Concerns about the feasibility of using “precision guided sterile males” to control insects

Bouyer, Jérémy; Vreysen, Marc J. B.

doi:10.1038/s41467-019-11616-9

Cited by 11 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…albopictus males 18,24 and transgenic sterile Ae. aegypti males 25,26 performed better in semi-field condition than in the field 27 . In this study, the discrepancy in male performance between field and semifield conditions could be attributed to several factors including variations in eco-climatic parameters as well as potential differences in morphological size 28,29,30 35 and that in many flying insects, wind has a significant impact on their flight ability as well as on their emission and responsiveness to sex pheromones 36,37,38,39,40,41,42,43,44 .…”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Pilot Suppression trial ofAedes albopictusmosquitoes through an Integrated Vector Management strategy including the Sterile Insect Technique in Mauritius

Iyaloo

Bouyer²,

Facknath

et al. 2020

Preprint

View full text Add to dashboard Cite

It is often difficult to control the vector mosquito Aedes albopictus using conventional chemical control methods alone at an operational level mainly because of (1) the ability of the species to lay eggs in a variety of places which are often difficult to detect or access by larviciding operators, (2) the inherent tendency of adults to live and feed outdoor which makes them unlikely targets of Insecticide Residual Spraying and (3) the development of resistance to insecticides by the species. It is therefore necessary for countries to investigate alternative control methods (such as the Sterile Insect Technique (SIT)) that can be integrated in their national vector control programme in order to address those limitations.

show abstract

Section: Discussionmentioning

confidence: 84%

“…albopictus mosquitoes. Overall, a field competitiveness of 0.40 can still be considered as a good result in comparison to other published trials based on transgenic mosquitoes32 . It was however slightly lower than the 0.5-0.7 values obtained recently in China in a successful suppression effort of Ae.…”

mentioning

confidence: 72%

Pilot Suppression trial ofAedes albopictusmosquitoes through an Integrated Vector Management strategy including the Sterile Insect Technique in Mauritius

Iyaloo

Bouyer²,

Facknath

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Finally, notwithstanding its inherently safe nature, pgSIT requires genetic modification, and regulatory use authorizations will need to be granted prior to implementation. While this could be viewed as a limitation ( 21 ), we don’t expect obtaining such authorizations to be insurmountable. In fact, we envision pgSIT to be regulated in a similar manner to Oxitec’s RIDL technology, which has been successfully deployed in many locations and recently received experimental use authorizations in the USA.…”

Section: Discussionmentioning

confidence: 98%

“…For pgSIT to be realized in the wild, the two strains will first need to be separately and continuously mass-reared in a facility, without contamination, and crossed to produce sterile ♂’s. While this can be viewed as rate-limiting ( 21 ), it offers stability, as the binary CRISPR system will remain inactive until crossed—thereby reducing the evolution of suppressors or mutations that could disrupt the system. Additionally, each sorted ♀can produce up to 450 eggs in her lifetime ( 22 ), which improves scalability.…”

Section: Discussionmentioning

confidence: 99%

Eliminating Mosquitoes with Precision Guided Sterile Males

Yang

Bui

et al. 2021

Preprint

View full text Add to dashboard Cite

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and zika, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic control system termed precision guided sterile insect technique (pgSIT) in Aedes aegypti. PgSIT uses a simple CRISPR-based approach to generate sterile males that are deployable at any life stage. Supported by mathematical models, we empirically demonstrate that released pgSIT males can compete, suppress, and eliminate mosquitoes in multigenerational population cages. This platform technology could be used in the field, and adapted to many vectors, for controlling wild populations to curtail disease in a safe, confinable, and reversible manner.

show abstract

“…However, this approach would require another perfect sexing method in the starting generation to sort males and females to establish the correct cross. Moreover, the researchers propose to release eggs so that the female larvae compete for food in density-dependent species but it is hardly possible in Aedes mosquitoes that have multiple small breeding sites, and such strains cannot be used for pests whose larvae damage crops [74].…”

Section: Conditional Female Death In Late Developmental Stagesmentioning

confidence: 99%

Sex Sorting for Pest Control: It’s Raining Men!

Lutrat

Giesbrecht

Marois

et al. 2019

Trends in Parasitology

Self Cite

View full text Add to dashboard Cite

In the pursuit of better pest-and vector-control strategies, attention returns to an old proven technology, the sterile insect technique (SIT) and related insect population-suppression methods. A major obstacle for any of these approaches that involves the release of sterile males is the separation of males from females during the mass rearing stage, in order to improve the cost-efficiency of these methods and to prevent the release of biting and disease-vectoring females. This review describes recent sex-sorting developments in dipteran flies with an emphasis on assessing the suitability of these methods for large-scale rearing of male vectors for mass release. Sexing Is an Obstacle in Genetic Pest-control ProgramsHighlights Sexing Diptera represents a major obstacle to operationalizing vector-control methods based on the mass release of males, such as the sterile insect technique or the incompatible insect technique.

show abstract

Concerns about the feasibility of using “precision guided sterile males” to control insects

Cited by 11 publications

References 12 publications

Pilot Suppression trial ofAedes albopictusmosquitoes through an Integrated Vector Management strategy including the Sterile Insect Technique in Mauritius

Pilot Suppression trial ofAedes albopictusmosquitoes through an Integrated Vector Management strategy including the Sterile Insect Technique in Mauritius

Eliminating Mosquitoes with Precision Guided Sterile Males

Sex Sorting for Pest Control: It’s Raining Men!

Contact Info

Product

Resources

About