Concentrations of sRAGE in serum and follicular fluid in assisted reproductive cycles—a pilot study

Malíčková, Karin; Jarosová, R; Kalousová, Marta; Janatková, I; Řežábek, K

doi:10.1016/j.jri.2009.06.196

Cited by 12 publications

(18 citation statements)

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“…However, there are many reports which do not support this. A study by Malickova et al [34] showed that women with significantly higher sRAGE were more likely to conceive. Rzepka et al [10] observed a negative trend for sRAGE and CRP plasma levels in a group with preterm premature rupture of membranes, and they concluded that high sRAGE concentration can be a favorable prognostic factor in the presence of symptoms of threatened premature labor.…”

Section: Discussionmentioning

confidence: 99%

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

Asan

Hao

Yang

et al. 2016

J Assist Reprod Genet

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Purpose To explore the relationships between the soluble receptor for advanced glycation endproducts (sRAGE) and the outcome parameters following in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) and investigate the protective effect of sRAGE in PCOS development regarding inflammation. Methods We conducted a prospective analysis of a subsample of 74 participants from the Reproductive Medical Center of the First Affiliated Hospital of Zhengzhou University. We quantified sRAGE, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α), interleukelin-6 (IL-6), and C-reactive protein (CPR) protein levels in the follicular fluid from 39 PCOS and 35 non-PCOS reproductive-age women. sRAGE and VEGF, TNF-α, IL-6, and CRP in follicular fluid aspirated without blood were measured by ELISA. Results sRAGE concentrations in the follicular fluid were significantly lower in the PCOS group compared to those in the control group, while VEGF, TNF-α, IL-6, and CRP concentrations were significantly higher in the PCOS group than in the control group (P < 0.05). sRAGE was significantly, inversely correlated with the total dose of gonadotropin (Gn) in the PCOS group undergoing IVF treatment (r = −0.451, P = 0.004). After adjusting for age and Gn dose (in international units used per cycle), sRAGE protein levels in the follicular fluid were significantly, inversely related to VEGF (r = −0.378, P = 0.018), TNF-α (r = −0.450, P = 0.004), IL-6 (r = −0.455, P = 0.004), and CRP (r = −0.375, P = 0.019). Conclusion sRAGE in the follicular fluid might exert a protective effect against the inflammatory action of PCOS development.

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Section: Discussionmentioning

confidence: 99%

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

Asan

Hao

Yang

et al. 2016

J Assist Reprod Genet

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“…Again, these data indicate that there is a clinical evidence for an important role for AGEs in ovarian dysfunction and poorer COH outcome in women with elevated AGEs. Another study [113] reported a significant negative correlation between serum sRAGE levels and the number of growing follicles and retrieved oocytes following COH. Women who got pregnant following COH showed significantly higher sRAGE levels in their follicular fluid compared to those who did not get pregnant.…”

Section: Controlled Ovarian Hyperstimulation In Obese Women and The Amentioning

confidence: 94%

“…We [112] and others [110,111,113] have studied the role of the AGE-RAGE system in fertility. One study [114] demonstrated that AGE-modified proteins are present on the surface of freshly isolated human granulosa lutein cells collected from women who underwent COH.…”

Section: Controlled Ovarian Hyperstimulation In Obese Women and The Amentioning

confidence: 99%

Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women?

Zhang¹,

Merhi²

2016

JED

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“…What's more, lower follicular fluid AGE levels were the most significant predictors of pregnancy outcomes (158). In another study of women undergoing IVF, follicular fluid levels of soluble form of RAGE (sRAGE) significantly correlated with conception rates (159). Finally, sRAGE seems to be positively correlated with AMH, a well-known marker of ovarian reserve (160).…”

Section: Nutrition As a Mediator Of Oxidative Stress In Female Reprodmentioning

confidence: 97%

MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

Diamanti-Kandarakis

Papalou²,

Kandaraki

et al. 2017

European Journal of Endocrinology

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Nutrition can generate oxidative stress and trigger a cascade of molecular events that can disrupt oxidative and hormonal balance. Nutrient ingestion promotes a major inflammatory and oxidative response at the cellular level in the postprandial state, altering the metabolic state of tissues. A domino of unfavorable metabolic changes is orchestrated in the main metabolic organs, including adipose tissue, skeletal muscle, liver and pancreas, where subclinical inflammation, endothelial dysfunction, mitochondrial deregulation and impaired insulin response and secretion take place. Simultaneously, in reproductive tissues, nutrition-induced oxidative stress can potentially violate delicate oxidative balance that is mandatory to secure normal reproductive function. Taken all the above into account, nutrition and its accompanying postprandial oxidative stress, in the unique context of female hormonal background, can potentially compromise normal metabolic and reproductive functions in women and may act as an active mediator of various metabolic and reproductive disorders.

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Concentrations of sRAGE in serum and follicular fluid in assisted reproductive cycles—a pilot study

Cited by 12 publications

References 0 publications

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women?

MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

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