Concerns related to ED-mediated effects of Bisphenol A and their regulatory consideration

Pouzaud, François; Thierry-Mieg, Morgane; Burga, Karen; Verines-Jouin, Lauranne; Fiore, Karine; Beausoleil, Claire; Michel, Cécile; Rousselle, Christophe; Pasquier, Elodie

doi:10.1016/j.mce.2018.02.002

Cited by 28 publications

(13 citation statements)

References 115 publications

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“…Some of these environmental factors are endocrine disruptors (EDCs) [ 2 ]. EDCs are widely distributed in our environment, and bisphenol A in plastics, its chlorinated derivatives in tap water and parabens in personal care products are some known examples [ 3 , 4 , 5 ]. Due to the transplacental transfer of these molecules, fetuses and children are particularly vulnerable [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Determinants of Risk Perception Related to Exposure to Endocrine Disruptors during Pregnancy: A Qualitative and Quantitative Study on French Women

Rouillon

Ouazzani

Rabouan

et al. 2018

IJERPH

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Endocrine disruptors (EDCs) are known as environmental exposure factors. However, they are rarely reported by health professionals in clinical practice, particularly during pregnancy, even though they are associated with many deleterious consequences. The objectives of this study were to estimate the risk perception of pregnant women related to EDC exposure and to evaluate its determinants. A qualitative study based on the Health Belief Model was carried out through interviews of pregnant women and focus group with perinatal, environmental health and prevention professionals in 2015 in the city of Poitiers, France. Then, determinants of risk perception were included in a questionnaire administered to 300 women in the perinatal period through a quantitative study. Scores were subsequently calculated. Perception of EDC risk was defined as perceived severity for different stages of the infant’s development and perceived susceptibility to EDC exposure. The determinants reported in the qualitative study were: age, strong maternal figure, socio-professional category, level of knowledge, and involuntariness of exposure. Age and level of knowledge were confirmed in our statistical model as determinants. Mean score of EDC risk perception was 55.0 ± 18.3 on 100 points. Our study should guide healthcare providers when advising pregnant women about EDC and environmental exposure. Our score for perceived EDC risk and assessment of its known determinants may help to assess the impact and the relevance of prevention programs dedicated to reducing exposure to EDC during pregnancy.

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Section: Introductionmentioning

confidence: 99%

Determinants of Risk Perception Related to Exposure to Endocrine Disruptors during Pregnancy: A Qualitative and Quantitative Study on French Women

Rouillon

Ouazzani

Rabouan

et al. 2018

IJERPH

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“…Under the European regulation of chemicals REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), substances having ED properties have to be identified as Substances of Very High Concern (SVHC) as first step towards regulation and appropriate risk management. The use of SVHC is controlled by temporary authorisations conditioning its uses and strongly encouraging its substitution (European Union, 2006;Beausoleil et al, 2018). Although REACH regulation does not provide any specific ED criteria, the European Commission last communication on EDs claimed the development of a horizontal approach for ED identification across EU legislation built on the pesticides criteria (EC Communication, 2018).…”

Section: Selection Of the Model Substancementioning

confidence: 99%

“…Accordingly, an ED substance has to show (i) endocrine adverse health effects in individuals and/or their offspring, (ii) endocrine activity through an endocrine mode of action (MoA) and (iii) a plausible and clear-established link between the adverse effects and the endocrine MoA (Munn and Goumenou, 2013). However, to demonstrate that a given substance is an ED represents a huge challenge due to the complex and critical roles of the endocrine system in maintaining the homeostasis of all biological processes, as well as the multiple pathways and mechanisms involved (Beausoleil et al, 2018). Scientific criteria to identify substances with ED properties have been recently implemented in plant protection products (PPP) regulation (European Union, 2009), and biocidal products (BP) regulation (European Union, 2012) applying from June 2018 and November 2018, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…The hormone system has an essential role in the regulation of many physiological functions such as body development, growth, reproduction, metabolism, immunity, inflammation and behaviour (Chrousos, ). Endocrine disruptors (EDs) are exogenous compounds that interfere with any aspect of endogenous hormone system, including hormones production, release, transport, metabolism, binding, action or elimination, negatively affecting human health (Lee, ; Pouzaud et al., ). They represent a special and challenging form of toxicity as their effects depend on both the level and timing of exposure, being especially critical in developmental stages (WHO/UNEP, ).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the endocrine disrupting properties of Bisphenol AF according to the EU criteria and ECHA/EFSA guidance

