Work Integration Social Enterprises (WISE) are a means of redressing injustices that People With Mental Illness and/or Intellectual Disability (PWMI/ID) face in the labor market. As the field’s understanding of WISE improves, many have argued for the need to study their underlying philosophies and ethical foundations. We present a case study of a WISE for PWMI/ID that responds to a humanistic-personalist framework. This framework is based on the consideration of several features of the person: their wholeness, uniqueness, intrinsic dignity, innate rights, and capacity for permanent development. Under this perspective, human work entails dignity because it is a potential source of meaning and personal growth. The humanistic-personalist framework is more comprehensive than other approaches presented in the literature, based on justice and human rights or care ethics, thereby advancing our knowledge of how WISE may provide economically viable and meaningful work experiences to underserved communities. Drawing from this humanistic-personalist perspective, we provide six criteria that can serve as a normative framework for organizations, particularly WISE for PWMI/ID. The case study focuses on La Fageda, a 40-year-old Spanish WISE that has achieved significant social and economic success. La Fageda is based on a sound understanding of the human person. From its foundations and practices, three pillars are identified: the rehabilitating power of work, the practice of designing individual itineraries, and the pursuit of economic success as a means to social success, which is the project’s mission.