Conceptual Importance of Acidifiers, Antacids and Cathartics for its Significance in Pharmaceuticals-A Brief Review

Fatima, Juveriya; Khan, Saniya; Rasheed, Nuha; Mohammad, Abdul Saleem

doi:10.5958/2231-5713.2017.00009.5

Cited by 2 publications

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“…3,4 Antacids like Sodium bicarbonate, Sodium citrate, Magnesium hydroxide, Aluminum hydroxide, Aluminum phosphate are used in mild GERD to give symptomatic relief to patients. 5,6 Proton Pump Inhibitors (PPIs) are the first choice of drugs for treating GERD. Proton pump inhibitors include pantoprazole, omeprazole and ranaprazole.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Evaluation of Various Therapies of Synthetic Drugs with Amla and Honey Combination for the Treatment of Gastroesophageal Reflux Disease

Mazumder¹,

Kumar²,

Das³

2023

Ind. J. Pharm. Edu. Res.

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Background: Gastroesophageal Reflux Disease (GERD) is disorder of oesophagus that causes ulcer and erosion. Materials and Methods: A comparison based on the in vivo study was carried out to determine the therapeutic efficacy of herbal formulation using Amla and Honey in combination with Pantoprazole and Rebamipide for the treatment of GERD. The effects of all above mentioned medications were also checked on intestinal motility. In vitro studies were carried out to determine the antispasmodic activity of Amla and Honey in comparison to acetylcholine by isolated rat ileum. In pylorus ligation GERD model, mono-therapy was performed by giving herbal formulation of Amla and Honey. In combination therapy Pantoprazole and Rebamipide, Amla and Honey with Pantoprazole and Rebamipide were given and their therapeutic efficacy was observed at the ends of 14 days. In charcoal meal motility test the distance travelled by charcoal in intestine was measured. Results and Discussion: Combination therapy have highest therapeutic efficacy in comparison to mono-therapy of natural combination of Amla and Honey against Pantoprazole and Rebamipide. In vitro antispasmodic activity revealed that Amla and Honey formulation decreased the contractility pattern in concentration dependent manner against acetylcholine. In charcoal meal motility test highest intestinal motility were observed in Amla and Honey and can be given in GERD for easily digestion of food from stomach. Conclusion: Herbal combination of Amla and Honey in comparative evaluation decreases the Gastroesophageal reflux disease, intestinal mobility, and show anti-spasmodic activity in isolated rat's ileum. However, these combinations serve as a more potential agent for decreasing all the factors responsible for the reflux disease.

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Section: Introductionmentioning

confidence: 99%

A Comparative Evaluation of Various Therapies of Synthetic Drugs with Amla and Honey Combination for the Treatment of Gastroesophageal Reflux Disease

Mazumder¹,

Kumar²,

Das³

2023

Ind. J. Pharm. Edu. Res.

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A Comparative Study on Mono-therapy and Combination Therapy of Additive Drugs (Rebamipide and Pantoprazole) with Amla and Honey combination for the Treatment of Gastroesophageal Reflux Disease and Intestinal motility

Mazumder

Kumar

Das

et al. 2022

RJPT

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Gastroesophageal reflux disease (GERD) is digestive disorder of oesophagus. Reflux of food damage oesophagus and cause oesophageal ulcer and erosion. The treatment strategy starts by giving natural formulation and synthetic drugs. A comparison based on In-vivo study was carried out to determine the therapeutic efficacy of herbal formulation using Amla and Honey in combination with Pantoprazole and Rebamipide for the treatment of GERD, The effects of all above mentioned medication was also checked on intestinal motility. In vitro studies were carried out to determine the antispasmodic activity of Amla and Honey in comparison to acetylcholine by isolated rat ileum. In pylorus ligation GERD model mono-therapy was performed by giving herbal formulation of Amla and Honey. In combination therapy Pantoprazole and Rebamipide, Amla, Honey with Pantoprazole and Rebamipide were given and their therapeutic efficacy was observed at the ends of 14 days. In charcoal meal motility test the distance travelled by charcoal in intestine was measured. At the end of study it was concluded that combination therapy have highest therapeutic efficacy in comparison to mono-therapy of natural combination of Amla and Honey against Pantoprazole and Rebamipide. In In-vitro antispasmodic activity Amla and Honey formulation decreased the contractility pattern in concentration dependent manner against acetylcholine. In charcoal meal motility test highest intestinal motility were observed in Amla and Honey and can be given in GERD for easily digestion of food from stomach.

show abstract

Conceptual Importance of Acidifiers, Antacids and Cathartics for its Significance in Pharmaceuticals-A Brief Review

Cited by 2 publications

References 0 publications

A Comparative Evaluation of Various Therapies of Synthetic Drugs with Amla and Honey Combination for the Treatment of Gastroesophageal Reflux Disease

A Comparative Evaluation of Various Therapies of Synthetic Drugs with Amla and Honey Combination for the Treatment of Gastroesophageal Reflux Disease

A Comparative Study on Mono-therapy and Combination Therapy of Additive Drugs (Rebamipide and Pantoprazole) with Amla and Honey combination for the Treatment of Gastroesophageal Reflux Disease and Intestinal motility

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