Concentration-Time Course in the Plasma of Man of Radiomercury Introduced as a Mercurial Diuretic 1

In previous studies (1) some aspects of the mechanisms of renal excretion of radiomercury 8 labeling an organic mercurial diuretic (Mercuhydrin 4) were observed in acute experiments in which renal venous blood and pelvic urine were obtained by means of catheters in a few subjects. The present observations are concerned with the rate of urinary excretion of the radiomercury of this diuretic in a larger number of subjects over a longer period of time. The percentage of injected radiomercury which was excreted in the urine, the time relationships of the diuretic effects and the urinary excretion of the mercury, the biologic decay rates of the isotopes, as well as other physiologic phenomena were determined from these experiments. Because of the extensive use of mercurial diuretics in clinical medicine and the problems of toxicity, the biologic decay rates are of importance. MATERIALS AND METHODSEighty-three hospitalized subjects were studied. The diuretic was administered intravenously and intramuscularly to normal human subjects and to subjects with congestive heart failure. Table I shows the route of ad-

Section: Methodsmentioning

confidence: 99%

The Urinary Excretion and Biologic Decay Periods of Radiomercury Labeling a Mercurial Diuretic in Normal and Diseased Man 1

Burch¹,

Ray²,

Threefoot³

et al. 1950

“…These differences in arteriovenous concentration observed for the kidneys, liver and upper extremity contribute to a better understanding of the mechanisms responsible for the concentration-time course in the blood of the tracers previously reported for man (2). For example, Figure 11 illustrates the concentration-time course of radiomercury in the serum of femoral arterial blood of Subject No.…”

Section: Urinementioning

confidence: 65%

Considerations of Renal, Hepatic, and Extremital Arteriovenous Differences in Concentration of Radiomercury of a Mercurial Diuretic 1

Milnor¹,

Burch²,

Ray³

et al. 1950

Mercurial diuretics are employed extensively today in the management of congestive heart failure, but the mechanism by which elimination of electrolytes and water is increased is not thoroughly understood. Furthermore, the metabolism and pharmacodynamics of mercury are only partially known despite the numerous investigations into the diuretic action of mercury. The majority of these studies have been concerned principally with clinical observations on the comparative value of various mercurial preparations, time of onset and quantity of diuresis, efficacy of the preparation in the management of edematous states and toxicity. The anatomic changes in the kidney appearing as a reaction to mercury have been adequately studied, but the physiologic renal changes are not so well understood. drin 8) labeled with radioactive mercury 4has been under study in this laboratory. Observations have been made of the simultaneous concentration-time course of the radiomercury in the serum of the blood from a femoral artery, right renal vein, hepatic vein and an extremital vein and in the urine collected directly from the renal pelvis and urinary bladder. It is the purpose of this presentation to report certain aspects of these data. MATERIALS AND METHODSThese studies were conducted on seven subjects from the Charity Hospital; in five, right renal venous catheterization was performed and in two, hepatic venous catheterization (Tables I and II). No subject had received a mercurial diuretic within five days prior to the study. All studies were made at least ten hours postprandially, but no effort was made to regulate diet or intake of water.In three subjects the urine was collected with ureteral catheters,5 by bilateral catheterization in Subject Nos. 1 and 3 and by unilateral catheterization in Subject No. 2; in the other four vesical catheterization was employed. Catheterization of the right renal vein or of a hepatic vein according to the technic of Cournand and Ranges (1) was performed under fluoroscopic control. The position of the catheter was substantiated fluoroscopically at the termination of the study and in three subjects by measuring renal extraction of para-aminohippurate as well. Five per cent dextrose in distilled water was the infusing fluid through the catheter, the quantity admin3The sodium salt of methoxyoximercuripropylsuccinylurea with theophylline, prepared with radiomercury in this laboratory by

“…Mercuhydring (6,7) and Neohydring (8,9) have been shown to disappear rapidly from the blood stream following intravenous administration and to accumulate in the renal cortex in high concentration. Both drugs are highly bound to plasma proteins, hence are sparingly filtered through the glomerular capillaries, yet both are rapidly eliminated in the urine.…”

Section: X-hg-c-c-c(-r Hoy Hmentioning

confidence: 99%

Studies on Structure Diuretic Activity Relationships of Organic Compounds of Mercury 1

Kessler¹,

Lozano²,

Pitts³

1957

The mercurial diuretics in commiiiion use today exhibit certain basic similarities in structure. All are mercurated derivatives of substituted three carbon compounds of the type indicated below, in which the three substituents are designated X, OY, and R.H H H X-Hg-C-C-C(-R HOY H According to Friedman ( 1 ), the nature of the X substituent (usually halogen, theophylline or thioglycolate) has no effect on diuretic potency if the compound is given intravenously, but does influence both hyperacute (cardiac and respiratory arrest) and acute (7 to 14-day) renal toxicity.