Concentrations of thiocyanate, hypothiocyanite, ‘free’ and ‘total’ lysozyme, lactoferrin and secretory lgA in resting and stimulated whole saliva of children aged 12–14 years and the relationship with plaque accumulation and gingivitis

Jalil, R. A.; Ashley, F P; Wilson, R.F.; Wagaiyu, Evelyn

doi:10.1111/j.1600-0765.1993.tb01060.x

Cited by 40 publications

(28 citation statements)

References 18 publications

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“…[3031] The level of salivary SCN is higher in tobacco users as compared with nontobacco users. Our results are in agreement with those reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Estimation and correlation of salivary thiocyanate levels in healthy and different forms of tobacco users having chronic periodontitis: A cross-sectional biochemical study

et al. 2014

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Background:Periodontitis is a common inflammatory disease with complex and multi-factorial origin. Tobacco usage has shown its adverse effect on periodontal health. Various components within saliva not only protect the integrity of oral tissues, but also provide clues to local and systemic diseases and conditions. Salivary thiocyanate (SCN) has been shown to be a chemical indicator in smokers and smokeless tobacco users. Noninvasive nature of salivary testing has made it an attractive and effective alternative to blood and urine testing. Limited studies are there comparing and correlating the salivary SCN levels in smokers with chronic periodontitis (CP). However, no studies show correlation of salivary SCN among gutka chewers with CP.Aims and Objectives:The objective of the following study is to estimate, compare, and correlate the SCN levels in periodontally healthy, CP, smokers with CP and gutka chewers with CP subjects.Materials and Methods:Study includes 120 subjects with age 18-55 years, categorized as periodonally healthy (n = 30), CP (n = 30), smokers (n = 30), and gutka chewers (n = 30) with CP. Required clinical parameters such as gingival index, probing depth and clinical attachment loss were recorded and salivary SCN levels were estimated through ultraviolet-spectrophotometer.Results:Mean salivary SCN level were shown to be higher among smokers and gutka chewers with CP as compared to healthy and CP alone.Conclusion:The present study exhibited the significant increase in salivary SCN levels among smokers and gutka chewers when compared to others, concluding that the analysis of salivary SCN levels could be used as an adjunctive means of diagnosis.

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“…[3031] The level of salivary SCN is higher in tobacco users as compared with nontobacco users. Our results are in agreement with those reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Estimation and correlation of salivary thiocyanate levels in healthy and different forms of tobacco users having chronic periodontitis: A cross-sectional biochemical study

et al. 2014

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“…Patients with low levels of lysozyme in saliva are more susceptible to plaque accumulation, which is considered a risk factor for periodontal disease. [15]…”

Section: Salivary Markers Of Periodontal Diseasesmentioning

confidence: 99%

Saliva: A diagnostic biomarker of periodontal diseases

Patil

2011

J Indian Soc Periodontol

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Early detection of disease plays a crucial role in successful therapy. Early diagnosis and management reduces the severity and possible complications of the disease process. To overcome this challenge, medical researchers are devoted to finding molecular disease biomarkers that reveal a hidden lethal threat before the disease becomes complicated. Saliva, an important physiologic fluid, containing a highly complex mixture of substances, is rapidly gaining popularity as a diagnostic tool. Periodontal disease is a chronic disease of the oral cavity comprising a group of inflammatory conditions affecting the supporting structures of the dentition. In the field of periodontology, traditional clinical criteria are often insufficient for determining sites of active disease, for monitoring the response to therapy, or for measuring the degree of susceptibility to future disease progression. Saliva, as a mirror of oral and systemic health, is a valuable source for clinically relevant information because it contains biomarkers specific for the unique physiologic aspects of periodontal diseases. This review highlights the various potentials of saliva as a diagnostic biomarker for periodontal diseases.

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“…A variety of salivary components-e.g., secretory immunoglobulin A, mucins, proline-rich proteins, fibronectin, amylase, lysozyme, and lactoferrin-provides such host determinants for bacterial adherence and colonization in the human mouth (Jalil et al, 1992(Jalil et al, , 1993Scannapieco, 1994). The acidic, basic, and glycosylated proline-rich proteins (PRPs) are major and highly polymorphic salivary constituents which mediate bacterial adherence to oral surfaces (Gibbons and Hay, 1988;Gibbons, 1989;Lamkin and Oppenheim, 1993).…”

Section: Introductionmentioning

confidence: 98%

Agglutinin and Acidic Proline-rich Protein Receptor Patterns May Modulate Bacterial Adherence and Colonization on Tooth Surfaces

et al. 1998

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Bacterial binding to salivary proteins may in part account for individual differences in the colonization of tooth surfaces. High-molecular-weight glycoproteins, agglutinins, mediate S. mutans adherence, whereas acidic proline-rich proteins mediate adherence of other early-colonizing streptococci and Actinomyces. The aim of the present study was to examine the composition of adherence-related salivary proteins and dental plaque micro-organisms in three individuals with a low, moderate, and high capacity to mediate S. mutans adherence. The S. mutans (strain Ingbritt) binding activity resided with a 300-kDa agglutinin which was six-fold more prevalent in the high S. mutans binding saliva compared with the low one. Binding to all three salivas was completely blocked by a monoclonal anti-agglutinin antibody. The moderate S. mutans binding saliva was found to contain adherence-inhibiting components. Furthermore, the low and moderate S. mutans binding salivas mediated binding of A. naeslundii strain LY7 to a greater extent than the saliva with high S. mutans binding. The A. naeslundii binding activity resided with the acidic proline-rich proteins (APRPs) and paralleled the relative content of 106- and 150-residue APRPs. Low A. naeslundii binding coincided with an almost two-fold higher ratio of 106/150 APRPs compared with the high A. naeslundii binding saliva. During conventional gel filtration, a degradation of the acidic, basic, and glycosylated proline-rich proteins was evident in the saliva with high S. mutans and low A. naeslundii binding. This saliva donor had a comparably high rate of dental plaque formation, high counts of S. mutans, and low counts of other streptococci and Actinomyces.

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Concentrations of thiocyanate, hypothiocyanite, ‘free’ and ‘total’ lysozyme, lactoferrin and secretory lgA in resting and stimulated whole saliva of children aged 12–14 years and the relationship with plaque accumulation and gingivitis

Cited by 40 publications

References 18 publications

Estimation and correlation of salivary thiocyanate levels in healthy and different forms of tobacco users having chronic periodontitis: A cross-sectional biochemical study

Estimation and correlation of salivary thiocyanate levels in healthy and different forms of tobacco users having chronic periodontitis: A cross-sectional biochemical study

Saliva: A diagnostic biomarker of periodontal diseases

Agglutinin and Acidic Proline-rich Protein Receptor Patterns May Modulate Bacterial Adherence and Colonization on Tooth Surfaces

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