Concomitant Pulmonary Aspergillosis and Nocardiosis in a Patient With Chronic Granulomatous Disease of Childhood

Nocardia and Aspergillus Pulmonary Infection in a Patient on Long-Term Steroid Treatment: Case Report and Literature Review

“…Concurrent pulmonary infections with one or more opportunistic pathogens pose a greater challenge to both the diagnostic strategy and the therapeutic approach. Concomitant Aspergillus and Nocardia pulmonary infections have been reported previously, including cases of organ transplants, chronic graft-versus-host disease, and chronic granulomatous disease (1)(2)(3)(4). To the best of our knowledge, this is likely the second case report of dual Aspergillus and Nocardia infection in a patient on long-term steroid treatment.…”

Disseminated Nocardiosis in a Patient with X‐Linked Chronic Granulomatous Disease and Human Immunodeficiency Virus Infection

“…The search for other concomitant infections in the immunocompromised host presenting with one infection was justified in this case, as has been suggested in the literature [17,18]. Despite the initial suspicion that the patient's wrist lesion represented a third focus of Nocardia infection, a fungal pathogen requiring different treatment was identified.…”

Microgranulomatous aspergillosis after shoveling wood chips: Report of a fatal outcome in a patient with chronic granulomatous disease

“…Several reports describe clinical-pathological features relevant in part to our patient, although no point source was found. Casale and later Chusid described four children with aspergillus infections associated with a diffuse nodular pattern on x-ray and a granulomatous inflammatory response [Casale et al, 1984;Chusid et al, 19881. A histologic pattern much like that in our case occurred in a patient with CGD who died following a huge fungal inoculum from shoveling moldy barley [Kelly et al, 19861.…”

“…A diagnostic approach including bronchoscopy and open lung biopsy should be used to make an early diagnosis and initiate appropriate therapy. Therapy may include antifungal agents such as amphotericin B and itraconazole [Casale et al, 1984;Chusid et al, 1988;van't Wout et al, 19901 as well as experimental interventions such as y interferon [Newberger and Eskowitz, 1988;Bernhisel-Broadbent, 199 11. However, the efficacy of these therapeutic interventions may be limited, if, as this case suggests, the host response rather than the agent pathogenicity dictates the clinical course.…”