Conceptual and commercially available intravaginal veterinary drug delivery systems

Rathbone, Michael J.; Macmillan, K.L.; Bunt, Craig R.; Burggraaf, Shane

doi:10.1016/s0169-409x(97)00089-6

Cited by 41 publications

(10 citation statements)

References 221 publications

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“…Then, the silicone matrix is cured inside the mold, so that it becomes an elastic semisolid. It is removed from the mold and formed into a coil with a diameter of approximately 4 cm and a length of approximately 12 cm (Rathbone et al, 1997). Figure 1 shows a scheme of a PRID.…”

Section: Intravaginal Delivery Systemsmentioning

confidence: 99%

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Technological Evolution of Hormone Delivery Systems for Estrous Synchronization in Cattle

Weibel¹,

Badano²,

Rintoul³

2014

Int. J. Livest. Res.

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Section: Intravaginal Delivery Systemsmentioning

confidence: 99%

“…Although, it has been initially designed for cows, with minor modifications it can be also used in mares (Rathbone et al, 1997).…”

Section: Intravaginal Delivery Systemsmentioning

confidence: 99%

Technological Evolution of Hormone Delivery Systems for Estrous Synchronization in Cattle

Weibel¹,

Badano²,

Rintoul³

2014

Int. J. Livest. Res.

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“…In humans, progesterone is used in menopausal hormone replacement therapy , and in oral contraception pills. In veterinary, it is used to control the estrous cycle in livestock for artificial insemination in planned conception . The polymorphism of progesterone has been studied since 1959 when 5 polymorphs were identified by hot‐stage microscopy .…”

Section: Introductionmentioning

confidence: 99%

Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (PIHn) method

Araya-Sibaja

Soldi

Campos

et al. 2015

Crystal Research and Technology

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The selective crystallization of progesterone polymorphs prepared by Polymer-Induced Heteronucleation (PIHn) method was investigated. Polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), dextran, gelatin, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as heteronucleants. Crystallizations were conducted from 0.5, 10 and 40 mg mL −1 solutions in chloroform at room temperature by solvent evaporation. The samples were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy and scanning electron microscopy. Form 2 was obtained from 0.5 mg mL −1 solution in almost all polymers. A mixture of both polymorphs crystallized from the three concentrations on gelatine; from 10 and 40mg mL −1 on PVA and HPMC and, from 10 mg mL −1 solutions on NBR. Form 2 crystallized on HPMC was stable for three months under ambient stress conditions (40ºC and 75% RH). These results are good evidence that the tailoring of new formulations and devices with progesterone the metastable and more soluble form 2 is possible.

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“…The vagina of livestock animals, such as cattle and sheep, is an attractive site for drug delivery because of the easiness with which drugs are administered, the easiness to remove the system as well (if it is not biodegradable), and its ability to retain drug delivery systems for prolonged periods (weeks) (37). Intravaginal veterinary drug delivery systems have been studied and developed for the administration of synthetic and natural hormones such as progesterone, methyl acetoxy progesterone, fluorogestone acetate, and estradiol benzoate (38)(39)(40).…”

Section: Introductionmentioning

confidence: 99%

Modeling of Progesterone Release from Poly(3-Hydroxybutyrate) (PHB) Membranes

et al. 2015

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Abstract. Poly(3-hydroxybutyrate) (PHB) biodegradable polymeric membranes were evaluated as platform for progesterone (Prg)-controlled release. In the design of new drug delivery systems, it is important to understand the mass transport mechanism involved, as well as predict the process kinetics. Drug release experiments were conducted and the experimental results were evaluated using engineering approaches that were extrapolated to the pharmaceutical field by our research group. Membranes were loaded with different Prg concentrations and characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). SEM images showed that membranes have a dense structure before and after the progesterone addition. DSC and FTIR allowed determining the influence of the therapeutic agent in the membrane properties. The in vitro experiments were performed using two different techniques: (A) returning the sample to the receptor solution (constant volume of the delivery medium) and (B) extracting total volume of the receptor solution. In this work, we present a simple and accurate Blumped^second-order kinetic model. This lumped model considers the different mass transport steps involved in drug release systems. The model fits very well the experimental data using any of the two experimental procedures, in the range 0≤t≤∞ or 0≤M t ≤M ∞ . The drug release analysis using our proposed approaches is relevant for establishing in vitro--in vivo correlations in future tests in animals.

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Conceptual and commercially available intravaginal veterinary drug delivery systems

Cited by 41 publications

References 221 publications

Technological Evolution of Hormone Delivery Systems for Estrous Synchronization in Cattle

Technological Evolution of Hormone Delivery Systems for Estrous Synchronization in Cattle

Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (PIHn) method

Modeling of Progesterone Release from Poly(3-Hydroxybutyrate) (PHB) Membranes

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