: Resultsmentioning

confidence: 99%

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Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis

et al. 2013

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Abstract. Thymidine kinase 1 (TK1) is an enzyme involved in nucleic acid synthesis and is therefore considered to be an important tumor proliferation marker. The aim of the present study was to determine the diagnostic role of TK1 measurement in cancer. An extensive electronic search was performed in PubMed, EMBASE and the Cochrane Library using the keywords 'thymidine kinase 1' and 'tumor' and synonyms. This study was conducted as part of a project to establish evidence-based guidelines for the diagnosis and treatment of cancer. A total of 453 abstracts were screened, after which the full text of 40 studies were selected for further investigation, including screening of the references cited by studies in the original search. Fifteen studies were enrolled following full-text evaluation. The areas under the receiver operating characteristic curves for the radioenzymatic assay (REA), the chemiluminescence immunoassay (CLIA) and the total were 0.88, 0.75 and 0.8, respectively. These results were all between <0.9 and >0.7, which suggested a moderate diagnostic efficacy. The positive likelihood ratio of the CLIA method was the highest (10.229), which demonstrated that CLIA exhibited a satisfactory specificity in tumor diagnosis. However, TK1 as a single diagnostic tumor marker was not of significant value and the combination of more tumor markers in the diagnosis of tumors may be preferable.

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Section: Resultsmentioning

confidence: 99%

“…TK1 is located at chromosome 17q25, is exclusively expressed in the cytoplasm of dividing cells and is absent in resting cells (4)(5)(6)(7). TK1 activity increases during the G1̸S phase and decreases through the G2̸mitosis phase (8)(9)(10). TK1 activity is essential for the balance of the intracellular TTP levels.…”

Section: Introductionmentioning

confidence: 99%

Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis

et al. 2013

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“…In proliferating normal and tumor cells, the level of TK1 starts to increases at late G 1 phase, and reaches a maximum in late S-phase/early G 2 phase of the cell cycle, but in quiescent cells, TK1 is almost completely absent. This singles out TK1 as a useful indicator of cellular proliferation, and hence for malignancy (3)(4)(5)(6). Serum TK1 protein (STK1p) level, determined by non-invasive serological methods, was found to be an emerging potential cell proliferation biomarker for the prognosis of cancer patients (7)(8)(9), for monitoring tumor treatments, relapse, follow-up and survival, and particularly for the early detection of cancer development risk (10,11).…”

Section: Introductionmentioning

confidence: 99%

Serum thymidine kinase 1 is a reliable maker for the assessment of the risk of developing malignancy: A case report

et al. 2015

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Abstract.With regard to different types of malignancies, thymidine kinase 1 (TK1) is a useful prognostic marker in clinical oncology, both as a serum proliferation marker and in immunohistochemistry. The present study investigated the use of serum TK1 protein (STK1p) for the identification of multiple proliferating diseases linked to the risk of developing cancer, by following one patient during the period of [2003][2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014]. The patient presented with adenomatous polyps in the stomach in 2003, follicular cervicitis in 2007 and hyperplasia of the breast/fibrocystic breasts in 2010. The breast cysts increased from 4x5 mm in size in 2010 to 8x7 mm in size in 2013, and were assessed as a suspicious malignancy at the end of this period. In parallel, the STK1p values increased from 2.0 to 7.6 pM. Based on this information, a minimally invasive surgery using the Mammotome ® Biopsy System was performed. Immunohistochemistry on the cyst tissue showed strong staining of TK1 in the ductal epithelial cells and thus confirmed the abnormal proliferation in the lesion. One week after the surgery, the STK1p value had decreased to almost normal values (1.6 pM), but then fluctuated above 2.0 pM for the next 7 months. After the surgery, the patient was re-examined and small foci with squamous cell hyperplasia and a suspected ulcerated cervix, as well as flat gastric erosive, were identified, but not treated; this may explain why the STK1 P-values did not return to within normal values. The patient is currently being followed up using STK1p analysis combined with imaging/pathology in order to begin therapeutic intervention as early as possible to avoid the risk of developing cancer. Overall, STK1p is useful in health screening to identify individuals at risk of developing premalignancy/malignancy.

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“…Serum TK activity is sometimes elevated in subjects with nonhematopoietic neoplasms (such as breast carcinoma, epithelial ovarian cancer, and lung cancer), 5,8,12 infections with some viruses (Measles virus, Rubella virus, Varicella virus, Human herpesvirus 1, and genus Cytomegalovirus), and in pregnant women. 7 In the current study, postmortem examination did not reveal neoplastic disease in the 7 cows with elevated TK activity, and the causes of increased activity are as yet unknown.…”

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confidence: 99%

Serum Thymidine Kinase Activity as a Useful Marker for Bovine Leukosis

Sakamoto

Ohbayashi²,

Matsumoto

et al. 2009

J VET Diagn Invest

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Abstract. Serum thymidine kinase (TK) activity has recently been evaluated as a serum marker for human and canine hematopoietic neoplasms. The purpose of the current study was to establish the significance of serum TK activity in the diagnosis of bovine leukosis. The discrimination value for TK activity was set at 5.4 U/l based on the receiver operating characteristic curve. In the group of clinically healthy cows, only 2 out of 83 cows (2.4%) had serum TK activity above the discrimination value. In contrast, 19 out of 20 cows (95.0%) with bovine leukosis showed serum TK activity above the discrimination value, although only 7 of 79 (8.9%) cows diagnosed with diseases other than bovine leukosis showed elevated serum TK activity. Thymidine kinase activities of all Bovine leukemia virus-positive cows with or without lymphocytosis were below the discrimination value. Sensitivity and specificity of measuring serum TK activity as a diagnostic tool for bovine leukosis was 95.0% and 95.9%, respectively. Results indicate that serum TK activity may be a marker for bovine leukosis.

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Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity

Cited by 27 publications

References 0 publications

Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis

Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis

Serum thymidine kinase 1 is a reliable maker for the assessment of the risk of developing malignancy: A case report

Serum Thymidine Kinase Activity as a Useful Marker for Bovine Leukosis

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