Concomitant presentation of multiple vertebral and peripheral osteonecrosis in a HIV-infected patient

Vertebral Osteonecrosis in An HIV-Infected Patient

“…VON has been associated with other traditional risk factors for peripheral osteonecrosis [3]; however, its association with HIV infection has not been previously reported in any of the large series of osteonecrosis in HIV-infected patients [1,2]. Our group reported the first case of VON in a long-term HIV-infected patient receiving HAART who presented several concurrent risk factors for both osteonecrosis and osteoporosis, and who developed concomitantly multiple osteonecrosis in several vertebral bodies and peripheral locations [6]. The present case had no traditional risk factors for osteonecrosis, but he presented other factors related with HIV infection, such as severe immunosuppression and low nadir CD4 + T-cell count [1,2].…”

“…HIV-infected patients have an increased prevalence of osteoporosis and vertebral fractures [4] and, recently, it has been reported that osteoporosis and osteonecrosis occur concurrently in HIV-infected patients more often than expected [5]; therefore, vertebral osteonecrosis (VON) occurrence could be expected in these patients. However, VON is not reported in any of the large studies of HIVassociated osteonecrosis [1,2] and there is only one published case to-date [6].…”