Concluding Remarks

Comparison of Insulin With or Without Continuation of Oral Hypoglycemic Agents in the Treatment of Secondary Failure in NIDDM Patients

“…For the combination group, OHA therapy was not changed and supplementary insulin was added at a small arbitrary dose of 6 U given 30 min before retiring or by 11:00 P.M. (9). The dose was adjusted every 1-2 weeks using increments of 2-4 U.…”

“…This leads to a need for exogenous insulin therapy. Because this is a gradual process, combined therapy that continues OHA therapy together with the smallest possible insulin dose may be a logical treatment regimen at the intermediate stage while some response to OHAs is still present (7,9). Over the last decade, numerous trials of such combination therapy have been conducted, but available results are conflicting (4,(18)(19)(20) and firm conclusions difficult to draw.…”