Concerning the Validity of Gastrointestinal Extracellular Recordings

O’Grady, Gregory; Angeli, Timothy R.; Du, Peng; Cheng, Leo K.

doi:10.1152/physrev.00005.2015

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Direct activation of SMCs with optogenetics can directly induce contractile activity in the stomach [ 70 ]. There is controversy regarding the validity of extracellular recording [ 71 , 72 ]. Isolated cells are not fully representative of the condition in the physiological state, so in vivo techniques are needed.…”

Section: Ion Channels Modulating Gastrointestinal Motilitymentioning

confidence: 99%

Role of Ion Channels in the Chemotransduction and Mechanotransduction in Digestive Function and Feeding Behavior

Zhu

Liu

et al. 2022

IJMS

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The gastrointestinal tract constantly communicates with the environment, receiving and processing a wide range of information. The contents of the gastrointestinal tract and the gastrointestinal tract generate mechanical and chemical signals, which are essential for regulating digestive function and feeding behavior. There are many receptors here that sense intestinal contents, including nutrients, microbes, hormones, and small molecule compounds. In signal transduction, ion channels are indispensable as an essential component that can generate intracellular ionic changes or electrical signals. Ion channels generate electrical activity in numerous neurons and, more importantly, alter the action of non-neurons simply and effectively, and also affect satiety, molecular secretion, intestinal secretion, and motility through mechanisms of peripheral sensation, signaling, and altered cellular function. In this review, we focus on the identity of ion channels in chemosensing and mechanosensing in the gastrointestinal tract.

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Section: Ion Channels Modulating Gastrointestinal Motilitymentioning

confidence: 99%

Role of Ion Channels in the Chemotransduction and Mechanotransduction in Digestive Function and Feeding Behavior

Zhu

Liu

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…[2][3][4][5][6] It is important to present a balanced factual assessment on the validity of extracellular recordings, so that readers and reviewers remain correctly informed about the technique. In the study cited by Worth et al, 1 slow waves could not be recorded in vitro using extracellular electrodes.…”

Section: To the Editormentioning

confidence: 99%

“…However, failing to record slow waves in one study does not mean they cannot be recorded generally. The claims in this study have been discredited for well-documented reasons, [2][3][4][5] including extensive use of in-correct filters. 6 In addition, extracellular recordings are more challenging in vitro, as coherent propagating wavefronts are required, and frequency gradients can be disturbed in isolated preparations.…”

Section: To the Editormentioning

confidence: 99%