Concepts and Methodology of Interaction of Carbon Nanostructures with Cellular Systems

Sciatic nerve repair using poly(ε‐caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene

“…Nevertheless, the balance provided by mixing PCL with NPC and NPG results in a biofunctional nanocomposite that allowed only a thin layer of tissue covering, what possibly facilitated the regenerative process. In this regard, nanostructures of carbon, due to their negative charge, may facilitate the initial steps of cell adhesion and proliferation (Bergethon, Trinkaus-Randall, & Franzblau, 1989;Lee, Cuddihy, & Kotov, 2008;Oliveira et al, 2014;Zhu et al, 2010). As a result, significant larger nerve bridges were found within PCL + NPC + NPG tubes, which presented greater number of myelinated axons.…”

“…A carbon nanotube is characterized by rolling one or more graphene sheets concentrically with a diameter of nanometric dimensions and hollow inner cavity (de Oliveira, Ceragioli, & Assaf, 2014).…”

“…Carbon nanotubes are considered key materials and have many possibilities for technological applications due to properties such as high chemical resistance, oxidation and temperature resistance, low density, electrical conductivity, mechanical strength, and flexibility (de Oliveira et al, 2014). All these features make them excellent devices for neural implants, helping structurally and functionally for regeneration of damaged axons (Kotov et al, 2009;Sun, Sun, Li, & Peng, 2013).…”