Concomitant endometrial and cervical adenocarcinoma

Abstract

Rationale:Concomitant malignancy of the endometrium and cervix is extremely rare.Patient concerns:A 56-year-old female presented to the Women's Hospital, School of Medicine, Zhejiang University, complaining of irregular vaginal bleeding. The human papillomavirus test (type 18/45) was positive. We performed dilation and curettage; pathology revealed moderately differentiated endometrial carcinoma exhibiting squamous differentiation. The epithelium of the cervical uterus was atypical upon biopsy.Diagnoses:Histological and immunochemical tests confirmed a diagnosis of endometrial carcinoma concomitant with cervical adenocarcinoma.Interventions:She underwent laparoscopic staging surgery.Outcomes:The patient fully recovered with only surgery.Lessons:Endometrial carcinoma concomitant with cervical adenocarcinoma is very rare. It is imperative to schedule adequate examination, and to perform careful preoperative diagnosis and appropriate treatment to minimize relapse.

Synchronous Primary Carcinoma of Uterine Cervix and Endometrium - Single-center retrospective study

“…squamous and adenocarcinoma) [9]. Synchronous EC and CC are extremely rarely described in the literature and there are only several case reports published [10]. In our series the most common histology of EC was endometroid adenocarcinoma, whereas in the cervix -it was squamous cell carcinoma and these concur with data from large pathological studies.…”

Papillary Endometrial Adenocarcinoma with Cervical Dysplasia: Report of a Case and Review of Literature

“…Estrogen receptor (ER), progesterone receptor (PR), and vimentin were positive in endometrial sample with the opposite results in cervix. P16 was partially positive in endometrium but diffuse in cervical tumor [10]. Satyajeet Rath and the colleagues reported a 50 year-old lady with well differentiated adenocarcinoma of cervix and primary adenocarcinoma of ovaries.…”