Concomitant palonosetron ameliorates cisplatin-induced nephrotoxicity, nausea, and vomiting: a retrospective cohort study and pharmacovigilance analysis

Takemura, Miho; Ikemura, Kenji; Kondo, Motoi; Yamane, Fumihiro; Ueda, Masao; Okuda, Masahiro

doi:10.1186/s40780-022-00252-z

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Therefore, protecting the renal function during administration is needed. However, a study indicated that the first-generation 5-HT 3 R antagonists (ondansetron, granisetron, tropisetron) exacerbated cisplatin-induced renal injury, whereas the second-generation 5-HT 3 R antagonists (palonosetron) showed greater anti-cisplatin-induced nephrotoxicity than other 5-HT 3 R antagonists [114, 115]. A study reported that ondansetron is associated with an increasing risk of AKI [116].…”

Section: Protective Effects and The Latest Research Of Sedative And A...mentioning

confidence: 99%

Future Directions in Optimizing Anesthesia to Reduce Perioperative Acute Kidney Injury

Zeng,

Liu,

et al. 2023

Am J Nephrol

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Background: Perioperative acute kidney injury (AKI) is common in surgical patients and is associated with high morbidity and mortality. There are currently few options for AKI prevention and treatment. Due to its complex pathophysiology, there is no efficient medication therapy to stop the onset of the injury or repair the damage already done. Certain anesthetics, however, have been demonstrated to affect the risk of perioperative AKI in some studies. The impact of anesthetics on renal function is particularly important, as it is closely related to the prognosis of patients. Some anesthetics can induce anti-inflammatory, anti-necrotic and anti-apoptotic effects. Propofol, sevoflurane, and dexmedetomidine (DEX) are a few examples of anesthetics that have protective association with AKI in the perioperative period. Summary: In this study, we reviewed the clinical characteristics, risk factors and pathogenesis of AKI. Subsequently, the protective effects of various anesthetic agents against perioperative AKI and the latest research are then introduced. Key message: This work demonstrates that a thorough understanding of the reciprocal effects of anesthetic drugs and AKI is crucial for safe perioperative care and prognosis of patients. However, more complete mechanisms and pathophysiological processes still need to be further studied.

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Section: Protective Effects and The Latest Research Of Sedative And A...mentioning

confidence: 99%

Future Directions in Optimizing Anesthesia to Reduce Perioperative Acute Kidney Injury

Zeng,

Liu,

et al. 2023

Am J Nephrol

View full text Add to dashboard Cite

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Multiple drugs

2022

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Effect of Hydration with Bicarbonate Ringer’s Solution on Cisplatin-Induced Acute Kidney Injury in Patients with Esophageal Cancer: A Retrospective Cohort Study

Takemura,

Ikemura,

Okuda

2024

Oncology

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Introduction: Cisplatin (CDDP) often causes acute kidney injury (AKI), and magnesium supplementation has been suggested to be important in preventing CDDP-induced AKI. Sodium bicarbonate Ringer’s solution (BRS) is a crystalloid solution composed of various electrolytes, including Mg2+, and can be generally used to supplement missing extracellular fluid and correct metabolic acidosis; however, the clinical outcomes of hydration with BRS for CDDP-induced AKI remain unclear. In this study, we retrospectively compared the effects of BRS and normal saline for hydration in patients undergoing CDDP treatment. Methods: We analyzed the incidence rate of AKI (grade ≥ 1), the severity of AKI, the serum magnesium level, and the incidence rate of grade ≥ 3 hematological toxicities (leukopenia, neutropenia, anemia, or thrombocytopenia) following CDDP and fluorouracil (5-FU) administration in 131 in-patients who received CDDP and 5-FU for the first time to treat esophageal cancer. Results: Fifty-six patients (43%) received saline alone, while 75 patients (57%) received BRS for hydration. The incidence rate of AKI (grade ≥ 1) was significantly lower in the BRS group (11%) than that in the saline group (39%, p < 0.001). Moreover, severe AKI (grade ≥ 2) was significantly less common in the BRS group than in the saline group. Although the serum magnesium levels before CDDP administration were not significantly different between the two groups (p = 0.939), the serum magnesium levels on days 2–3 after CDDP administration in the BRS group were significantly higher than those in the saline group (p < 0.001). In contrast, there were no significant differences in the incidence rates of hematological toxicity between the two groups. Multivariate analysis revealed that BRS use was an independent factor that significantly contributed to AKI prevention (odds ratio = 0.061, p < 0.001). Conclusion: Hydration with BRS could prevent CDDP-induced AKI in patients with esophageal cancer.

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Concomitant palonosetron ameliorates cisplatin-induced nephrotoxicity, nausea, and vomiting: a retrospective cohort study and pharmacovigilance analysis

Cited by 4 publications

References 21 publications

Future Directions in Optimizing Anesthesia to Reduce Perioperative Acute Kidney Injury

Future Directions in Optimizing Anesthesia to Reduce Perioperative Acute Kidney Injury

Multiple drugs

Effect of Hydration with Bicarbonate Ringer’s Solution on Cisplatin-Induced Acute Kidney Injury in Patients with Esophageal Cancer: A Retrospective Cohort Study

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