Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases

Louridas, George; Lourida, Katerina G.

doi:10.3390/healthcare5010010

Cited by 12 publications

(13 citation statements)

References 74 publications

(100 reference statements)

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“…Concepts of systems biology: bottom-up and top-down directions; disciplines (complex networks); emergence of new properties; constraints application (robustness). (Revised from: [5]).…”

Section: Figurementioning

confidence: 99%

“…The present paper discusses the constraint-based concept of SB as it is applicable to clinical cardiology and to the important clinical limitations that are present in the current practice of personalized medicine [5]. Constraints' application to clinical decisions augments robustness to the unremittingly progressive clinical course of chronic cardiac diseases.…”

Section: Introductionmentioning

confidence: 99%

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Constraints in Clinical Cardiology and Personalized Medicine: Interrelated Concepts in Clinical Cardiology

Lourida

Louridas

2021

Cardiogenetics

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Systems biology is established as an integrative computational analysis methodology with practical and theoretical applications in clinical cardiology. The integration of genetic and molecular components of a disease produces interacting networks, modules and phenotypes with clinical applications in complex cardiovascular entities. With the holistic principle of systems biology, some of the features of complexity and natural progression of cardiac diseases are approached and explained. Two important interrelated holistic concepts of systems biology are described; the emerging field of personalized medicine and the constraint-based thinking with downward causation. Constraints in cardiovascular diseases embrace three scientific fields related to clinical cardiology: biological and medical constraints; constraints due to limitations of current technology; and constraints of general resources for better medical coverage. Systems healthcare and personalized medicine are connected to the related scientific fields of: ethics and legal status; data integration; taxonomic revisions; policy decisions; and organization of human genomic data.

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“…Concepts of systems biology: bottom-up and top-down directions; disciplines (complex networks); emergence of new properties; constraints application (robustness). (Revised from: [5]).…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Constraints in Clinical Cardiology and Personalized Medicine: Interrelated Concepts in Clinical Cardiology

Lourida

Louridas

2021

Cardiogenetics

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“…The fields of epigenomics, metabolomics, proteomics, and transcriptomics are likely to yield data useful in personalizing the treatment of hypertension. This combined information not only determines the genetic susceptibility of the person, but also monitors his/her real-time physiological states [ 67 ].…”

Section: Challenges Opportunities and Future Directionsmentioning

confidence: 99%

“…In order to fully understand the rationale and hence the impact of precision medicine, it is important to know the fundamentals of systems biology [ 57 , 67 ]. Systems biology is the study of systems of biological components (i.e.…”

Section: Introducing a New Paradigm For Cardiovascular Prevention Andmentioning

confidence: 99%

Personalized medicine—a modern approach for the diagnosis and management of hypertension

et al. 2017

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The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage. Despite reductions in major risk factors and the availability of a plethora of effective antihypertensive drugs, the control of blood pressure to target values is still poor due to multiple factors including apparent drug resistance and lack of adherence. An explanation for this problem is related to the current reductionist and ‘trial-and-error’ approach in the management of hypertension, as we may oversimplify the complex nature of the disease and not pay enough attention to the heterogeneity of the pathophysiology and clinical presentation of the disorder. Taking into account specific risk factors, genetic phenotype, pharmacokinetic characteristics, and other particular features unique to each patient, would allow a personalized approach to managing the disease. Personalized medicine therefore represents the tailoring of medical approach and treatment to the individual characteristics of each patient and is expected to become the paradigm of future healthcare. The advancement of systems biology research and the rapid development of high-throughput technologies, as well as the characterization of different –omics, have contributed to a shift in modern biological and medical research from traditional hypothesis-driven designs toward data-driven studies and have facilitated the evolution of personalized or precision medicine for chronic diseases such as hypertension.

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“…Chronic complex diseases are multifarious in origin with a variety of biologically culpable components and environmental factors being implicated. Complex diseases are clinically progressive through multiple interactions between the involved components and environmental parameters [5].…”

Section: Introductionmentioning

confidence: 99%

Epstein - Barr virus Reactivation Associated with an Increased Thymidine Kinase and Normalized by an Immuno Modulatory Nano-Therapy: Three Case Reports

2018

JCEI

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Epstein-Barr Virus (EBV), a common human herpes virus known to infect most of the world population, has been mentioned in the context of many diverse human pathologies while its participation during its latency phase is more and more often demonstrated in a growing number of chronic malignancies.The biological diagnosis of the virus activity is carried out using serological parameters on the one hand, and the measurement of the viral load on the other hand. Thymidine kinase (TK) is a key enzyme in the regulation of the intranuclear thymidine pool during cell cycle progression. The rise in its plasma level therefore systematically reveals an uncontrolled cellular proliferation evoking, of course, at first a neoplastic process. Nevertheless, EBV being a DNA virus, its reactivation or even a persistent primary infection are also likely to cause an increase in the blood level of TK.Using three examples, we will show that the neutralization of EBV by an immunomodulatory nano-therapy called Bio Immune (G)ene Medicine (BI(G)MED), is accompanied by a normalization of plasma levels of TK, thus underlining the close link between the virus and this marker of cell proliferation.

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Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases

Cited by 12 publications

References 74 publications

Constraints in Clinical Cardiology and Personalized Medicine: Interrelated Concepts in Clinical Cardiology

Constraints in Clinical Cardiology and Personalized Medicine: Interrelated Concepts in Clinical Cardiology

Personalized medicine—a modern approach for the diagnosis and management of hypertension

Epstein - Barr virus Reactivation Associated with an Increased Thymidine Kinase and Normalized by an Immuno Modulatory Nano-Therapy: Three Case Reports

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