Conceptual, Regulatory and Strategic Imperatives in the Early Days of EEG-Based Biomarker Validation for Neurodevelopmental Disabilities

Ewen, Joshua B.; Sweeney, John A.; Potter, William Z.

doi:10.3389/fnint.2019.00045

Cited by 59 publications

(58 citation statements)

References 71 publications

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“…Validating causal models is central to the mechanistic understanding that is fundamental to the scientific enterprise but is also practically important in predicting how putative treatments are likely to be effective or ineffective. Causal understanding is also critical for designing biomarkers that validly report on what they are understood to reflect (Ewen, Sweeney, & Potter, ).…”

Section: Discussionmentioning

confidence: 99%

Increased mirror overflow movements in ADHD are associated with altered EEG alpha/beta band desynchronization

McAuliffe

Hirabayashi

Adamek

et al. 2019

Eur J of Neuroscience

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Children with ADHD show developmentally abnormal levels of mirror overflowunintentional movements occurring symmetrically opposite of intentional movements. Because mirror overflow correlates with ADHD behavioral symptoms, the study of disinhibition in motor control may shed light on physiologic mechanisms underlying impaired behavioral/cognitive control. This is a case-controlled study of EEG recording from 25 children with ADHD and 25 typically developing (TD) controls performing unilateral sequential finger tapping, with overflow movements measured using electronic goniometers. Consistent with previously published findings, children with ADHD showed increased mirror overflow as compared with TD peers. EEG findings revealed less lateralized alpha modulation (event-related desynchronization; ERD) and decreased magnitude of beta ERD in ADHD; both alpha and beta ERD reflect cortical activation. Moderation analysis revealed a significant association between beta ERD and overflow, independent of diagnosis; and an equivocal (p = .08) effect of diagnosis on the relationship between alpha ERD and overflow, with a significant effect in children with ADHD but not TD children. These results suggest two mechanisms involved with mirror overflow: one reflected in beta ipsilateral to the intentional movement and relevant to both children with ADHD and controls, and the other seemingly more specific to ADHD (alpha, contralateral to movement). K E Y W O R D SEEG, moderation analysis, motor control, sensory-motor rhythm 1816 | MCAULIFFE Et AL.

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Section: Discussionmentioning

confidence: 99%

Increased mirror overflow movements in ADHD are associated with altered EEG alpha/beta band desynchronization

McAuliffe

Hirabayashi

Adamek

et al. 2019

Eur J of Neuroscience

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“…Recent studies showed measurement of markers to understand the complex systems [118][119][120]. The markers include neurotransmitters, hormones and markers of immune function and inflammation [121][122][123][124][125][126][127]. It has been suggested that OS may play a role in etiopathogenesis of ADS, that neurological changes may be due to OS occurring in early brain tissue development and reduced antioxidative barrier [128].…”

Section: Lpas In Subjects With Autismmentioning

confidence: 99%

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

et al. 2020

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In this review, applications of near-infrared photoacoustic spectroscopy are presented as an opportunity to evaluate human respiration because the measurement of breath is fast, intact and simple to implement. Recently, analytical methods for measuring biomarkers in exhaled air have been extensively developed. With laser-based photoacoustic spectroscopy, volatile organic compounds can be identified with high sensitivity, at a high rate, and with very good selectivity. The literature review has shown the applicability of near-infrared photoacoustic spectroscopy to one of the problems of the real world, i.e., human health. In addition, the review will consider and explore different breath sampling methods for human respiration analysis.

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“…A significant concern to interpretation of SNR measures in ASD is that these methods are sensitive to non-physiological noise, and individuals with ASD may have an increased magnitude of this artifact, including muscle and eye-blink artifact in MEG/EEG [110,111].…”

Section: Signal-to-noisementioning

confidence: 99%

Using Connectivity to Explain Autism

Adamek¹,

Luo²,

Ewen³

2019

Preprint

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The chapters in this Handbook reveal the breadth of brilliant imaging and analysis techniques designed to fulfill the mandate of cognitive neuroscience: to understand how anatomical structures and physiological processes in the brain cause typical and atypical behavior. Yet these techniques by themselves are insufficient; we also need a complementary, cognitive toolbox containing methods of inference that allow us to derive true scientific explanation from data. It is inherently challenging to establish a causal explanation from observational data, such as imaging data. In this chapter, we reverse engineer one of the most influential accounts of a neuropsychiatric disorder that is derived from imaging data: the connectivity theories of autism spectrum disorder (ASD). We take readers through our approach, which is first to consider all possible causal paths that are allowed by preliminary imaging-behavioral correlations. By progressively sharpening the specificity of the measures and brain/behavioral constructs, we iteratively chip away at this space of allowable causal paths, like the sculptor chipping away the excess marble from the previously-hidden statue. To assist in this process, we offer a novel set of connectivity constructs that can more specifically relate notions of information transmission in the mind to the physiology of the brain.

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Conceptual, Regulatory and Strategic Imperatives in the Early Days of EEG-Based Biomarker Validation for Neurodevelopmental Disabilities

Cited by 59 publications

References 71 publications

Increased mirror overflow movements in ADHD are associated with altered EEG alpha/beta band desynchronization

Increased mirror overflow movements in ADHD are associated with altered EEG alpha/beta band desynchronization

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

Using Connectivity to Explain Autism

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