Concomitant lysine and phosphorus addition to a wheat gluten protein diet highly amplified growth measures of rats

Ragi, Marie-Elizabeth; Mallah, Carla El; Toufeili, Imad; Obeid, Omar

doi:10.1016/j.nut.2018.11.009

Cited by 5 publications

(9 citation statements)

References 46 publications

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“…(2017) observed that feeding a low-protein diet (10% vs. a control diet at 20%) to rats significantly retarded growth but that these deleterious effects could be largely offset by increasing dietary phosphorus content, both in growth rate and also in body composition. Similar effects have been reported more recently where addition of lysine and P to a low protein diet in rats generated significant synergistic effects on growth rate ( Ragi et al., 2019 ). Putatively, if P supply is marginal then adenosine triphosphate ( ATP ) synthesis may be inadequate ( Hettleman et al., 1983 ) to support protein synthesis and growth and this may restrict feed intake to prevent circulatory accumulation of amino acids that can result in toxicity.…”

Section: Introductionsupporting

confidence: 85%

“…(2019) noted that the addition of available P to a low-protein diet for rats resulted in a decrease in plasma urea nitrogen, HDL cholesterol and triglycerides. In the results presented herein ( Table 9 ), there was no effect of available P on triglycerides although there was a reduction, congruent with Ragi et al. (2019) , of ammonia, uric acid, and HDL associated with increased available P. It is possible therefore that increased available P reduced protein catabolism, perhaps by providing adequate P for ATP synthesis and protein accretion.…”

Section: Discussionsupporting

confidence: 55%

“…Beneficial effects of additional available P in diets with marginal protein supply for rats has been presented by Hammoud et al. (2017) and Ragi et al. (2019) who noted that available P improved growth rate and had a range of post-prandial effects associated with elevated protein accretion.…”

Section: Discussionmentioning

confidence: 99%

“…(2019) who noted that available P improved growth rate and had a range of post-prandial effects associated with elevated protein accretion. Ragi et al. (2019) noted that the addition of available P to a low-protein diet for rats resulted in a decrease in plasma urea nitrogen, HDL cholesterol and triglycerides.…”

Section: Discussionmentioning

confidence: 99%

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Possible role of available phosphorus in potentiating the use of low-protein diets for broiler chicken production

Cowieson

Perez-Maldonado²,

Kumar

et al. 2020

Poultry Science

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A total of 945 male Ross 308 broiler chicks were used in a growth study to explore the interaction between dietary crude protein concentration and available phosphorus. Nine experimental treatments were constructed factorially by offering low, medium, or standard protein concentrations without or with low, standard, or high available phosphorus. Diets were based on corn, wheat, and soybean meal and all nutrients other than protein/amino acids and available phosphorus were maintained at or above breeder guidelines. Additional synthetic amino acids were used in the diets with low protein concentration in attempt to maintain digestible amino acid supply. Diets were offered to 7 replicate pens of 15 chicks per pen from day 8 to 35. Growth performance was measured during the grower (day 8–24) and finisher (day 25–35) periods. On day 35 carcass composition was determined, blood was drawn for various biochemical measurements and the tibia was excised for mechanical and compositional analyses. Birds that received the low-protein diet had lower terminal body weight and higher feed conversion ratio compared with those that received diets with adequate crude protein content. However, addition of available phosphorus to the low-protein diet resulted in significant reductions in weight-corrected feed conversion that were not evident in the diet with adequate protein content. Bone architecture was only moderately influenced by dietary treatment but birds that ingested the diets containing low and medium protein concentrations had relatively heavier abdominal fat pad weight. Blood biochemistry, especially ammonia, uric acid, and phosphorus, was influenced by both dietary protein and available phosphorus and trends suggested that both axes are involved in protein accretion and catabolism. It can be concluded that performance losses associated with feeding low protein diets to broiler chickens may be partially restored by additional available phosphorus. The implications for use of exogenous enzymes such as protease and phytase and protein nutrition per se warrants further examination.

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Section: Introductionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Possible role of available phosphorus in potentiating the use of low-protein diets for broiler chicken production

Cowieson

Perez-Maldonado²,

Kumar

et al. 2020

Poultry Science

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“…In the LP diet experiment, PUN decreased significantly as P intake increased to 0•3 %P, which reflects an enhanced protein anabolism as P intake increases from deficient to standard level. This is in accordance with Raji et al (37) , who revealed that P-containing diets were associated with a reduced PUN and an increase in body protein %, hence implying that protein metabolism was affected by the P level in the diet. Correspondingly, P supplementation of low-protein diets was able to improve total body protein content and reduce urinary nitrogen excretion and thus improved protein anabolism (30) .…”

Section: Discussionsupporting

confidence: 92%

Daily energy expenditure in rats following structured exercise training is affected by dietary phosphorus content

et al. 2020

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P ingestion has been found to alter energy balance, while regular physical exercise (E) was reported to be associated with energy compensation. However, it is not clear whether dietary P would affect energy compensation following structured E. Two experiments were performed, low P (LP) (0·1, 0·2 and 0·3 %P) and high P (HP) (0·3 , 0·6 and 1·2 %P) diets. In each experiment, male rats were randomly divided into three groups (n 8), in which a sedentary or a moderate-intensity exercise routine (30 min 5 d a week) was implemented. Energy intake (EI); efficiency and stores; body measures and total energy expenditure (TEEx) were monitored for 6 weeks. In the LP experiment, EI and weight gain were the lowest in the 0·1 and 0·2 %P as compared with the 0·3 %P. In the HP experiment, EI was highest in the high P (0·6 and 1·2 %P) groups, while weight gain was reduced. In both experiments, exercise was able to reduce body fat accumulation and to maintain a higher % lean body mass. In the LP diets experiment, the similarity in TEEx between the sedentary and exercising groups suggests the probability of a reduction in normal daily activities, which indicates the presence of compensation for the energy expended during exercise by a subsequent reduction in EE. In contrast, the elevated TEEx in the HP exercising groups (0·6 and 1·2 %P) argue against the presence of energy compensation. In conclusion, high dietary P decreases the body’s capability to compensate for the energy deficit induced by E, consequently maintaining an elevated TEEx.

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Dynamic responses of blood metabolites to nutrient depletion and repletion in broiler chicken nutrition

Cowieson,

Phillips,

Mullenix

et al. 2024

Poultry Science

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Concomitant lysine and phosphorus addition to a wheat gluten protein diet highly amplified growth measures of rats

Cited by 5 publications

References 46 publications

Possible role of available phosphorus in potentiating the use of low-protein diets for broiler chicken production

Possible role of available phosphorus in potentiating the use of low-protein diets for broiler chicken production

Daily energy expenditure in rats following structured exercise training is affected by dietary phosphorus content

Dynamic responses of blood metabolites to nutrient depletion and repletion in broiler chicken nutrition

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