Concise synthesis of (25S)-Δ⁴-dafachronic acid and desulfated boophiline enabled by photoinduced decarboxylative allylation and asymmetric hydrogenation

Abstract

(25S)-Δ4-Dafachronic acid and boophiline exhibit intriguing bioactivities. However, the C-25 configuration of boophiline remains undetermined. Here, we present a concise synthesis of them from readily available bile acids. The synthesis...