2017
DOI: 10.1002/jbio.201700073
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Concentric photothermal coagulation with basket‐integrated optical device for treatment of tracheal stenosis

Abstract: A basket‐integrated optical device is developed to consistently treat tubular tissue by centering an optical diffuser in the lumen. Four nitinol arms in conjunction with the optical diffusing applicator are deployed to induce homogeneous circumferential light emission and concentric photothermal coagulation on tracheal tissue. A 1470‐nm laser light is employed for the tissue testing at various irradiation conditions and evaluated in terms of thermal gradient and temperature evolution. Preliminary experiments o… Show more

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Cited by 9 publications
(3 citation statements)
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“…Image J (National Institute of the Health, Bethesda, Maryland, USA) was used to measure the HeNe light intensities for quantitative analysis. All the acquired data were filtered to remove low-pass signals and to smooth out the intensity profiles for comparative analysis [26]. The beam radius (or the standard deviation of Gaussian beam) at the surface of the tissue was determined by the position where the optical intensity drops to 1/e 2 (13.5%) of the maximum intensity.…”
Section: Fiber Preparationmentioning
confidence: 99%
See 1 more Smart Citation
“…Image J (National Institute of the Health, Bethesda, Maryland, USA) was used to measure the HeNe light intensities for quantitative analysis. All the acquired data were filtered to remove low-pass signals and to smooth out the intensity profiles for comparative analysis [26]. The beam radius (or the standard deviation of Gaussian beam) at the surface of the tissue was determined by the position where the optical intensity drops to 1/e 2 (13.5%) of the maximum intensity.…”
Section: Fiber Preparationmentioning
confidence: 99%
“…The transient temperature rise was then calculated by dividing the elevated temperature by the corresponding exposure time (i.e., total time to reach maximum temperature). Prior to the IR measurements, liver emissivity was set to be 0.98 to calibrate the camera according to the instructions from the manufacturer's manual [26]. To protect the IR camera from any over-exposure effects, a neutral-density filter was situated in-between the tissue and the camera.…”
Section: Experimental Set-upmentioning
confidence: 99%
“…On the other hand, the current study applies a diffusing applicator with circumferential light emissions for laser ablation of pancreas in order to overcome the limitations of the end-firing flat fiber and to treat the tissue uniformly via cylindrical interstitial laser ablation (CILA; Figure 1(a); bottom). Unlike the end-firing flat fiber (forward emission), the diffusing applicator can provide a lower power density (38 W/cm 2 at 5 W) because of a wide light coverage, which is capable of ablating a large volume of the targeted tissue with no excessive heating and no or minimal tissue carbonization [18][19][20]. Hence, the aim of the current study is to demonstrate a therapeutic capability of multiple CILAs to ablate a wide range of pancreatic tissue volumes at various power levels in both ex vivo and in vivo porcine models and to develop an EUS-guided multiple CILAs to treat the largesized PC (target volume ¼ 2 $ 5 cm 3 ) with enhanced safety.…”
Section: Introductionmentioning
confidence: 99%