Concentrations of Ceftibuten in Bronchial Secretions

Scaglione, F; Triscari, F; Demartini, G.; Arcidiacono, M.M.; Cocuzza, Clementina; Fraschini, F.

doi:10.1159/000239349

Cited by 3 publications

References 10 publications

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Ceftibuten: An Overview

Owens,

Nightingale,

Nicolau

1997

Pharmacotherapy

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Ceftibuten is an orally active third‐generation cephalosporin that exhibits good microbiologic activity against many gram‐negative and select gram‐positive organisms. It is stable against plasmid‐mediated β‐lactamases, including extended‐spectrum β‐lactamases. Ceftibuten has been shown to be effective in the treatment of upper and lower respiratory tract infections and, although not approved indications, complicated and uncomplicated urinary tract infections in both adults and children. It is readily absorbed (75–90%) after oral administration, with peak serum levels of 17 μg/ml in healthy volunteers. Its half‐life is 2.5 hours in healthy volunteers and is increased in elderly patients to approximately 3.2 hours. Elimination occurs primarily through the kidneys, requiring dosage adjustments to be made when creatinine clearance falls below 50 ml/minute. The drug's safety profile is favorable and similar to that of most other cephalosporins. Based on pharmacokinetic information and clinical trial data, ceftibuten can be dosed once/day for most infections. It is an alternative to other currently available antimicrobial agents in the treatment of indicated upper and lower respiratory tract infections.

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Ceftibuten: An Overview

Owens,

Nightingale,

Nicolau

1997

Pharmacotherapy

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β-Lactam antibiotics

Noel¹,

Kendler²,

Hartman³

et al. 2010

Infectious Diseases

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Ceftibuten: A New Expanded-Spectrum Oral Cephalosporin

Guay

1997

Ann Pharmacother

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Objective To review the antimicrobial activity, pharmacokinetics, clinical efficacy, and tolerability of ceftibuten, a new expanded-spectrum oral cephalosporin. Data Sources Literature was identified by a MEDLINE search (January 1983–June 1996) of the medical literature, review of English-language literature and bibliographies of these articles, and data on file. Study Selection Clinical efficacy data were selected from all published and unpublished trials and abstracts that mentioned ceftibuten. Additional information concerning in vitro susceptibility, safety, chemistry, and pharmacokinetic profile of ceftibuten also was reviewed. Data Synthesis Ceftibuten, an oral expanded-spectrum cephalosporin, has a broad spectrum of activity against many gram-negative and selected gram-positive organisms, including Streptococcus pneumoniae, Streptococcus pyogenes, Moraxella catarrhalis, and Haemophilus influenzae. Ceftibuten is stable to hydrolysis by many common p-lactamases. Ceftibuten is rapidly and almost completely absorbed from the gastrointestinal tract and is primarily eliminated renally as unchanged drug. The elimination half-life of ceftibuten is slightly longer than 2 hours. Efficacy has been demonstrated in a number of clinical trials in adults and children with upper and lower respiratory tract infections (e.g., acute otitis media, pharyngitis, sinusitis, bronchitis) and urinary tract infections. The adverse effect profile is equal to that of comparator agents. Conclusions Ceftibuten is an alternative to other antimicrobial agents with convenient once-daily dosing in the treatment of upper and lower respiratory tract infections. Similar to other oral expanded-spectrum cephalosporins, ceftibuten has antimicrobial activity against common pathogens of the respiratory tract and is stable in the presence of many β-lactamases. The clinical choice of an oral expanded-spectrum cephalosporin will be based on patient acceptance, frequency of administration, and cost.

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Concentrations of Ceftibuten in Bronchial Secretions

Cited by 3 publications

References 10 publications

Ceftibuten: An Overview

Ceftibuten: An Overview

β-Lactam antibiotics

Ceftibuten: A New Expanded-Spectrum Oral Cephalosporin

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