Concentrations of trace elements in bones of the hip joint from patients after hip replacement surgery

Lanocha, Natalia; Kalisińska, Elżbieta; Kosik-Bogacka, Danuta; Budis, Halina; Sokolowski, Sebastian; Bohatyrewicz, Andrzej

doi:10.1016/j.jtemb.2011.11.006

Cited by 42 publications

(62 citation statements)

References 31 publications

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“…Zn levels were significantly lower in females than males, while Mn levels were significantly higher. Contrary to previous reports, we detected no other correlation or Ca:Mg-ratio variation according to levels of other trace elements 40–42…”

Section: Discussioncontrasting

confidence: 99%

Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis

Karaaslan

Mutlu

Mermerkaya

et al. 2014

CIA

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PurposeThis study examined the role of trace elements in osteoporosis by comparing the trace-element concentrations in bone and the radiographic bone density and bone mineral density (BMD) of patients with osteoporotic femur fractures and osteoarthritis.Patients and methodsThe study enrolled 30 patients operated on for proximal femoral fractures after falls, and another 30 patients undergoing hip arthroplasty at the same center for hip osteoarthritis. Bone samples were obtained during the surgical procedures. The density of the bone samples was assessed using computed tomography and the Hounsfield scale. The levels of Ca(II), Mg(II), and other trace elements in the bone samples were determined using flame atomic absorption spectrometry and inductively coupled plasma mass spectrometry. In addition, BMD, Z-scores, and T-scores were measured in the unaffected hips of all patients using dual-energy X-ray absorptiometry.ResultsMagnesium (1,908±507 versus 2,540±435, P<0.05), calcium (10.4±3.5 versus 13.9±3.7, P<0.05), and zinc (2,342±1,252 versus 3,145±1,604, P<0.05) μg g−1, levels were significantly lower in the bone samples in the fracture group. The groups did not differ in the other biochemical parameters. All dual-energy X-ray absorptiometry findings were significantly worse in the fracture group than in the osteoarthritis group. However, the groups did not differ in femoral neck density assessed radiologically using the Hounsfield scale. The following parameters were negatively correlated with age: magnesium, r=−0.436, P<0.001; calcium, r=−0.331, P=0.01; T-score, r=−0.381, P=0.003; Z-score, r=−0.267, P=0.043; and BMD, r=−0.365, P=0.004.ConclusionCa(II), Mg(II), and Zn(II) appear to play important roles in bone breakdown/synthesis. Further studies of the roles of trace elements in the etiology and treatment of osteoporosis are warranted. We found decreased bone levels of Ca, Mg, and Zn in patients with osteoporotic fractures compared to subjects with osteoarthritis.

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Section: Discussioncontrasting

confidence: 99%

Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis

Karaaslan

Mutlu

Mermerkaya

et al. 2014

CIA

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“…Mercury is mainly used in the production of biocides, batteries, and dental amalgam fillings in industrial electrolysis and in the extraction of gold. However, most of this metal (in the form of Hg 0 vapor) is emitted into the atmosphere via fossil fuel-based production of electricity (coal, lignite, and crude oil burning) (Lanocha et al 2013). The toxicity of mercury varies depending on its form, dose, and rate of exposure (Nordberg et al 2014).…”

Section: Introductionmentioning

confidence: 99%

An analysis of factors affecting the mercury content in the human femoral bone

Zioła-Frankowska

Dąbrowski

Kubaszewski

et al. 2016

Environ Sci Pollut Res

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The study was carried out to determine the content of mercury in bone tissue of the proximal femur (head and neck bone) of 95 patients undergoing total hip replacement due to osteoarthritis, using CF-AFS analytical technique. Furthermore, the investigations were aimed at assessing the impact of selected factors, such as age, gender, tobacco smoking, alcohol consumption, exposure to chemical substance at work, type of degenerative changes, clinical evaluation and radiological parameters, type of medications, on the concentration of mercury in the head and neck of the femur, resected in situ. Mercury was obtained in all samples of the head and neck of the femur (n = 190) in patients aged 25-91 years. The mean content of mercury for the whole group of patients was as follows: 37.1 ± 35.0 ng/g for the femoral neck and 24.2 ± 19.5 ng/g for the femoral head. The highest Hg contents were found in femoral neck samples, both in women and men, and they amounted to 169.6 and 176.5 ng/g, respectively. The research showed that the mercury content of bones can be associated with body mass index, differences in body anatomy, and gender. The uses of statistical analysis gave the possibility to define the influence of factors on mercury content in human femoral bones.

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“…Animal studies have suggested that comparable degrees of lead exposure have toxic effects on skeletal tissue and fracture healing [3,4,6,15,16,18,[20][21][22][23]. In addition, clinical studies are present in the literature demonstrating deleterious effects on bone healing, bone remodeling, and skeletal development [5,12,14]. The concentrations of lead reported in 38% of our specimens have been shown to be osteotoxic in some studies and related to clinical variation in bone health in patients in development and in the setting of fracture healing.…”

Section: Discussionmentioning

confidence: 81%

“…Lead is a known osteotoxic substance that is preferentially stored in bone for decades and may impact the quality of bone used as graft materials from donors with a history of exposure [2,4,14]. Lead has been shown to have deleterious effects on bone formation and cellular remodeling at concentrations as low as 2 parts per million [6,18,20].…”

Section: Discussionmentioning

confidence: 99%

Allogeneic and Autogenous Bone Grafts Are Affected by Historical Donor Environmental Exposure

Behrend

Carmouche

Millhouse

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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Background Bone graft materials are routinely evaluated for infectious agents; however, data regarding contamination of bone graft from environmental exposure of the donors to osteotoxic substances such as lead are not routinely available. In animal models, stored lead in bone has been shown to impair fracture healing and osteocyte function. In clinical studies, lead is linked to skeletal disease at relatively low concentrations. Presumably the levels of lead in allografts mirror the level of lead in bone in the population; however, the degree to which processing might decrease this and the frequency with which potentially osteotoxic levels appear in bone grafts have not been studied. Questions/purposes (1) Does processing of donor bone for allografts result in lower concentrations of lead in commercial allograft when compared with autologous bone graft; and (2) what proportion of bone grafts contain potentially osteotoxic levels of lead from[2.0 to 20.0 lg/g corresponding to environmental exposure? Methods Allograft from commercial sources and autologous bone graft materials were examined for lead content using ICP-atomic absorption spectrophotometric analysis. We analyzed bone graft specimens from 42 donors, including 26 corticocancellous tibial specimens from commercially available bone graft materials and 16 autograft corticocancellous tibial specimens. Lead levels were determined for the cortical (n = 42) and cancellous (n = 42) portions of each specimen. For quality control, all instru-

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Concentrations of trace elements in bones of the hip joint from patients after hip replacement surgery

Cited by 42 publications

References 31 publications

Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis

Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis

An analysis of factors affecting the mercury content in the human femoral bone

Allogeneic and Autogenous Bone Grafts Are Affected by Historical Donor Environmental Exposure

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