Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice

Vignisse, Julie; Steinbusch, Harry W.M.; Grigoriev, V. V.; Bolkunov, Alexei; Прошин, А. Н.; Bettendorff, Lucien; Бачурин, С. О.; Strekalova, Tatyana

doi:10.1016/j.euroneuro.2013.06.010

Cited by 25 publications

(29 citation statements)

References 44 publications

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“…Although it is possible that the different behavioral tests may affect subsequent tests, previously published test batteries with similarly employed paradigms have revealed an absence of any testing effects in C57Bl/6J mice (Malatynska et al, 2012;Strekalova & Steinbusch, 2009Vignisse et al, 2011Vignisse et al, , 2013). Hence, we considered possible interfering effects of multiple behavioral test to be minimal in the current study.…”

Section: Experimental Conditions and Study Outlinementioning

confidence: 99%

“…The next day (day 1), mice were tested in the elevated O-maze and food displacement tube tests (Strekalova & Steinbusch, 2010). On days 2 and 3, respectively, contextual fear conditioning training and testing for recall (Vignisse et al, 2013) were performed.…”

Section: Experimental Conditions and Study Outlinementioning

confidence: 99%

“…The step-down passive avoidance test was used as described elsewhere (Strekalova et al, 2001;Vignisse et al, 2011Vignisse et al, , 2013. The step-down apparatus (Evolocus LLC Tarrytown, NY and Technosmart, Rome, Italy) was a transparent plastic cubicle (25 cm Â 25 cm Â 48 cm) with a stainless-steel grid floor (33 rods 2 mm in diameter), onto which a square wooden platform (7 cm Â 7 cm Â 1.5 cm) was placed.…”

Section: Behavioral Proceduresmentioning

confidence: 99%

“…Understanding changes in relative-fold mRNA expression of NMDAR subunits in animal models of cognitive and emotional disturbances related to chronic stress is important for the identification of new pharmacological interventions and therapies that effectively alter glutamatergic transmission (Vignisse et al, 2013). Previous work on gene expression has highlighted abnormal hippocampal expression of NMDAR subunits in mice subjected to repeated stressors.…”

Section: Introductionmentioning

confidence: 99%

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Altered emotionality, hippocampus-dependent performance and expression of NMDA receptor subunit mRNAs in chronically stressed mice

Costa-Nunes

Зубарева

Araújo-Correia

et al. 2013

Stress

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N-Methyl-D-aspartate receptor (NMDAR)-mediated neurotransmission in the hippocampus is implicated in cognitive and emotional disturbances during stress-related disorders. Here, using quantitative RT-PCR, we investigated the hippocampal expression of NR2A, NR2B and NR1 subunit mRNAs in a mouse stress paradigm that mimics clinically relevant conditions of simultaneously affected emotionality and hippocampus-dependent functions. A 2-week stress procedure, which comprised ethologically valid stressors, exposure to a rat and social defeat, was applied to male C57BL/6J mice. For predation stress, mice were introduced into transparent containers that were placed in a rat home cage during the night; social defeat was applied during the daytime using aggressive CD1 mice. This treatment impaired hippocampusdependent performance during contextual fear conditioning. A correlation between this behavior and food displacement performance was demonstrated, suggesting that burrowing behavior is affected by the stress procedure and is hippocampus-dependent. Stressed mice (n ¼ 22) showed behavioral invigoration and anomalous anxiolytic-like profiles in the O-maze and brightly illuminated open field, unaltered short-term memory in the step-down avoidance task and enhanced aggressive traits, as compared to non-stressed mice (n ¼ 10). Stressed mice showed increased basal serum corticosterone concentrations, hippocampal mRNA expression for the NR2A subunit of the NMDAR and in the NR2A/NR2B ratio; mRNA expression of NR2B and NR1 was unchanged. Thus, stress-induced aberrations in both hippocampal-dependent performance and emotional abnormalities are associated with alterations in hippocampal mRNA NR2A levels and the NR2A/NR2B ratio and not with mRNA expression of NR2B or NR1.

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Section: Experimental Conditions and Study Outlinementioning

confidence: 99%

Section: Experimental Conditions and Study Outlinementioning

confidence: 99%

Section: Behavioral Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered emotionality, hippocampus-dependent performance and expression of NMDA receptor subunit mRNAs in chronically stressed mice

Costa-Nunes

Зубарева

Araújo-Correia

et al. 2013

Stress

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“…18 The apparatus used consisted of an acrylic box (30x30x45cm) with a stainless steel grid floor, having a shock free zone (SFZ) (central platform) on the center of the grid floor. The grid floor was connected to a shock device which delivers foot shocks (20 V AC).…”

Section: Experimental Designmentioning

confidence: 99%

Effect of flunarizine on memory function by using step down passive avoidance test in albino rats

Shinde

Yegnanarayan

Doshi

et al. 2017

Int J Basic Clin Pharmacol

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Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease

Shevtsova

Maltsev

Vinogradova

et al. 2020

Medicinal Research Reviews

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The mitochondria‐targeting drugs can be conventionally divided into the following groups: those compensating for the energy deficit involved in neurodegeneration, including stimulants of mitochondrial bioenergetics and activators of mitochondrial biogenesis; and neuroprotectors, that are compounds increasing the resistance of mitochondria to opening of mitochondrial permeability transition (MPT) pores. Although compensating for the energy deficit and inhibition of MPT are obvious targets for drugs used in the very early stages of Alzheimer‐like pathology, but their use as the monotherapy for patients with severe symptoms is unlikely to be sufficiently effective. It would be optimal to combine targets that would provide the cognitive‐stimulating, the neuroprotective effects and the ability to affect specific disease‐forming mechanisms. In the design of such drugs, assessment of their potential mitochondrial‐targeted effects is of particular importance. The possibility of targeted drug design for simultaneous action on mitochondrial and neurotransmitter's receptors targets is, in particularly, based on the known interplay of various cellular pathways and the presence of common structural components. Of particular interest is directed search for multitarget drugs that would act simultaneously on mitochondrial calcium‐dependent functions, the targets (receptors, enzymes, etc.) facilitating neurotransmission, and the molecular targets related to the action of so‐called disease‐modifying factors, in particular, the formation and overcoming of the toxicity of β‐amyloid or hyperphosphorylated tau protein. The examples of such approaches realized on the level of preclinical and clinical trials are presented below.

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Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice

Cited by 25 publications

References 44 publications

Altered emotionality, hippocampus-dependent performance and expression of NMDA receptor subunit mRNAs in chronically stressed mice

Altered emotionality, hippocampus-dependent performance and expression of NMDA receptor subunit mRNAs in chronically stressed mice

Effect of flunarizine on memory function by using step down passive avoidance test in albino rats

Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease

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