The two main energy consumers within a manufacturing plant are the HVAC systems and manufacturing processes. Studies have predominately looked at energy demand associated with manufacturing a single product or a production line, as well as analysis of energy use within a building, but little work has investigated the interaction between manufacturing processes and the surrounding building. Dynamic time based building energy simulation was used to determine the thermal behaviour of the manufacturing facility. The study establishes the importance of analysing manufacturing energy flows alongside that of the building in order to capture all thermal and energy flows. The relationship between the energy demand of HVAC systems with manufacturing productivity is determined. The use of the current degreeday method of building analysis was proven inappropriate for manufacturing facilities, due to such significant heat gains from manufacturing equipment, and impact of equipment on indoor conditions. The need for a proactive HVAC system based on manufacturing demand is introduced, allowing for control of the environment prior to significant temperature or humidity changes.