Concepts of Nanoparticle Dose Metric and Response Metric

Oberdörster, Günter; Oberdörster, Eva; Oberdörster, Jan

doi:10.1289/ehp.115-1892118

Cited by 88 publications

(79 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Discrete nanoparticles (35-37-nm median diameter) that deposit in the nasal region may be able to enter the brain by translocation along the olfactory nerve, as was observed in rats Oberdörster et al 2005a;Elder et al 2006]. The transport of insoluble particles from 20-500 nm-diameter to the brain via sensory nerves (including olfactory and trigeminus) was reported in earlier studies in several animal models [De Lorenzo 1970;Adams and Bray 1983;Hunter and Dey 1998].…”

mentioning

confidence: 70%

“…Experimental studies in rodents and cell cultures have shown that the toxicity of ultrafine or nanoparticles is greater than that of the same mass of larger particles of similar chemical composition [Oberdörster et al , 1994aLison et al 1997;Tran et al 1999Tran et al , 2000Brown et al 2001;Barlow et al 2005;Duffin et al 2007]. In addition to particle surface area, other particle characteristics may influence toxicity, including surface functionalization or coatings, solubility, shape, and the ability to generate oxidant species and to adsorb biological proteins or bind to receptors [Duffin et al 2002;Oberdörster et al 2005a;Maynard and Kuempel 2005;Donaldson et al 2006]. More research is needed on the influence of particle properties on interactions with biological systems and the potential for adverse effects.…”

Section: Aggregatementioning

confidence: 99%

“…In contrast, aged PTFE fume was much less toxic and did not result in mortality. This low toxicity was attributed to the increase in particle size from accumulation and to changes in surface chemistry [Johnston et al 2000;Oberdörster et al 2005a]. Human case studies have reported pulmonary edema in workers exposed to PTFE fume and an accidental death in a worker when an equipment malfunction caused overheating of the PTFE resin and release of the PTFE pyrolysis products in the workplace [Goldstein et al 1987;Lee et al 1997].…”

Section: Polytetrafluoroethylene Fumementioning

confidence: 99%

“…These hypotheses are based on the scientific literature of particle exposures in animals and humans. This literature has been recently reviewed [Donaldson et al 2005;Maynard and Kuempel 2005;Oberdörster et al 2005a, Donaldson et al 2006Kreyling et al 2006]. In general, the particles used in past studies have not been characterized to the extent recommended for new studies in order to more fully understand the physicochemical properties of the particles that influence toxicity [Oberdörst-er et al 2005b;Thomas et al 2006].…”

Section: Hypotheses From Animal and Epidemiological Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Approaches to safe nanotechnology managing the health and safety concerns associated with engineered nanomaterials.

Hodson¹,

Methner²,

Zumwalde³

2009

View full text Add to dashboard Cite

To receive documents or other information about occupational safety and health topics, contact NIOSH at Telephone: 1-800-CDC-INFO (1-800-232-4636) TTY: 1-888-232-6348 E-mail: cdcinfo@cdc.gov or visit the NIOSH Web site at www.cdc.gov/niosh.For a monthly update on news at NIOSH, subscribe to NIOSH eNews by visiting www.cdc.gov/niosh/eNews. No. 2009-125 March 2009 DHHS (NIOSH) Publication Safer • Healthier • People™Approaches to Safe Nanotechnology iii Nanotechnology-the manipulation of matter on a near-atomic scale to produce new structures, materials, and devices-offers the promise of unprecedented scientific advancement for many sectors, such as medicine, consumer products, energy, materials, and manufacturing. Nanotechnology has the power not only to improve existing technologies, but to dramatically enhance the effectiveness of new applications.Research on the potential applications of nanotechnology continues to expand rapidly worldwide. New nanotechnology consumer products emerge at a rate of three to four per week. Over the course of the next decade, nanotechnology could have a $1 trillion impact on the global economy and employ two million workers-half of them residing in the U.S.While nanomaterials present seemingly limitless possibilities, they bring with them new challenges to understanding, predicting, and managing potential safety and health risks to workers. The National Institute for Occupational Safety and Health (NIOSH) remains committed to protecting workers now and in the future, as nanotechnology applications and uses expand.As part of these efforts, in October 2005, NIOSH released for public comment the draft document, Approaches to Safe Nanotechnology: An Information Exchange with NIOSH. Based on feedback received, NIOSH revised and updated the document in July 2006 and sought further public comment. This draft report has been widely cited, and the final version of the report should serve as a vital resource for stakeholders (including occupational safety and health professionals, researchers, policy makers, risk assessors, and workers in the industry) who wish to understand more about the safety and health implications of nanotechnology in the workplace.With the publication of the Approaches to Safe Nanotechnology document, NIOSH hopes to: raise awareness of the occupational safety and health issues involved with nanotechnology; make recommendations on occupational safety and health best practices in the production and use of nanomaterials; facilitate dialogue between NIOSH and its external partners in industry, labor and academia; respond to requests for authoritative safety and health guidelines; and, identify information gaps and areas for future study and research.As our knowledge of nanoscience increases, so too will our efforts to provide valuable guidance on the safe handling of nanoparticles and for protecting the lives and livelihoods of nanotechnology workers.

