Conclusions of the French Food Safety Agency on the toxicity of bisphenol A

Arnich, Nathalie; Canivenc-Lavier, Marie-Chantal; Kolf‐Clauw, Martine; Coffigny, Hervé; Cravedi, Jean‐Pierre; Grob, Konrad; Macherey, Anne-Christine; Masset, Dominique; Maximilien, Rémy; Narbonne, Jean‐François; Nesslany, Fabrice; Stadler, Jeanne; Tulliez, Jacques

doi:10.1016/j.ijheh.2010.12.002

Cited by 34 publications

(26 citation statements)

References 23 publications

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“…1,2 In the earlier study, residual amounts of BPA found in polycarbonate food contact articles ranged from 7 to 58 μg/g. 3 The European Commission established a migration limit of 600 μg/kg for BPA in plastic products that are intended for food-contact applications.…”

Section: ■ Introductionmentioning

confidence: 93%

Effects of Bisphenol S on the Structures and Activities of Trypsin and Pepsin

Wang

Zhang

2014

J. Agric. Food Chem.

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The effects of bisphenol S on the structures and activities of trypsin and pepsin were investigated by various methods like UV-visible absorbance, fluorescence, circular dichroism, and molecular docking. The secondary and tertiary structures of trypsin and pepsin were altered by bisphenol S binding, which resulted in the loosening of the skeletons of trypsin and pepsin. In addition, bisphenol S induced microenvironmental changes around tyrosine and tryptophan residues of trypsin and pepsin. The activity experimental results showed that the activity of pepsin decreases obviously with the increasing concentration of BPS, while the activity of trypsin does not change remarkably. The binding and thermodynamic parameters obtained by molecular docking and fluorescence spectroscopy showed that the bindings of bisphenol S to trypsin and pepsin were spontaneous processes and hydrogen bonding and hydrophobic interactions played a vital role in stabilizing the bisphenol S-trypsin and bisphenol S-pepsin complexes. The binding constants (K(A)) of bisphenol S with trypsin were 7.42 × 10(4) (298 K) and 5.91 × 10(4) L/mol (310 K), and those of pepsin were 5.78 × 10(4) (298 K) and 4.44 × 10(4) L/mol (310 K). Moreover, there was one main kind of binding site for bisphenol S on trypsin or pepsin.

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Section: ■ Introductionmentioning

confidence: 93%

Effects of Bisphenol S on the Structures and Activities of Trypsin and Pepsin

Wang

Zhang

2014

J. Agric. Food Chem.

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“…Traditionally, one of the most commonly used coatings are epoxy-resins based in part on bisphenol A (BPA). BPA is a monomer that has been receiving much attention because of its possible effect as endocrine disruptor at lower doses [1,2]. However, recently, two independents agencies, such as Food and Drug Administration (FDA) and European Food Safety Authority (EFSA) independently reached the same conclusion, that BPA poses no health risk to consumers at the exposure concentrations in food [3] [4].In spite of these conclusions, consumers remain wary about the use of BPA in food contact materials.…”

Section: Introductionmentioning

confidence: 99%

Identification of unknown compounds from polyester cans coatings that may potentially migrate into food or food simulants

Paseiro-Cerrato

MacMahon

Ridge

et al. 2016

Journal of Chromatography A

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Cross-linked polyester resins are being introduced into the market as alternatives to epoxy resins as coatings for metal food cans. Identification of potential migrants, from these coatings into food, is a significant analytical challenge due to the diversity of substances employed in the manufacture of the coatings. However, such identification is required to assess migration from the can coating into the food and quantify dietary exposure. Polyester can coatings were extracted with acetonitrile at 40°C for 24h and the extracts were analyzed by a variety of analytical techniques, including GC-MS, HPLC-DAD/MS, HPLC-DAD/CAD and UHPL C-HRMS. Twenty nine non-volatile oligomers were tentatively identified using retention times, UV spectra, and accurate mass measurements. Identified oligomers suggest the coating in use for food cans is a polyester coating and is mainly based on the monomers isophthalic acid, terephthalic acid and nadic acid. To give confidence in the identification, one of the tentatively identified oligomer was synthetized and analyzed by (13)C and (1)H NMR and UHPL C-HRMS. The NMR and HRMS results, confirmed the presence of this compound in the can extracts. Finally, to determine if rapid, direct detection of the oligomers was practical, the coatings were analyzed by DART-HRMS. Twenty three out of the 29 oligomers were identified in the coating by direct measurement with DART-HRMS in few minutes.

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“…The toxicological profile of BPA was described in several reports of EFSA (2006EFSA ( , 2010, USA National Toxicology Program (NTP-CERHR, 2008), FAO/WHO (2010), ANSES (2011) and in several reviews (Arnich et al, 2011;Hengstler et al, 2011). EFSA opinions issued focused on the oral route of exposure, because it was found to be the most relevant for risk assessment of food/feed.…”

Section: Existing Assessmentsmentioning

confidence: 99%

The safety of the use of bisphenol A in medical devices

Testai

Hartemann

Rodrı́guez-Farré

et al. 2016

Regulatory Toxicology and Pharmacology

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About the Scientific Committees Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health and Environmental Risks (SCHER) and the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCENIHR This Committee deals with questions related to emerging or newly identified health and environmental risks and to broad, complex or multidisciplinary issues requiring a comprehensive assessment of risks to consumer safety or public health and related issues not covered by other Community risk assessment bodies. Examples of potential areas of activity include potential risks associated with interaction of risk factors, synergic effects, cumulative effects, antimicrobial resistance, new technologies such as nanotechnologies, medical devices including those incorporating substances of animal and/or human origin, tissue engineering, blood products, fertility reduction, cancer of endocrine organs, physical hazards such as noise and electromagnetic fields (from mobile phones, transmitters and electronically controlled home environments), and methodologies for assessing new risks. It may also be invited to address risks related to public health determinants and non-transmissible diseases.

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Conclusions of the French Food Safety Agency on the toxicity of bisphenol A

Cited by 34 publications

References 23 publications

Effects of Bisphenol S on the Structures and Activities of Trypsin and Pepsin

Effects of Bisphenol S on the Structures and Activities of Trypsin and Pepsin

Identification of unknown compounds from polyester cans coatings that may potentially migrate into food or food simulants

The safety of the use of bisphenol A in medical devices

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