Concomitant Use of Sulforaphane Enhances Antitumor Efficacy of Sunitinib in Renal Cell Carcinoma In Vitro

Tsaur, Igor; Thomas, Anita; Taşkıran, Emine; Rutz, Jochen; Chun, Felix K.‐H.; Haferkamp, Axel; Juengel, Eva; Blaheta, Roman A.

doi:10.3390/cancers14194643

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Short-term SFN application reduced cell numbers across diverse lines, sensitizing RCC cells to ST. Long-term SFN use exhibited greater effectiveness, particularly in 786O cells, where the ST-SFN combination outperformed SFN alone [74]. These findings underscore SFN's significant anticancer potential in countering tumor reactivation and resistance, propelling further clinical research.…”

Section: Sfn As An Anticancer Agentmentioning

confidence: 76%

Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Otoo,

Allen

2023

Molecules

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Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. It has been widely studied for its potential as a neuroprotective and anticancer agent. This review aims to critically evaluate the current evidence supporting the neuroprotective and anticancer effects of SFN and the potential mechanisms through which it exerts these effects. SFN has been shown to exert neuroprotective effects through the activation of the Nrf2 pathway, the modulation of neuroinflammation, and epigenetic mechanisms. In cancer treatment, SFN has demonstrated the ability to selectively induce cell death in cancer cells, inhibit histone deacetylase, and sensitize cancer cells to chemotherapy. SFN has also shown chemoprotective properties through inhibiting phase I metabolizing enzymes, modulating phase II xenobiotic-metabolizing enzymes, and targeting cancer stem cells. In addition to its potential as a therapeutic agent for neurological disorders and cancer treatment, SFN has shown promise as a potential treatment for cerebral ischemic injury and intracranial hemorrhage. Finally, the ongoing and completed clinical trials on SFN suggest potential therapeutic benefits, but more research is needed to establish its effectiveness. Overall, SFN holds significant promise as a natural compound with diverse therapeutic applications.

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Section: Sfn As An Anticancer Agentmentioning

confidence: 76%

Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Otoo,

Allen

2023

Molecules

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“…In addition, SFN augmented the anti-cancer efficacy of sunitinib in renal cell carcinoma (RCC) by diminishing cell growth and proliferation. The combination treatment induced G2/M phase arrest by suppressing cyclin A, cyclin B, CDK1, p-CDK1, CDK2, and p-CDK2 in RCC cell lines [123].…”

Section: Other Cancersmentioning

confidence: 94%

Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review

Sailo,

Liu,

Chauhan

et al. 2024

Cancers

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Recent advances in oncological research have highlighted the potential of naturally derived compounds in cancer prevention and treatment. Notably, sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables including broccoli and cabbage, has exhibited potent chemosensitizing capabilities across diverse cancer types of bone, brain, breast, lung, skin, etc. Chemosensitization refers to the enhancement of cancer cell sensitivity to chemotherapy agents, counteracting the chemoresistance often developed by tumor cells. Mechanistically, SFN orchestrates this sensitization by modulating an array of cellular signaling pathways (e.g., Akt/mTOR, NF-κB, Wnt/β-catenin), and regulating the expression and activity of pivotal genes, proteins, and enzymes (e.g., p53, p21, survivin, Bcl-2, caspases). When combined with conventional chemotherapeutic agents, SFN synergistically inhibits cancer cell proliferation, invasion, migration, and metastasis while potentiating drug-induced apoptosis. This positions SFN as a potential adjunct in cancer therapy to augment the efficacy of standard treatments. Ongoing preclinical and clinical investigations aim to further delineate the therapeutic potential of SFN in oncology. This review illuminates the multifaceted role of this phytochemical, emphasizing its potential to enhance the therapeutic efficacy of anti-cancer agents, suggesting its prospective contributions to cancer chemosensitization and management.

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“…Due to their effects on both plants and humans, GSLs are a current biology research focus [4][5][6][7][8][9]. Indeed, rapeseed breeders focus on harmful GSLs in rapeseed cakes, vegetable breeders are more interested in anticancer GSLs that are beneficial to humans, and medical scientists focus on GSLs that are inhibitory to tumor cells [10][11][12][13][14]. Sulforaphane, a secondary metabolite, relieves neuropathic pain caused by chemotherapy and inhibits prostate, colon, breast, pancreatic, and bladder cancers [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Glucosinolate Biosynthetic Genes of Cabbage: Genome-Wide Identification, Evolution, and Expression Analysis

Wang

Cao

Yang

et al. 2023

Genes

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Cabbage (Brassica oleracea var. capitata) is a vegetable rich in glucosinolates (GSLs) that have proven health benefits. To gain insights into the synthesis of GSLs in cabbage, we systematically analyzed GSLs biosynthetic genes (GBGs) in the entire cabbage genome. In total, 193 cabbage GBGs were identified, which were homologous to 106 GBGs in Arabidopsis thaliana. Most GBGs in cabbage have undergone negative selection. Many homologous GBGs in cabbage and Chinese cabbage differed in expression patterns indicating the unique functions of these homologous GBGs. Spraying five exogenous hormones significantly altered expression levels of GBGs in cabbage. For example, MeJA significantly upregulated side chain extension genes BoIPMILSU1-1 and BoBCAT-3-1, and the expression of core structure construction genes BoCYP83A1 and BoST5C-1, while ETH significantly repressed the expression of side chain extension genes such as BoIPMILSU1-1, BoCYP79B2-1, and BoMAMI-1, and some transcription factors, namely BoMYB28-1, BoMYB34-1, BoMYB76-1, BoCYP79B2-1, and BoMAMI-1. Phylogenetically, the CYP83 family and CYP79B and CYP79F subfamilies may only be involved in GSL synthesis in cruciferous plants. Our unprecedented identification and analysis of GBGs in cabbage at the genome-wide level lays a foundation for the regulation of GSLs synthesis through gene editing and overexpression.

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Concomitant Use of Sulforaphane Enhances Antitumor Efficacy of Sunitinib in Renal Cell Carcinoma In Vitro

Cited by 4 publications

References 32 publications

Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review

Glucosinolate Biosynthetic Genes of Cabbage: Genome-Wide Identification, Evolution, and Expression Analysis

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