show abstract

mentioning

confidence: 70%

Section: Aggregatementioning

confidence: 99%

Section: Polytetrafluoroethylene Fumementioning

confidence: 99%

Section: Hypotheses From Animal and Epidemiological Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Approaches to safe nanotechnology managing the health and safety concerns associated with engineered nanomaterials.

Hodson¹,

Methner²,

Zumwalde³

2009

View full text Add to dashboard Cite

show abstract

“…Recent studies examining the toxicity of engineered nanomaterials in cell cultures and animals have shown that size, surface area, surface chemistry, solubility and possibly shape all play a role in determining the potential for engineered nanomaterials to cause harm [33] Three issues stand out as fertile ground for innovative research: monitors for airborne exposure, detectors for waterborne nanomaterials, and smart sensors that can measure both exposure and potential hazards. A global understanding of nanotechnology-specific risks is essential if large and small industries are to operate on a level playing field, and developing economies are not to be denied essential information on designing safe nanotechnologies.…”

Section: Nanotechnology: the Risksmentioning

confidence: 99%

A Review on Nanotechnology in Cancer Treatment

Mishra¹

2017

WJPPS

View full text Add to dashboard Cite

Nanotechnology is the study and use of structures between 1 nanometer and 100 nanometers in size. Cancer is the leading cause of death among people younger than 85 years. Nanoparticles that deliver chemotherapy drugs directly to cancer cells are under development.Nanomedicine application areas includes drug delivery, therapy, diagonistic, imaging and antimicrobial techniques. Fears over the possible dangers of some nanotechnologies have started growing. This article aims at giving an overview of the present status of nanotechnology in cancer therapy.

show abstract

Toxicity of different‐sized copper nano‐ and submicron particles and their shed copper ions to zebrafish embryos

Hua

Vijver

Ahmad

et al. 2014

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Three sizes of copper nanoparticles (Cu NPs; 25 nm, 50 nm, and 100 nm), 1 submicron-sized particle, and Cu(NO3 )2 were added to the culture buffer of zebrafish embryos from 24 h postfertilization to 120 h postfertilization. In suspensions of Cu NPs and the Cu submicron-sized particle, the main contribution to the toxicity to zebrafish embryos was from the particle form of Cu particles (Cu NPparticle , >71%) rather than from dissolved Cu from the Cu particles (Cu NPion ). All particles tested as well as copper nitrate inhibited hatching, altered behavioral responses, and increased the incidence of malformations. Different kinds of abnormalities were observed in the morphology and behavior of the zebrafish embryos, depending on the particle size of the Cu suspensions tested. The median lethal concentrations of Cu NPparticle (25 nm, 50 nm, and 100 nm), the submicron-sized particle, and copper nitrate were 0.58 mg/L, 1.65 mg/L, 1.90 mg/L, 0.35 mg/L, and 0.70 mg/L, respectively. Submicron-sized particles and copper nitrate were more toxic than Cu NPs, and smaller Cu NPs were more toxic than larger Cu NPs. Dissolution of Cu NPs and the subsequent ion toxicity was not the primary mechanism of Cu NP toxicity in zebrafish embryos.

show abstract

Concepts of Nanoparticle Dose Metric and Response Metric

Cited by 88 publications

References 5 publications

Approaches to safe nanotechnology managing the health and safety concerns associated with engineered nanomaterials.

Approaches to safe nanotechnology managing the health and safety concerns associated with engineered nanomaterials.

A Review on Nanotechnology in Cancer Treatment

Toxicity of different‐sized copper nano‐ and submicron particles and their shed copper ions to zebrafish embryos

Contact Info

Product

Resources

About