As part of the United States Advanced Manned Launch System study to determine a follow-on, or complement, to the Space Shuttle, a reusable single-stage-to-orbit concept utilizing dual-fuel rocket propulsion has been examined. Several dual-fuel propulsion concepts were investigated. These include: a separate-engine concept combining Russian RD-170 kerosene-fueled engines with space shuttle main engine-derivative engines; the keroseneand hydrogen-fueled Russian RD-701 engine; and a dual-fuel, dual-expander engine. Analysis to determine vehicle weight and size characteristics was performed using conceptual-level design techniques. A response-surface methodology for multidisciplinary design was utilized to optimize the dual-fuel vehicles with respect to several important propulsion-system and vehicle design parameters in order to achieve minimum empty weight. The tools and methods employed in the analysis process are also summarized. In comparison with a reference hydrogenfueled single-stage vehicle, results showed that the dual-fuel vehicles were from 10 to 30% lower in empty weight for the same payload capability, with the dual-expander engine types showing the greatest potential. = chamber pressure, psia sc = staged combustion (THc)fr = fraction of lift-off thrust generated by hydrocarbon-fueled engines T W = thrust-to-weight ratio T Wa = thrust-to-gross-weight ratio T_ = sea level thrust, lb Two = vacuum thrust, lb V = incremental velocity, ft/s Y = response-surface value y = configuration variable value = nozzle expansion ratio eSSME = SSME nozzle expansion ratio