Concomitant western diet and chronic-binge alcohol dysregulate hepatic metabolism

Buyco, Delfin; Dempsey, Joseph L.; Scorletti, Eleonora; Jeon, Sookyoung; Lin, Chun-Yao; Harkin, Julia; Bayen, Susovon; Furth, Emma E.; Martin, Jasmin; Delima, Monique; Hooks, Royce; Sostre-Colón, Jaimarie; Gharib, Sina A.; Titchenell, Paul M.; Carr, Rotonya M.

doi:10.1371/journal.pone.0281954

Cited by 4 publications

(2 citation statements)

References 59 publications

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“…Interestingly recent studies reported that ethanol in drinking water and/or binge ethanol intake exacerbated liver injury in mice fed the Western diet (141,142), which is required further characterization.…”

Section: Alcohol-associated Liver Cancermentioning

confidence: 99%

Alcohol-associated liver disease

Mackowiak,

Fu,

Maccioni

et al. 2024

Journal of Clinical Investigation

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Section: Alcohol-associated Liver Cancermentioning

confidence: 99%

Alcohol-associated liver disease

Mackowiak,

Fu,

Maccioni

et al. 2024

Journal of Clinical Investigation

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“…The study affirms that the Mediterranean diet has significant benefits in managing major chronic diseases such as cardiovascular disease, obesity, diabetes, and some types of cancer, based on its fundamental characteristics. Recently, there has been increasing recognition that the Mediterranean Diet, when combined with fitness along with cognitive behavior therapy, may serve as the optimal nutritional plan for preventing and treating NAFLD patients [72,73]. Moreover, the outcomes of multiple nutritional therapy studies have confirmed the advantageous impacts of the Mediterranean diet on non-alcoholic fatty liver disease (NAFLD).…”

Section: The Topic Of Interest Is the Relationship Between Metabolic ...mentioning

confidence: 99%

Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome

Tarcău,

Vicaș,

Filip

et al. 2023

JPM

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Metabolic syndrome, as a medical condition, presents multifactorial complexity that is characterized by the resulting damage from genetic, environmental, and lifestyle factors (presence or absence of physical activity, food choices). Thus, metabolic syndrome qualifies unequivocally as a medical condition in which there are, simultaneously, several independent metabolic risk factors, namely, abdominal obesity, high triglyceride level, low HDL cholesterol level, arterial hypertension, and high glycemic level. Although age, sex, socio-economic status, and the precise definition of metabolic syndrome all influence the prevalence and risk of developing the condition, clinical and epidemiological studies clearly show that central obesity, as measured by an increased abdominal circumference, is the main risk factor. Thus, due to the growing global incidence of obesity, there has been an increase in the incidence of metabolic syndrome. Starting with obesity, all other metabolic risk factors are influenced: for example, as a result of insulin resistance with hyperglycemia, diabetes is linked to an increased risk of cardiovascular disease due to increased abdominal circumference. Through this review, we aimed to highlight the latest research studies and dietary nutritional interventions useful in the prevention of this disease but also implementation strategies for primary prevention among the healthy population.

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Independent and additive effects of binge drinking and obesity on liver enzymes: a cross-sectional analysis using the Korean National Health Insurance Service data

Kityo,

Lee

2023

Gastroenterology Report

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Background Binge drinking (BD) has been associated with elevated liver enzymes, but the joint association of BD and adiposity with liver enzymes is understudied. We aimed to examine the combined association of BD and obesity with elevated liver enzymes. Methods Data were obtained from 285,600 patients in the Korean National Health check-up program during 2009–2015. Level I BD (BD I) was defined as alcohol consumption of >60 g (men) or >40 g (women) on one occasion in the previous year. High-intensity BD (HIBD) corresponded to at least two times the BD I levels. General and abdominal obesity were defined by body mass index and waist circumference. Logistic regression was used to examine the independent and joint associations of BD and obesity with elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) levels. Relative excess risk (RERI), attributable proportion (AP), and synergy index (SI) were calculated to estimate the additive interaction effects. Results The mean age was 42.1 ± 0.03 years and 50.2% were women. Elevated ALT [odds ratio (OR) 1.09, 95% confidence interval (CI) 1.02–1.16], AST (OR 1.16, 95% CI 1.11–1.23), and GGT (OR 1.84, 95% CI 1.05–1.94) were associated with HIBD. Higher odds of elevated ALT (OR 3.57, 95% CI 3.43–3.71), AST (OR 3.47, 95% CI 3.37–3.58), and GGT (OR 2.10, 95% CI 1.98–2.12) were observed in individuals with general obesity. A similar trend was observed for abdominal obesity. The RERI, AP, and SI for the interaction effect of BD and general obesity were 23%, 7%, and 13% for elevated AST levels, and 67%, 24%, and 58% for elevated GGT levels, respectively. Similar effects were observed for the interaction between BD and abdominal obesity. Conclusions Obesity aggravated the odds of elevated liver AST and GGT levels in HIBD.

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Concomitant western diet and chronic-binge alcohol dysregulate hepatic metabolism

Cited by 4 publications

References 59 publications

Alcohol-associated liver disease

Alcohol-associated liver disease

Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome

Independent and additive effects of binge drinking and obesity on liver enzymes: a cross-sectional analysis using the Korean National Health Insurance Service data

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