Concentrations of cadmium, lead, selenium, and zinc in human blood and seminal plasma

Xu, Bo; Chia, Sin-Eng; Ong, Choon‐Nam

doi:10.1007/bf02916820

Cited by 43 publications

(20 citation statements)

References 29 publications

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“…When blood is added to BSK-II medium, RpoS-activated genes are induced (82). The high concentration of Zn 2ϩ relative to low concentration of Mn 2ϩ in human blood (which contains about 100 M Zn 2ϩ [90][91][92]) may account for this observation. Increased CO 2 has been shown to enhance BosR, RpoS, and OspC levels (83 lated by CO 2 , which further increases the level of BosR.…”

Section: Discussionmentioning

confidence: 99%

“…7). Given that human blood contains a high concentration of Zn 2ϩ relative to a low concentration of Mn 2ϩ (90)(91)(92), it is likely that the tick midgut during the feeding is under low Mn 2ϩ and high Zn 2ϩ conditions that favor the production of BosR and activation of the RpoS pathway. This model cannot explain the situation in the feeding larvae when spirochetes migrate from mammals to larval midguts, in which the RpoS pathway is not activated even in the presence of mammalian blood.…”

Section: Discussionmentioning

confidence: 99%

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Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi

Troxell

Yang

et al. 2013

Infect Immun

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi

Troxell

Yang

et al. 2013

Infect Immun

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“…This was also shown by the research on blood cadmium level in a group of men in Singapore, where the mean cadmium level found was 1.31 mg/l (Xu et al, 1994). In Japan, a research conducted by Watanabe and associates showed that the mean cadmium level in blood of nonexposed women was 1.84 mg/l (Watanabe et al, 1996).…”

Section: Cadmium Levelsmentioning

confidence: 65%

Exposure assessment of male recruits in Slovenia to cadmium and lead due to biological monitoring

Eržen¹,

Kragelj

2004

J Expo Sci Environ Epidemiol

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Aims: In Slovenia, there were no data available for an assessment of cadmium and lead levels in the population till 2001. The present study was conducted to evaluate the cadmium and lead burden from all sources (air, food, water) with the aim of obtaining initial information on cadmium and lead levels in blood of healthy and occupationally unexposed young males. Methods: There were 464 participants included in the analysis of blood cadmium and lead levels, aged between 18 and 27 years, the median age being 20 years. Blood samples of maximum 2 ml were taken from the cubital vein for analysis of cadmium and lead levels. Results: There were 463 blood samples analyzed for cadmium and 464 for lead. Of all tested persons, 38.2% had less than 0.5 mg/l of cadmium in their blood and 28.2% up to 1 mg/l. The median level of blood cadmium was 0.5 mg/l. The percentage of recruits with blood lead level over 100 mg was 3.1%. The median level of blood lead was 35 mg/l. The differences in blood levels of both pollutants were statistically significant with regard to the region of permanent residence (Po0.001). Conclusions: The results of the study give a good assessment of cadmium and lead burdening of young Slovene male population. The information obtained provides a foundation for further comparative research at the international level as well as for further study and risk assessment of individual population groups exposed to greater risk due to their lifestyle and eating habits.

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“…33 Higher levels of Cd in WB compared to SP was associated with a significant decrease in sperm count, especially at a level higher than 1.5 μg/L. 34 In addition, a relation has been shown between lower levels of Cd in SP and low semen volume and sperm motility. 13 High levels of SP Cd was found to be associated with abnormal sperm parameters.…”

Section: Discussionmentioning

confidence: 98%

The Effect of Blood and Seminal Plasma Heavy Metal and Trace Element Levels on Sperm Quality

Kahraman¹,

Hassa²,

Karataş³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Infertility is shown in approximately 10-15% of the couples. Male infertility is responsible for at least 50% of them. In these infertile couples, male is responsible alone in 30% while male and female are responsible together in 20%. The semen analysis is the first laboratory test which should be done to evaluate the male infertility. Heavy metals and trace elements affect sperm production, motility and morphology. The aim of this study is to determine zinc, copper, lead and cadmium levels in blood and seminal samples of men and to evaluate their relationship with sperm quality parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty-two men with abnormal sperm quality parameters and 10 control subjects were included in the study. Zinc, copper, cadmium and lead levels were measured in blood and semen. The results were compared. R Re es su ul lt ts s: : Lead levels in blood, cadmium levels both in blood and seminal plasma were significantly higher in men with abnormal sperm analyses (p<0.05). There was a positive correlation between seminal plasma zinc level and sperm count, motility and morphology (p<0.001) and between seminal plasma copper level and sperm count and morphology (p<0.05). There was a negative correlation between lead level and sperm count, motility and morphology (p<0.001). Likewise, there was a negative correlation between blood cadmium level and sperm motility and morphology (p<0.05) and between seminal plasma cadmium level and sperm motility (p<0.05). C Co on nc cl lu us si io on n: : Zinc and copper affect sperm quality positively whereas lead and cadmium shows a negative effect. Exposure to heavy metals is an important etiology in the male infertility problem and should be treated seriously.K Ke ey y W Wo or rd ds s: : Smoking; metals, heavy; trace elements; infertility, male Ö ÖZ ZE ET T A Am ma aç ç: : İnfertilite, çiftlerin %10-15'inde görülmektedir. En az %50'sinde erkek infertilitesi sorumludur. Bu infertil çiftlerin %30'unda tek başına erkek, %20'sinde de kadın faktörü ile beraber sorumludur. Erkek infertilitesini değerlendirmek için ilk yapılması gereken test semen analizidir. Ağır metaller ve eser elementler sperm üretimini, motilitesini ve morfolojisini etkilemektedir. Bu çalışma erkeklerin kan ve seminal örneklerinde çinko, bakır, kurşun ve kadmiyum düzeylerini saptamak ve sperm parametreleri ile ilişkilerini araştırmak için yapıldı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya anormal sperm parametreli kırk iki ve kontrol grubu olarak 10 kişi dahil edildi. Kanda ve semende çinko, bakır, kadmiyum ve kurşun düzeyleri ölçüldü. Anormal sperm parametreli erkeklerin sonuçları normal sperm parametreleri ile karşılaştırıldı. B Bu ul lg gu ul la ar r: : Sperm analizi anormal olan erkeklerde kurşun seviyesi kanda, kadmiyum seviyesi hem kanda hem de seminal plazmada anlamlı olarak yüksekti (p<0,05). Seminal plazma çinko seviyesi ile sperm sayısı, motilitesi ve morfolojisi arasında (p<0,001) ve sem...

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Concentrations of cadmium, lead, selenium, and zinc in human blood and seminal plasma

Cited by 43 publications

References 29 publications

Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi

Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi

Exposure assessment of male recruits in Slovenia to cadmium and lead due to biological monitoring

The Effect of Blood and Seminal Plasma Heavy Metal and Trace Element Levels on Sperm Quality

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