Concomitant Parvimonas micra Septic Arthritis and Pseudogout After Total Knee Arthroplasty

Bangert, Elvira; Hofkirchner, Alexander; Towheed, Tanveer

doi:10.1097/rhu.0000000000000728

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…micra is an extremely rare pathogen in the setting of PJI, with a very limited number of reported cases (Table 1). To our knowledge, there are only 2 reported cases in the literature of TKA PJI secondary to P. micra [17,23]. Another 5 cases of P. micra causing a native joint infection have been reported [18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 98%

“…Another 5 cases of P. micra causing a native joint infection have been reported [18][19][20][21][22]. All the reported patients were either advanced in age or immunocompromised, and the majority of them had significant dental histories requiring aggressive treatment [17][18][19]21,23]. Moreover, 4 reported cases of P. micra infection occurred in the setting of calcium pyrophosphate deposition disease [18,20,22,23].…”

Section: Discussionmentioning

confidence: 99%

“…All the reported patients were either advanced in age or immunocompromised, and the majority of them had significant dental histories requiring aggressive treatment [17][18][19]21,23]. Moreover, 4 reported cases of P. micra infection occurred in the setting of calcium pyrophosphate deposition disease [18,20,22,23]. Follow-up information regarding postoperative knee functionality was discussed in 4 patients, of which 2 regained complete ROM [17,22], one required a cane to ambulate [19], and one became wheelchair-bound [18].…”

Section: Discussionmentioning

confidence: 99%

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Atypical Presentation of Periprosthetic Joint Infection After Total Knee Arthroplasty due to Parvimonas micra

et al. 2020

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There is limited literature reporting the oral pathogen Parvimonas micra as the causative organism of periprosthetic joint infection. Previous reports demonstrate septic arthritis in native or prosthetic joints due to P. micra in elderly or immunocompromised patients associated with tooth abscess and periodontal disease. Our case report is unique because it describes a healthy individual with recurrent gingivitis developing periprosthetic joint infection after total knee arthroplasty as the result of isolated P. micra. Her clinical symptom presented early and manifested as progressive stiffness only. Timely aspiration resulted in early diagnosis, but the patient still underwent 2-stage revision with a more constrained implant. To prevent the risk of infection by oral pathogens such as P. micra, dental history should be thoroughly investigated, and any lingering periodontal infection should be addressed before any arthroplasty operation.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Atypical Presentation of Periprosthetic Joint Infection After Total Knee Arthroplasty due to Parvimonas micra

et al. 2020

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“…In terms of prognosis, 72 patients (87.80%) exhibited a gradual recovery from the infection, while 10 patients (12.20%) succumbed to multiorgan failure (14,36,(39)(40)(41)(42)(43)(44), the majority of whom presented severe comorbid underlying conditions such as cardiovascular diseases, neoplasms, and immune-related diseases. This underscores the imperative need for heightened vigilance regarding P. micra infection, particularly in individuals predisposed to compromised oral hygiene, diabetes mellitus, malignancy, and cardiovascular and cerebrovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Hemoptysis caused by Parvimonas micra: case report and literature review

Shao,

He,

Jiao

et al. 2024

Front. Public Health

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BackgroundParvimonas micra (P. micra), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for P. micra-related diseases encounters delays, often with severe consequences, including fatality, attributed to the absence of symptom specificity and challenges in culture. The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. This study aims to elucidate and scrutinize the clinical manifestations linked to P. micra, drawing insights from an extensive literature review of pertinent case reports.Case presentationA 53-year-old male sought medical attention at our institution presenting with recurrent hemoptysis. Empirical treatment was initiated while awaiting pathogen culture results; however, the patient’s symptoms persisted. Subsequent metagenomic next-generation sequencing (mNGS) analysis revealed a pulmonary infection attributable to P. micra. Resolution of symptoms occurred following treatment with piperacillin sulbactam sodium and moxifloxacin hydrochloride. A comprehensive literature review, utilizing the PubMed database, was conducted to assess case reports over the last decade where P. micra was identified as the causative agent.ConclusionThe literature analysis underscores the predilection of P. micra for immunocompromised populations afflicted by cardiovascular diseases, diabetes, orthopedic conditions, and tumors. Risk factors, including oral and periodontal hygiene, smoking, and alcohol consumption, were found to be associated with P. micra infections. Clinical manifestations encompassed fever, cough, sputum production, and back pain, potentially leading to severe outcomes such as Spondylodiscitis, septic arthritis, lung abscess, bacteremia, sepsis, and mortality. While conventional bacterial culture remains the primary diagnostic tool, emerging technologies like mNGS offer alternative considerations. In terms of treatment modalities, β-lactam antibiotics and nitroimidazoles predominated, exhibiting recovery rates of 56.10% (46/82) and 23.17% (19/82), respectively. This case report and literature review collectively aim to enhance awareness among clinicians and laboratory medicine professionals regarding the intricacies of P. micra-associated infections.

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Colchicine

2019

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Concomitant Parvimonas micra Septic Arthritis and Pseudogout After Total Knee Arthroplasty

Cited by 6 publications

References 30 publications

Atypical Presentation of Periprosthetic Joint Infection After Total Knee Arthroplasty due to Parvimonas micra

Atypical Presentation of Periprosthetic Joint Infection After Total Knee Arthroplasty due to Parvimonas micra

Hemoptysis caused by Parvimonas micra: case report and literature review

Colchicine

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