2020
DOI: 10.1007/s10067-020-05310-1
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Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology

Abstract: In the midst of the COVID-19 pandemic, further understanding of its complications points towards dysregulated immune response as a major component. Systemic lupus erythematosus (SLE) is also a disease of immune dysregulation leading to multisystem compromise. We present a case of new-onset SLE concomitantly with COVID-19 and development of antiphospholipid antibodies. An 18-year-old female that presented with hemodynamic collapse and respiratory failure, progressed to cardiac arrest, and had a pericardial tamp… Show more

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Cited by 93 publications
(108 citation statements)
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“…Five cases (63%) occurred in patients with previous history of SLE (one case with associated antiphospholipid syndrome and another case with end-stage renal disease secondary to WHO Class IV lupus nephritis) [11,12,14,16,17]. The nonspeci c clinical manifestations reported were fever in 5 cases [12,13,16,17 and present report], malaise in 3 cases [13,17 and present report], 1 case with headache [14] and 1 case with myalgia and arthralgia [present report]). Organ-speci c manifestations reported were pulmonary (cough in 4 cases [13,14,17 and present report], shortness of breath in 4 cases [12][13][14], chest discomfort in 1 case [11] and peripheral cyanosis in 1 case [15]), cardiovascular (2 cases with circulatory collapse [13,15]), hematological (hemoptysis in 1 case [16], gingival bleeding in 1 case [11] and 1 case with diffuse purpuric rash [14] [11,13,14], positive anticardiolipin antibodies in 2 cases [13,14], and positive anti-β2-glycoprotein 1 antibodies in 2 cases [13,14].…”
Section: Resultsmentioning
confidence: 67%
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“…Five cases (63%) occurred in patients with previous history of SLE (one case with associated antiphospholipid syndrome and another case with end-stage renal disease secondary to WHO Class IV lupus nephritis) [11,12,14,16,17]. The nonspeci c clinical manifestations reported were fever in 5 cases [12,13,16,17 and present report], malaise in 3 cases [13,17 and present report], 1 case with headache [14] and 1 case with myalgia and arthralgia [present report]). Organ-speci c manifestations reported were pulmonary (cough in 4 cases [13,14,17 and present report], shortness of breath in 4 cases [12][13][14], chest discomfort in 1 case [11] and peripheral cyanosis in 1 case [15]), cardiovascular (2 cases with circulatory collapse [13,15]), hematological (hemoptysis in 1 case [16], gingival bleeding in 1 case [11] and 1 case with diffuse purpuric rash [14] [11,13,14], positive anticardiolipin antibodies in 2 cases [13,14], and positive anti-β2-glycoprotein 1 antibodies in 2 cases [13,14].…”
Section: Resultsmentioning
confidence: 67%
“…Organ-speci c manifestations reported were pulmonary (cough in 4 cases [13,14,17 and present report], shortness of breath in 4 cases [12][13][14], chest discomfort in 1 case [11] and peripheral cyanosis in 1 case [15]), cardiovascular (2 cases with circulatory collapse [13,15]), hematological (hemoptysis in 1 case [16], gingival bleeding in 1 case [11] and 1 case with diffuse purpuric rash [14] [11,13,14], positive anticardiolipin antibodies in 2 cases [13,14], and positive anti-β2-glycoprotein 1 antibodies in 2 cases [13,14]. Reported SLE activity was hematologic in 6 patients [11,13- [13,17]. The diagnosis of SARS-CoV-2 infection was made by PCR test in 7 patients [11][12][13][14]16,17] and by serologic test in 1 patient [15].…”
Section: Resultsmentioning
confidence: 74%
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