Concentration, Source, and Potential Human Health Risk of Heavy Metals in the Commonly Consumed Medicinal Plants

Kohzadi, Shadi; Shahmoradi, Behzad; Ghaderi, Ebrahim; Loqmani, Hozan; Maleki, Afshin

doi:10.1007/s12011-018-1357-3

Cited by 112 publications

(50 citation statements)

References 25 publications

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“…Consumption of contaminated food can cause more than 200 risks of acute and chronic diseases, from digestive infections to cancer [95]. Numerous studies have shown that heavy metals exert dangerous effects on human health, causing cancer, damage to the nervous system, blood composition [96][97][98].…”

Section: Potential Risks For Human Healthmentioning

confidence: 99%

“…The interest in the effects of heavy metals on medicinal plants has increased in recent decades, articulating the acute need to monitor and analyze the condition of medicinal plants affected by the presence of heavy metals, in order to avoid health hazards. The risks to human health associated with the presence of heavy metals in medicinal plants have led to the establishment of safety standards for herbal remedies that provide for maximum permitted concentrations for some heavy metals in natural remedies [96].…”

Section: Potential Risks For Human Healthmentioning

confidence: 99%

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Heavy Metal Contamination of Medicinal Plants and Potential Implications on Human Health

Asiminicesei¹,

Vasilachi²

2020

Rev. Chim.

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This survey focuses on the problem of medicinal plants contamination due to environmental pollution produced by many different industrial activities and atmospheric deposition of some toxic compounds. This analysis is important since plants can easily absorb organic and inorganic compounds from all environmental compartments (water, soil, air), which can enter and be transferred in the trophic chain, up to humans. Medicinal plants are relevant for study in relation with their interactions with different contaminants, in particular those inorganic persistent as heavy metals, because they are used in entire world for their beneficial properties, and represent a significant part of traditional medicine. According to World Health Organization (WHO), 65-80% of world`s population depends on herbal products as the primary form of health care. Frequent use of medicinal plants to improve health, in the context of current pollution, requires special attention, since they can contain heavy metals in their structures, which can generate hazards and risks on human health throughout the subsequent consumption of contaminated medicinal plants as teas, other drinks, cosmetics.

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Section: Potential Risks For Human Healthmentioning

confidence: 99%

Section: Potential Risks For Human Healthmentioning

confidence: 99%

Heavy Metal Contamination of Medicinal Plants and Potential Implications on Human Health

Asiminicesei¹,

Vasilachi²

2020

Rev. Chim.

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“…Выводы о зависимости содержания кадмия в ЛРС от места сбора образцов хорошо согласуются с данными литературы, согласно которым содержание кадмия, превышающее норму, зафиксировано в некоторых образцах ЛРП и ЛРС из ближневосточного региона [31][32][33], а также из регионов, отягощенных антропогенным влиянием [4,34,35].…”

Section: Fig 2 Content Of Cadmium In the Herbal Medicinal Products unclassified

“…Так, в [10] отмечено, что ни в одном из исследованных образцов растений содержание ртути не превышает 0,2 мг/кг. Схожие данные приведены в работах [36][37][38][39].…”

Section: Fig 2 Content Of Cadmium In the Herbal Medicinal Products unclassified

Comparative Analysis of Heavy Metal and Arsenic Content in Various Herbal Dosage Forms Marketed in Russia

Щукин¹,

Кузьмина²,

Shvetsova³

et al. 2020

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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The inclusion of requirements for independent determination of arsenic, cadmium, mercury, and lead, and the current sample preparation techniques into the State Pharmacopoeia of the Russian Federation (Ph. Rus.) requires the revision of the existing limits for elemental toxicants in herbal substances and herbal medicinal products produced from them.The aim of the study was to analyse the data on elemental toxicant content obtained during quality control of herbal substances (herbs, medicinal herb mixtures, extracts, and tinctures) using current test methods and sample preparation techniques, and to compare the obtained results with the Russian and foreign scientific and specialist literature.Materials and methods: the internal data on the content of critical heavy metals and arsenic in different dosage forms of herbal medicinal products, which were obtained by inductively coupled plasma mass spectrometry after sample preparation by decomposition in closed vessels, were compared with literature data. Results: it was demonstrated that the content of lead, cadmium, and mercury in all the test samples did not exceed the Ph. Rus. limits and was consistent with the analysed literature. The arsenic content in some herbal medicinal products was higher than the established Ph. Rus. limits, but complied with the less stringent Ph. Eur. and USP requirements for herbal substances. The authors investigated the link between the content of elemental toxicants and the place of collection and the part of the plant being tested. It was shown that different types of medicinal plants had a tendency to accumulate particular elements. The authors determined the content of the elements to be controlled in extracts and tinctures. The differences in the Russian and foreign requirements for the content of elemental toxicants may be attributed to the method of obtaining experimental data that form the basis for the setting of limits.Conclusions: the results of the study confirm the validity of the existing limits for elemental toxicants in herbal medicinal products. The authors demonstrated the need to revise the existing limits for arsenic in herbal medicinal products.

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“…Pollution of the environment with heavy metals causes these metals to penetrate plants growing on contaminated soils [19,20]. The European Pharmacopeia sets limits for some popular heavy metals, including cadmium, lead, mercury, arsenic, cobalt, nickel, vanadium and thallium, which can be found in plant materials [21,22]. No additional regulations need to be set for other heavy metals that can be detected in medicinal plants, including, aluminium, iron, copper and zinc [22].…”

Section: State-of-the-art Knowledgementioning

confidence: 99%

Prospects for the use of herbal medicines in relation to progressing environmental pollution

Łuszczki¹,

Gustaw-Rothenberg²,

Chmielewski³

et al. 2020

Med Środow.

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Due to the increasing pollution of the natural environment, the amount of impurities that can accumulate in herbs and plants used for therapeutic purposes as medicinal plants also increases. As many plant materials have medicinal properties and have been used as medicinal remedies,they must be subjected to rigorous assessments according to material quality standards.Presently, however, there is no guarantee that there has been no change in the amount and content of medicinal bioactive substances, compared to plants used years ago in traditional folk medicine. At present, there are great prospects in the use of medical plants, especially if the medicinal plants are free from pollution originating from the contaminated natural environment. The attention of researchers should focus not only on seeking new bioactive compounds and finding new drugs in plants, but also on ensuring high standards of quality regarding the evaluation of the chemical purity of plants growing in the environment exposed to contamination and pollution. The combination of both challenges can help patients suffering from increasing numbers of ailments and diseases of civilization. Researchers must also be actively involved in the process of detection any harmful substances penetrating from the environment into plants by applying various biomedical and chemical techniques to detect some novel, as yet unknown threats, in order not to expose patients to them.

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Concentration, Source, and Potential Human Health Risk of Heavy Metals in the Commonly Consumed Medicinal Plants

Cited by 112 publications

References 25 publications

Heavy Metal Contamination of Medicinal Plants and Potential Implications on Human Health

Heavy Metal Contamination of Medicinal Plants and Potential Implications on Human Health

Comparative Analysis of Heavy Metal and Arsenic Content in Various Herbal Dosage Forms Marketed in Russia

Prospects for the use of herbal medicines in relation to progressing environmental pollution

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