Concerning the Mechanisms of Insulin Action: The Banting Memorial Lecture 1961

Levine, Rachmiel

doi:10.2337/diab.10.6.421

Cited by 25 publications

(5 citation statements)

References 9 publications

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“…Apparently as "a voice in the wilderness" urging attention to the importance of transport and its control, Rudolph Hober suggested in 1914, before insulin was known, that diabetes might well be a disease of sugar transport by the cell membrane (Levine, 1961). Lundsgaard showed in 1939 that insulin accelerated sugar uptake by perfused striated muscle.…”

Section: Insulinmentioning

confidence: 99%

“…Lundsgaard showed in 1939 that insulin accelerated sugar uptake by perfused striated muscle. Levine and his associates showed, beginning in 1949 (see also Levine, 1961), that insulin accelerates the entry of sugars into the cellular compartment as estimated for the whole organism. This action has since been confirmed specifically for a number of isolated tissues, including particularly the heart, the diaphragm, and the epididymal fat pad.…”

Section: Insulinmentioning

confidence: 99%

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Biological transport

Christensen¹

1962

100

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What a strange field is transport! Here the investigator gathers information from kidney tubules, tumor cells, frog skins, gut sacs, and toad bladders. With such as these he observes behavior that violates the intuition of the enzymologist, morphologist, and chemist, and observes the behavior of molecules that may have proved inert in his every other test. Biological transport is by no means a new subject, but it is one that has gained tremendously in interest from the various biological sciences in the last few years. The subject evolved from two rather discrete interests-that of permeability phenomena, extending back more than 60 years, and that of problems of secretion. The difficulties posed by the latter were found in the late 1930s to be associated with the former. With the closer approach to the interpretation of other cellular phenomena, the need to understand how substances and reactions are segregated and brought together in the cell and in the organism has become so pressing that many ingenious, indirect approaches to these questions have been discovered. Meanwhile, the search for the means to identify directly the structures producing transport has continued. This presentation grew from a short series of lectures to an advanced biochemistry class, attended also by graduate students of pharmacology, physiology, microbiology, genetics, and other sciences. It should be interpreted more as a bibliographed syllabus for that instruction than as a review. Accordingly, the author has PREFACE selected the illustrative material and examples that seemed most suitable and familiar to him. The result can hardly seem to have the ideal balance to all the scientific areas now interested in transport. Perhaps physiologists and pharmacologists would like to read more about the intricacies of ion transport, the physical and mathematical biologists more of the theoretical background, the cytolooists more about the morphological substratum, and so on. Although all divergent needs cannot be met, I trust this summary will prove useful to both teaching and learning in various disciplines.

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Section: Insulinmentioning

confidence: 99%

Section: Insulinmentioning

confidence: 99%

Biological transport

Christensen¹

1962

100

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“…According to Levine (20), glucose stimulates insulin secretion and by this galactose is carried into the muscle cells together with glucose. Levine (20) was able, on the other hand, to show that later galactose returns into the extracellular space, which is to prove that the initial intracellular entry o f galactose does not mean an intracellular metabolization.…”

Section: Galactosementioning

confidence: 99%

Quantitative Comparison and Evaluation of Utilization of Parenteral Administered Carbohydrates

Heuckenkamp¹,

Zöllner²

1975

Ann Nutr Metab

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“…Die Aktivierung der Lipolyse unterliegt hormonalen Einflüssen. Im Gegensatz zum Blutzucker, dessen periphere Utilisation innerhalb eines relativ großen Konzentrationsbereiches an die Anwesenheit von Insulin gebunden ist (47), erfolgt der Abbau der unveresterten Fettsäuren ohne hormonale Kontrolle. Ihre Utilisation hängt ausschließlich von der Höhe ihrer Blutkonzentration ab (2,33).…”

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Über die Regulation der unveresterten Fettsäuren - unter besonderer Berücksichtigung der Prostaglandine^*

Böhle¹,

Ditschuneit²,

Melani³

et al. 1966

Dtsch med Wochenschr

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Böhle u. a.: tJber die Regulation der unveresterten Fettsäuren 1083 Das Interesse, das seit einigen Jahren dem Stoffwechsel des Fettgewebes entgegengebracht wird, geht auf die Erkenntnis zurück, daß die sogenannten unveresterten Fettsäuren des Blutes, die im wesentlichen aus dem Speicherfett stammen, eine wichtige Transportform der Lipide von den Depots zu den Orten des Verbrauchs darstellen. Als Brennstoff für die Lebensvorgänge kommt den unveresterten Fettsäuren die gleiche Aufgabe zu wie dem Blutzucker. Dementsprechend bestehen auch zwischen dem Umsatz der unveresterten Fettsäuren und der Glucose enge Wechselbeziehungen. Das Fettgewebe steht im Zentrum dieses Systems. Hier werden überschüssige Energievorräte aus dem Fettund Kohlenhydratstoffwechsel als Triglyceride gespeichert und diese Reserven in Abhängigkeit von den energetischen Bedürfnissen in Gestalt der unverestertenFettsäurenwieder mobilisiert. Die metabolischen Vorgänge im Fettgewebe haben in der letzten Zeit besondere Beachtung gefunden, weil Störungen der regulatorischen Einflüsse auf dieses System bei verschiedenen Krankheiten, zum Beispiel beim Diabetes mellitus und bei der Fettsucht, in Erscheinung treten können.Unter den Stoffwechselvorgängen im Fettgewebe kommt der Lipolyse, das heißt der Freisetzung von unveresterten Fettsäuren, große Bédeutung zu. Schwankungen des Gehaltes an unveresterten Fett-

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Concerning the Mechanisms of Insulin Action: The Banting Memorial Lecture 1961

Cited by 25 publications

References 9 publications

Biological transport

Biological transport

Quantitative Comparison and Evaluation of Utilization of Parenteral Administered Carbohydrates

Über die Regulation der unveresterten Fettsäuren - unter besonderer Berücksichtigung der Prostaglandine^*

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Concerning the Mechanisms of Insulin Action: The Banting Memorial Lecture 1961

Cited by 25 publications

References 9 publications

Biological transport

Biological transport

Quantitative Comparison and Evaluation of Utilization of Parenteral Administered Carbohydrates

Über die Regulation der unveresterten Fettsäuren - unter besonderer Berücksichtigung der Prostaglandine*

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Product

Resources

About

Über die Regulation der unveresterten Fettsäuren - unter besonderer Berücksichtigung der Prostaglandine^*