Escrivá¹,

Hanberg²,

Zilliacus³

et al. 2019

EFS2

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Endocrine disruptors (EDs) are exogenous compounds that interfere with the hormone system, affecting human health and environment. Specific legislative obligations have been introduced in the European Union (EU) to gradually eliminate EDs in water, industrial chemicals and pesticides. However, identification of EDs is the first and essential step towards regulation and appropriate risk management. Scientific criteria and guidance for ED assessment have recently been established for pesticides in the EU. In this project, the ED properties of the non‐pesticide chemical Bisphenol AF (BPAF), analogue and potential substitute of Bisphenol A were evaluated by the application of the EU criteria and guidance in the frame of human health risk assessment. A data dossier was built by a systematic literature review (WOS, Scopus, Pubmed, Embase), title/abstract screening (RAYYAN) and full‐text examination. All relevant information was extracted and systematically reported, and reliability and relevance of data were assessed (SciRAP). Data were synthesised into lines of evidence for (i) endocrine activity, (ii) adversity and (iii) general toxicity, and weight of evidence evaluation was applied. The initial analysis of the evidence showed potential endocrine adverse effects and endocrine activity, meeting the ED criteria and leading the assessment to the mode of action (MoA) analysis. The biological plausibility of the link between the adverse effects and the endocrine activity was investigated based on current scientific knowledge. Empirical support for dose–response and temporal concordance was evaluated, and the key events were assessed in terms of essentiality, consistency, analogy and specificity. Finally, an overall conclusion of the ED properties of BPAF was drawn. The EU criteria and guidance for EDs assessment were successfully applied to BPAF demonstrating its endocrine activity and adversity based on weight of evidence methodology and MoA analysis. The Fellow greatly increased her knowledge and hands‐on experience on ED assessment in the EU regulatory context contributing to implement transparency and structure in health risk assessment.

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“…Entre los bisfenoles, uno de los compuestos más usados como monómero del policarbonato es el compuesto bisfenol A (BPA, 4,4'-isopropilidendifenol), una de las sustancias químicas con mayor volumen de producción, que se emplea también en la fabricación de las resinas epoxi, utilizadas para los revestimientos internos de latas de alimentos y bebidas, entre otros usos. El BPA es una sustancia química, disruptora endocrina (EDC), bien conocida por su capacidad de unirse a receptores hormonales, como por ejemplo el receptor de estrógeno nuclear (ER) (Wetherill et al, 2007;Pouzaud et al, 2018), lo que le permite modificar su expresión génica (Chianese et al, 2018); aunque también puede unirse a otras familias de receptores de membrana (Alonso-Magdalena et al, 2012), e incluso inducir actividades anti-androgénicas in vitro (Molina-Molina et al, 2013).…”

Section: Introductionunclassified

Implicaciones de la exposición a microplásticos en salud humana. Revisión bibliográfica

Fimia¹

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Concerns related to ED-mediated effects of Bisphenol A and their regulatory consideration

Cited by 28 publications

References 115 publications

Determinants of Risk Perception Related to Exposure to Endocrine Disruptors during Pregnancy: A Qualitative and Quantitative Study on French Women

Determinants of Risk Perception Related to Exposure to Endocrine Disruptors during Pregnancy: A Qualitative and Quantitative Study on French Women

Assessment of the endocrine disrupting properties of Bisphenol AF according to the EU criteria and ECHA/EFSA guidance

Implicaciones de la exposición a microplásticos en salud humana. Revisión bibliográfica

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