Concentrations of Alpha-Fetoprotein, Insulin-Like Growth Factor Binding Protein-3, c-erbB-2, and Epidermal Growth Factor in Serum of Patients With Endometriosis

Philippoussis, Fabianne; Gagné, Danièle; Hugo, Patrice; Gosselin, Diane

doi:10.1016/j.jsgi.2003.10.005

Cited by 14 publications

(13 citation statements)

References 42 publications

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“…IL1 and IL6) that induce the synthesis of CRP have suppressive effects on the synthesis of albumin and AFP, it could be hypothesized in this study that insignificant change in the level of AFP observed in this study may be associated with increased level of CRP observed in the leiomyoma patients. This study seems to agree with the report by Philippoussis et al (2004) that patients with endometriosis did not show significant change in the serum level of AFP.…”

Section: Discussionsupporting

confidence: 93%

Assessment of Tumor markers, C-reactive Protein, Cortisol and Total Plasma Peroxides Levels in Uterine Leiomyoma Patients

Akiibinu

Amballi

Jagun

et al. 2017

ESJ

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Objective: The pathophysiology of uterine leiomyoma is yet to be fully understood. This study determined the status of cortisol, C-reactive protein, total plasma peroxide and selected tumor markers in uterine leiomyoma patients. Materials and Methods: Forty-eight individuals (aged 25-45 years) with uterine leiomyoma (nodules=1-4; size=5-120mm) were recruited for this study. Forty apparently age-matched normal individuals without uterine European Scientific Journal March 2017 edition vol.13, No.9 ISSN: 1857 -7881 (Print) e -ISSN 1857 334 leiomyoma served as controls. The patients and controls were selected after confirmation of the status of uterine leiomyoma by ultrasound imaging technique. The plasma levels of total plasma peroxides(TPP), cortisol, carcino-embryonic antigen(CEA), alpha fetoprotein (AFP), carbohydrate antigen 125(CA125) and C-reactive protein(CRP) were determined in them using spectrophotometry, enzyme linked immunosorbent assay and single radial immunodiffusion (Maccini) methods respectively. Results: The result shows significantly higher levels of TPP (p<0.001), CRP (p<0.001) and CA125 (p<0.002) in uterine leiomyoma patients when compared with the controls. There were no significant (p>0.05) changes in the plasma levels of cortisol, CEA and AFP in the leiomyoma patients when compared with the controls. Significant (r=0.521, p=0.03) correlation existed between the number of myoma nodules and the levels of CRP in the leiomyoma patients. The size of the nodules correlated significantly (r=0.47, p=0.04) with the plasma levels of TPP. Conclusion: Elevated levels of CRP and TPP could indicate oxidative stress and inflammatory response in uterine leiomyoma patients. The induced inflammation and oxidative stress may increase with increase in number and size of the myoma nodules respectively. Higher level of CA125 could be a feature of uterine leiomyoma.

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Section: Discussionsupporting

confidence: 93%

Assessment of Tumor markers, C-reactive Protein, Cortisol and Total Plasma Peroxides Levels in Uterine Leiomyoma Patients

Akiibinu

Amballi

Jagun

et al. 2017

ESJ

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“…EGF is a single polypeptide chain of 53 amino acid residues and plays a role in many processes such as DNA synthesis, mitogenesis, and proliferation of many cell types, including endometrial cells (44). Previous studies have found no difference in levels of EGF receptor between women with and without endometriosis (16), and serum levels of EGF itself were not found to correlate with the disease (45). Results obtained from our research are in accordance, with similar serum levels of EGF between patients with endometriosis and controls.…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor Serum Levels in Women with Advanced Endometriosis

et al. 2016

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Context. Endometriosis is a common gynecological disease, characterized by ectopic deposits of endometrial tissue outside of the uterine cavity, and it is associated with pelvic pain and infertility, with an important impact on the quality of life. At this point there is a controversy regarding the etiology and pathophysiology of endometriosis and it seems that pro-angiogenic growth factors might be involved, but their role is not completely understood. Objective. To evaluate the serum concentration of the main growth factors in patients with diagnosed endometriosis compared to healthy controls. Subjects and methods. A total of 157 women were divided into two study groups (Group I-endometriosis; Group 2-healthy women). Serum levels of VEGF, G-CSF, GM-CSF, b-FGF, EGF, and HGF were measured with Human Multiplex Cytokine Panels. Results. VEGF serum levels were significantly lower in women with endometriosis compared to controls (1.924±0.145 compared to 1.806±0.078 pg/mL, p<0.001). Serum levels of GM-CSF, b-FGF, EGF, and HGF respectively did not differ significantly between patients with endometriosis and healthy controls. G-CSF had a very low detection rate. Conclusions. The present study showed that VEGF serum levels are significantly lower in endometriosis patients compared to healthy controls, indicating a possible role in endometriosis pathogenesis.

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“…IGF-1 levels in eutopic endometrium are lower in severe endometriosis (185), whereas ectopic endometrium and peritoneal fluids show higher levels (186,187). There was no association found, however, between serum levels of IGFBP-3, alpha-fetoprotein (AFP) and EGF and the existence of endometriosis (188).…”

Section: Angiogenic-and Growth Factorsmentioning

confidence: 93%

Endometriosis: harmful survival of an ectopic tissue

Garai

Molnár

Varga³

et al. 2006

Front Biosci

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Endometriosis results from implantation of endometrial tissue outside the uterine cavity. Endometriosis might remain asymptomatic and discovered accidentally. However, it may cause symptoms, which include chronic pelvic pain, bleeding, infertility, and increases susceptibility to development of adenocarcinoma. The most prevailing hypothesis is that endometriosis results from implantation of endometrial tissue that gains access to peritoneal cavity by retrograde flow during menstruation. The factors contributing to the establishment and persistence of the endometriotic lesions (plaques) most probably include abnormalities of the genital tract, genetic predisposition, hormonal imbalance, altered immune surveillance, inflammatory response and abnormal regulation of the endometrial cells. The mediators that contribute to survival and progression of endometriosis are likely involved in the development of the symptoms of this process. Genomic studies have started to delineate the wide array of mediators involved and the complex genetic background required in the development of endometriosis. This review summarizes our current knowledge regarding the pathogenesis of endometriosis, including progress made with transgenic animals, and a clinical perspective on the diagnosis and management of this common process.

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Concentrations of Alpha-Fetoprotein, Insulin-Like Growth Factor Binding Protein-3, c-erbB-2, and Epidermal Growth Factor in Serum of Patients With Endometriosis

Abstract: Although AFP, IGFBP-3, c-erbB-2, and EGF are not altered in the circulation of patients with endometriosis, their involvement in the development of endometriotic lesions cannot be excluded.

Cited by 14 publications

References 42 publications

Assessment of Tumor markers, C-reactive Protein, Cortisol and Total Plasma Peroxides Levels in Uterine Leiomyoma Patients

Assessment of Tumor markers, C-reactive Protein, Cortisol and Total Plasma Peroxides Levels in Uterine Leiomyoma Patients

Vascular Endothelial Growth Factor Serum Levels in Women with Advanced Endometriosis

Endometriosis: harmful survival of an ectopic tissue

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