In this paper, we study the effect of winglet Toe & Twist angle on the wing of the aircraft aerodynamics performances and how to improve it, we analyze the aerodynamics properties of the wing with winglets with Cant angle 60 o and winglet span = 3.5 m, we test wings with different toe angles (+10 o , +5 o , 0 o , -5o, and -10 o ) and twisted angles (+5 o , 0 o , and +5 o ) and all model are tested for four Angle of attack AOA (0 o , 3 o , 6 o , and 9 o ). Then calculate the value of L/D to decide which wing has a high value of lift and lower drag. All models of a wing (sixty models) are drawn for 3D using the SOLIDWORKS program where we used Boeing 737-800 wing dimensions. Then all models of a wing were analyzed using ANSYS FLUENT.