Abstract:Patient-derived xenograft(PDX) models of primary lung cancer have been reported. However, varying engraftment rates and their underlying mechanisms for specific subtypes of lung cancer (adenocarcinoma, squamous cell carcinoma, and large cell neuroendocrine carcinoma) have not been studied. The authors prepared subcutaneous tumors grown in NSG™ mice with primary tumors of lung cancer patients to develop lung cancer PDX models. Pathological features of the subcutaneous tumors were compared with those of the pati… Show more
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