Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins

Strachan, David P.; Wong, Hannah J.; Spector, Tim D.

doi:10.1067/mai.2001.119408

Cited by 101 publications

(88 citation statements)

References 35 publications

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“…These diseases are supposed to have a multifactorial background with genetic determinants and environmental factors contributing to their development (von Mutius, 2000;Strachan et al, 2001). Since the changes in prevalence rates cannot be explained by genetic factors alone, aetiologic research focuses on the subjects' environment.…”

Section: Introductionmentioning

confidence: 99%

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

et al. 2005

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Objective: Due to inconsistent results based on dietary intake data, unsaturated fatty acids in red blood cell (RBC) membranes and diet were used to investigate their association with allergic sensitisation and allergic rhinitis. Design: Cross-sectional, population-based study. Setting: Bavarian Nutrition Survey II (2002-03), Germany. Subjects: A total of 568 adult participants, 325 women and 243 men. Methods: By means of logistic regression models, the relation of fatty acids to (i) allergic sensitisation as defined by means of specific serum immunoglobulin E analysis (CAPSX1 class Z2), and (ii) self-reported allergic rhinitis was examined. Results: A high cell membrane level of eicosapentaenoic acid (EPA, 20:5 n-3) was inversely associated with allergic sensitisation, the adjusted odds ratio (OR) and 95% confidence interval (95% CI) were 0.52 (0.30-0.90) for the highest (vs lowest) quartile. A similar effect was observed for allergic rhinitis with an OR (95% CI) of 0.50 (0.24-1.03; P ¼ 0.027 for trend). A higher dietary intake of alpha-linolenic acid (ALA, 18:3 n-3) was associated with a decreased risk of allergic sensitisation and allergic rhinitis with ORs (95% CIs) of 0.51 (0.28-0.93) and 0.43 (0.20-0.93), respectively, in the highest quartiles. No other dietary or cell membrane unsaturated fatty acid was significantly associated with the outcome variables, nor was the n-6/n-3 ratio. The strongest effects were observed among subjects under the age of 40 y. Conclusions: In this cross-sectional study among adults, a high content of n-3 fatty acids in RBC membranes (EPA) or in the diet (ALA) is associated with a decreased risk of allergic sensitisation and allergic rhinitis. Sponsorship: The study was supported by funds of the Kurt-Eberhard-Bode-Stiftung and the Bavarian Ministry of Environment, Health and Consumer Protection.

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Section: Introductionmentioning

confidence: 99%

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

et al. 2005

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“…Systemic, well-powered, genome-wide surveys using GWAS and immunochip analyses have estimated the relationship between SNP and susceptibility to AD. (31,39,40) It is well established that common loss of function variants of FLG are a major predisposing factor for AD. As for example, the FLG mutations are involved in AD and are featured in some review articles.…”

Section: Molecular Genetic Tools Of Atopic Dermatitismentioning

confidence: 99%

“…Studies on twin have provided the role of a genetic background with a concordance rate of 72-86 % in identical twins and 21-23 % in dizygotic twins, indicating high heritability of AD. (30,31) In addition multiple studies on affected individuals and their families have a positive family history of AD. However the heritability of AD was determined at 72 % by study on Norwegian twin.…”

Section: Evidences Of the Genetics Role In Atopic Dermatitismentioning

confidence: 99%

“…However the heritability of AD was determined at 72 % by study on Norwegian twin. (31) Recently, a total of 19 susceptibility loci have been estimated at a genome-wide level of significance. Contribution of such these genetic factors may affect diverse phenotypes of AD among individuals.…”

Section: Evidences Of the Genetics Role In Atopic Dermatitismentioning

confidence: 99%

“…(32) Human genetic variants are either common or rare, common variants, known as polymorphisms and are defined as variants with a minor allele frequency of at least 1% within the population. (30,31) Single nucleotide polymorphisms (SNP) are the most common uses for determining of genetic variations within individuals. (33) Recently GWAS comprehensively surveys associations between SNP in common diseases.…”

Section: Molecular Genetic Tools Of Atopic Dermatitismentioning

confidence: 99%

See 2 more Smart Citations

Molecular Genetic of Atopic Dermatitis : An Update

Al‐Shobaili

Ahmed

Alnomair

et al. 2016

IJHS

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Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The pathogenesis of AD remains unclear, but the disease results from dysfunctions of skin barrier and immune response, where both genetic and environmental factors play a key role. Recent studies demonstrate the substantial evidences that show a strong genetic association with AD. As for example, AD patients have a positive family history and have a concordance rate in twins. Moreover, several candidate genes have now been suspected that play a central role in the genetic background of AD. In last decade advanced procedures similar to genome-wide association (GWA) and single nucleotide polymorphism (SNP) have been applied on different population and now it has been clarified that AD is significantly associated with genes of innate/adaptive immune systems, human leukocyte antigens (HLA), cytokines, chemokines, drug-metabolizing genes or various other genes. In this review, we will highlight the recent advancements in the molecular genetics of AD, especially on possible functional relevance of genetic variants discovered to date.

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Pathogenesis—Immunopathogenesis

Roosje

2013

Veterinary Allergy

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Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins

Cited by 101 publications

References 35 publications

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

Molecular Genetic of Atopic Dermatitis : An Update

Pathogenesis—Immunopathogenesis

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