Concentrations of vitamin C, vitamin B12 and folic acid in patients treated with hemodialysis and on-line hemodiafiltration or hemofiltration

Fehrman-Ekholm, Ingela; Lotsander, Agneta; Logan, K.W.; Dunge, David; Odar‐Cederlöf, Ingegerd; Kallner, Anders

doi:10.1080/00365590701514266

Cited by 39 publications

(36 citation statements)

References 11 publications

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“…Previous studies have shown that serum folate concentrations are lower in HD patients in comparison with that of the general population [3]. In contrast, serum B12 concentrations in HD patients have been reported as being similar to or higher than that of the normal range due to B12's larger molecular size and its subsequent difficulty in being cleared during HD [5,6]. …”

Section: Introductionmentioning

confidence: 71%

Association of serum vitamin B12 and folate with mortality in incident hemodialysis patients

Soohoo

Ahmadi

Qader

et al. 2016

Nephrology Dialysis Transplantation

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A B S T R A C TBackground: Vitamin B12 (B12) and folate are essential vitamins that play important roles in physiological processes. In the general population, many studies have evaluated the association of these vitamins with clinical outcomes, yet this association in hemodialysis (HD) patients remains unclear. Methods: We examined the association of serum folate and B12 with mortality in a 5-year cohort of 9517 (folate) and 12 968 (B12) HD patients using Cox models with hierarchical adjustment for sociodemographics, comorbidities, and laboratory variables associated with the malnutrition and inflammation complex syndrome. The associations of baseline B12 and folate (separately) with all-cause mortality were evaluated across five categories of B12 [<400 (reference), 400-<550, 550-<650, 650-<750 and !750 pg/mL] and folate [<6.2, 6.2-<8.4, 8.4-<11 (reference), 11-<14.3 and !14.3 ng/mL]. Results: The study cohort with B12 measurements had a mean 6 standard deviation age of 63 6 15 years, among whom 43% were female, 33% were African-American, and 57% were diabetic. Higher B12 concentrations !550 pg/mL were associated with a higher risk of mortality after adjusting for sociodemographic and laboratory variables. However, only lower serum folate concentrations <6.2 ng/mL were associated with a higher risk of all-cause mortality when adjusted for sociodemographic variables [adjusted hazard ratio (95% confidence-interval): 1.18 (1.03-1.35)]. Conclusions: Higher B12 concentrations are associated with higher all-cause mortality in HD patients independent of sociodemographics and laboratory variables, whereas lower folate concentrations were associated with higher all-cause mortality after accounting for sociodemographic variables. Further studies are warranted to determine the optimal B12 and folate level targets in this population.

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Section: Introductionmentioning

confidence: 71%

Association of serum vitamin B12 and folate with mortality in incident hemodialysis patients

Soohoo

Ahmadi

Qader

et al. 2016

Nephrology Dialysis Transplantation

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“…Surely, both patient sera had excess amounts of vitamin B 12 given the fact that they were on high doses of supplementation with compromised urinary output. Though the patients were on frequent hemodialysis, the excess vitamin B 12 concentration in the sera could be explained from the findings of Ferhman-Eckholm et al where serum cyanocobalamin levels have been shown to remain unaltered even after hemodialysis [2].…”

Section: Discussionmentioning

confidence: 95%

Vitamin B12 Immunoassay on Roche Elecsys 2010: Effects of High Excess Concentration of Serum Vitamin B12 in CKD Patients on Parenteral Administration

Basu

Chaudhuri

2011

Ind J Clin Biochem

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“…Vitamins are needed. Especially C-vitamins since they are removed at hemodialysis or hemofiltration (Fehrman-Ekholm et al 2008). D-vitamins are needed for the skeleton and in treatment of secondary hyperparathyroidism.…”

Section: Nutrition and Exercisementioning

confidence: 99%

The Importance of Exercise Programs in Haemodialysis Patients

Heiwe¹,

Ekholm²,

Fehrman-Ekholm³

2011

Progress in Hemodialysis - From Emergent Biotechnology to Clinical Practice

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Concentrations of vitamin C, vitamin B12 and folic acid in patients treated with hemodialysis and on-line hemodiafiltration or hemofiltration

Abstract: P-ascorbate was reduced by both dialysis and filtration treatments. Neither S-cobalamin nor S-folate were reduced by dialysis or filtration treatments.

Cited by 39 publications

References 11 publications

Association of serum vitamin B12 and folate with mortality in incident hemodialysis patients

Association of serum vitamin B12 and folate with mortality in incident hemodialysis patients

Vitamin B12 Immunoassay on Roche Elecsys 2010: Effects of High Excess Concentration of Serum Vitamin B12 in CKD Patients on Parenteral Administration

The Importance of Exercise Programs in Haemodialysis Patients

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