Concomitant Urothelial Cancer and Renal Tuberculosis

Abstract

We report a case of coexisting urothelial cancer and renal tuberculosis in the same kidney. The patient is a 72-year-old female with a remote history of treated pulmonary tuberculosis who presented with haematuria, initial investigation of which elucidated no definitive cause. Almost 1 year later, a diagnosis of metastatic urinary tract cancer was made. The patient received chemotherapy for advanced collecting duct type renal cell carcinoma, based on histological features of renal biopsy. Subsequent confirmatory immunostains however led to a revised diagnosis of urothelial cancer, necessitating a change in chemotherapy regimen. A diagnosis of ipsilateral renal tuberculosis was made based on TB-PCR testing of renal biopsy tissue and anti-TB therapy was coadministered with chemotherapy. The patient died 9 months after diagnosis of metastatic urothelial cancer.

Factors Influencing the Development of Urothelial Lesions and Breast Tuberculosis among Pulmonary TB Patients Undergoing Directly Observed Therapy in Abeokuta and Ilishan Metropolises, Ogun State, Nigeria

“…The higher cases of haematuria associated with urothelial lesions observed among female TB infected patients (table 4) further lends support to the fact that females have increased risk of developing urothelial lesions compared with their male counterparts. This is consonance with the findings of Chin et al [40] Since the number of female smokers was quite low in this study compared with their male counterparts (table 1), life-style may not have contributed to the urothelial lesions among them.…”

Concomitant squamous cell carcinoma of the bladder and renal tuberculosis: A case report from northern Tanzania

“…Retrospective studies have shown there is no difference in clinical response of anti‐TB drugs in patients receiving chemotherapy 7,8 . A review study by Nair et al showed that there was no risk of TB reactivation while using anticancer chemotherapy in patients with the history of TB 9 .…”

“…Retrospective studies have shown there is no difference in clinical response of anti‐TB drugs in patients receiving chemotherapy. 7 , 8 A review study by Nair et al showed that there was no risk of TB reactivation while using anticancer chemotherapy in patients with the history of TB. 9 In another case report of concomitant SCC and TB of obturator lymphnode, it was both possible to control locoregional recurrence of the tumor and TB by administering anti‐TB for 6 weeks followed by four cycles of gemcitabine and cisplatin‐based chemotherapy with anti‐TB.…”

Coexistence of urinary tuberculosis and urothelial carcinoma: A case report

“…The simultaneous occurrence of both diseases in the same patient may be explained by the fact that tuberculosis may cause a long-term local inflammatory response, which may in turn induce cellular carcinogenesis. This could be further explained by the relationship between pulmonary tuberculosis and lung cancer[ 4 ], and ulcerative lesions of intestinal tuberculosis acting as a precursor to intestinal mucosal cancer[ 5 ]. Mycobacterium tuberculosis may also promote the development of cancer by inducing a chronic inflammatory state and compromising T cell-mediated immunity[ 6 ].…”