Concomitant cutaneous squamous cell carcinoma and chronic lymphocytic leukemia in a patient: The utility of <sup>18</sup>F‐FDG PET/CT in differentiation of nodal metastasis

Öztürk, Kerem; Üstün, Celalettin; Zhan, Kevin Y.; Li, Faqian; Rischall, Matthew; Cayci, Zuzan

doi:10.1002/ajh.25041

Cited by 2 publications

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“…No systematic study was done to investigate the rationality of not performing lymphadenectomy on patients with CLL and a secondary tumor. Ozturk K et al [14] reported a case with concomitant cutaneous squamous cell carcinoma and CLL and found two lymph nodes were positive for squamous cell carcinoma metastases among 25 lymph nodes involved by CLL. Tomaszewski JM et al [15] showed 31 out of 273 lymph nodes involved in CLL were infiltrated by squamous cell carcinoma cells in five cases of concomitant cutaneous squamous cell carcinoma and CLL.…”

Section: Discussionmentioning

confidence: 99%

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Extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia may not be necessary: a report of two cases

et al. 2019

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Background Chronic lymphocytic leukemia is a malignancy with good prognosis. However, the incidence of secondary tumors increases every year after the diagnosis of chronic lymphotcytic leukemia. One of the induced secondary tumors is prostate cancer. For high-risk prostate cancer in particular, the standard therapy is radical prostatectomy and extended lymphadenectomy, which carries high risks of lymphatic leakage and reduced quality of life. Currently, there has been no study reporting the necessity of extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia. Case presentation We reported two cases with concomitant high-risk prostate cancer and chronic lymphocytic leukemia. The first patient was a 60-year-old male diagnosed with synchronous prostate cancer and chronic lymphocytic leukemia. The second patient was a 70-year-old male initially presented with chronic lymphocytic leukemia alone but was then diagnosed with high-risk prostate cancer nine years later. Both patients received neoadjuvant androgen deprivation therapy and robot-assisted radical prostatectomy. The first patient underwent extended lymphadenectomy and developed prolonged postoperative lymphatic cyst. Histology showed chronic lymphocytic leukemia infiltration in resected lymph nodes. Serum prostate-specific antigen levels at one and 13 months post-operation were both 0.01 ng/ml. The second patient received positron emission tomography/computed tomography before androgen deprivation therapy, which showed mild fluorodeoxyglucose-avidity in lymph nodes across the entire body. Lymph node biopsy showed only chronic lymphocytic leukemia. The patient experienced no postoperative complication. Serum prostate-specific antigen levels at one and nine months post-operation were both 0.02 ng/ml. Conclusions Extended lymphadenectomy may not be necessary for patients with concomitant high-risk prostate cancer and chronic lymphocytic leukemia, but such patients must undergo thorough preoperative assessment and mindful postoperative follow-up. Positron emission tomography/computed tomography may be valuable in detecting nodal metastases. A lymph node biopsy is necessary for patients with an ambiguous positron emission tomography/computed tomography in the metastatic involvement of lymph node.

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Section: Discussionmentioning

confidence: 99%

“…Thus, it is important to investigate how to determine whether to undergo lymphadenectomy and the range of lymphadenectomy. It was reported that PET/CT was valuable for nodal staging [14, 15]. The SUVmax was > 10 for the lymph nodes with tumor metastases, whereas the SUVmax was ≤2.5 for the lymph nodes with CLL.…”

Section: Discussionmentioning

confidence: 99%

Extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia may not be necessary: a report of two cases

et al. 2019

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Setting the stage: Contemporary staging of non-melanomatous skin cancer and implementation of the new American Joint Committee on cancer eighth edition staging manual

et al. 2019

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Concomitant cutaneous squamous cell carcinoma and chronic lymphocytic leukemia in a patient: The utility of ¹⁸F‐FDG PET/CT in differentiation of nodal metastasis

Cited by 2 publications

References 4 publications

Extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia may not be necessary: a report of two cases

Extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia may not be necessary: a report of two cases

Setting the stage: Contemporary staging of non-melanomatous skin cancer and implementation of the new American Joint Committee on cancer eighth edition staging manual

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Concomitant cutaneous squamous cell carcinoma and chronic lymphocytic leukemia in a patient: The utility of 18F‐FDG PET/CT in differentiation of nodal metastasis

Cited by 2 publications

References 4 publications

Extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia may not be necessary: a report of two cases

Extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia may not be necessary: a report of two cases

Setting the stage: Contemporary staging of non-melanomatous skin cancer and implementation of the new American Joint Committee on cancer eighth edition staging manual

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Concomitant cutaneous squamous cell carcinoma and chronic lymphocytic leukemia in a patient: The utility of ¹⁸F‐FDG PET/CT in differentiation of nodal metastasis