Concentrations of SP1 and ß-hCG in serum and cerebrospinal fluid and concentrations of hCG in urine in patients with trophoblastic tumour

Soma, Hiroaki; Kikuchi, K.; Takayama, M.; Saegusa, Hironao; Saito, Toshiki; Kashiwagi, Hirokazu; Sayama, Shoko

doi:10.1007/bf02199681

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…However, in this study, serum PP5 concentrations in 50% of the patients with hydatidiform mole were lower than the normal range. This indicates the measurement of SP1 is a more valuable parameter for hydatidiform mole management than PP5 [Soma et al, 1981]. The role of PP5 in trophoblastic tumor requires much more study.…”

Section: Weeks Of Gestationmentioning

confidence: 99%

Circulating Levels of Placental Protein 5 in Normal and Abnormal Pregnancies

Takayama¹,

Soma²,

Saito³

et al. 1983

Gynecol Obstet Invest

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Serum concentrations of PP5 were measured by radioimmunoassay in 219 women with normal pregnancies and 163 women whose pregnancies were complicated. PP5 in serum disappeared rapidly after delivery, with a half-life of 5–10 min in the first 10min. Serum PP5 levels were higher in uterine than in antecubital venous blood. In normal pregnancies, PP5 was detectable at 7–8 weeks of gestation; its mean concentration rose gradually to a maximum of 17.8 ± 10.2 ng/ml at 34–35 weeks of gestation. Elevated serum PP5 concentrations were noted in patients whose pregnancies were complicated by toxemia of pregnancy with appropriate-for-date baby or by twin pregnancy. Low serum PP5 concentrations tended to be found in patients whose pregnancies were complicated by abortion, intrauterine fetal death, and hydatidiform mole. Marked abnormal PP5 levels were not found in patients with maternal diabetes and placenta previa. These findings suggest that the assay of serum PP5 concentrations can be a useful parameter in determining the prognosis of abnormal pregnancies.

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Section: Weeks Of Gestationmentioning

confidence: 99%

Circulating Levels of Placental Protein 5 in Normal and Abnormal Pregnancies

Takayama¹,

Soma²,

Saito³

et al. 1983

Gynecol Obstet Invest

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“…Two months after the beginning of successful chemotherapy the temporary elevation of isolated SP-1 concentration should be interpreted as a consequence of oncolysis and not an early sign of recurrence of the tumor. In case of recur rence, SP-1 level shows stagnation in the pathological range or a steady elevation, accompanied by high P-hCG concentration [12,11]. The elevation of SP-1 during and after some months of chemotherapy of metastatic trophoblastic tumor and its absence in cases of smaller volume tumors may indicate that this phenomenon can only be observed in cases with larger volume tumors.…”

Section: Discussionmentioning

confidence: 93%

Elevated Sera Levels of SP-1 Induced by Chemotherapy in Patients with Metastatic Gestational Trophoblastic Diseases

Gn²,

et al. 1990

Oncology

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6 patients with invasive mole and 5 patients with choriocarcinoma were treated from 1983 till 1986. Serum samples were analyzed by simultaneous determining of pregnancy-specific beta-1-glycoprotein (SP-1) using enzyme-linked immunosorbent assay (ELISA) and beta subunit of human chorionic gonadotropin (p-hCG) using Serono radioimmunoassay kit. In 2 patients with metastatic gestational trophoblastic disease (MGTD) SP-1 peaks were found during chemotherapy. In patients with MGTD with normalized (3-hCG levels a repeated, temporary elevation of isolated SP-1 levels was observed within some months following chemotherapy. After the last isolated peak of SP-1 the pulmonary metastases disappeared. This phenomenon was interpreted as a consequence of the oncolytic process in the affected tissue. In 1 patient with nonmetastatic choriocarcinoma SP-1 ELISA pseudoreaction was found. To recognize these pseudoreactions, a control plate with nonimmunized rabbit IgG was used, simultaneously with SP-1 determinations.

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“…In some cases, differential levels of hCG in clinical samples can pinpoint the site of metastases (e.g. a serum-CSF ratio of greater than 60:1 is indicative of spread to the brain) (Soma et al, 1981;Bagshawe, 1984;Hammond et al, 1984).…”

Section: Gestational Trophoblastic Diseasementioning

confidence: 99%