Concordance and Transmission of Human Papillomavirus Within Heterosexual Couples Observed Over Short Intervals

Widdice, Lea E.; Ma, Yifei; Jonte, Janet; Farhat, Sepideh; Breland, David J.; Shiboski, Stephen; Moscicki, Anna Barbara

doi:10.1093/infdis/jit018

Cited by 66 publications

(71 citation statements)

References 26 publications

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“…All of those studies also reported higher specificities for the AHPV test, which is supported by our data showing a significantly (P Ͻ 0.001) increased specificity of 96.1% for the AHPV test, compared to 94.9% for the HC2 test (difference, 1.2% [95% CI, 0.87% to 1.48%]). This might be due to the fact that, by measuring mRNA levels, the AHPV assay detects actively infected cells, whereas DNA-based assays such as the HC2 assay do not distinguish between intracellular viral DNA and extracellular viral DNA, which may represent contamination (e.g., with virus particles), as shown previously in transmission studies in young couples (30).…”

Section: Discussionmentioning

confidence: 96%

Head-to-Head Comparison of the RNA-Based Aptima Human Papillomavirus (HPV) Assay and the DNA-Based Hybrid Capture 2 HPV Test in a Routine Screening Population of Women Aged 30 to 60 Years in Germany

Iftner¹,

Becker

Neis³

et al. 2015

J Clin Microbiol

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f Testing for E6/E7 mRNA in cells infected with high-risk (HR) human papillomavirus (HPV) might improve the specificity of HPV testing for the identification of cervical precancerous lesions. Here we compared the RNA-based Aptima HPV (AHPV) assay (Hologic) and the DNA-based Hybrid Capture 2 (HC2) HPV test (Qiagen) to liquid-based cytology (LBC) for women undergoing routine cervical screening. A total of 10,040 women, 30 to 60 years of age, were invited to participate in the study, 9,451 of whom were included in the analysis. Specimens were tested centrally by LBC, the AHPV test, and the HC2 test, and women who tested positive on any test were referred for colposcopy. Genotyping was performed on all HR-HPV-positive samples. Test characteristics were calculated based on histological review. As a result, we identified 90 women with cervical intraepithelial neoplasia grade 2؉ (CIN2؉), including 43 women with CIN3؉. Sensitivity differences between the AHPV test and the HC2 test in detecting CIN2؉ (P ‫؍‬ 0.180) or CIN3؉ (P ‫؍‬ 0.0625) lesions were statistically nonsignificant. Of three CIN3 cases that were missed with the AHPV test, two cases presented lesion-free cones and one had a non-HR HPV67 infection. The specificity (30 years of age.T he cervical cancer mortality rate in Germany has decreased dramatically since the introduction of gynecological screening for cervical cancer in 1971 (1). Annual opportunistic screening is performed by conventional cytology (Pap smear) and is covered by health insurance for women Ն20 years of age. Despite this extensive effort, 4,600 new cases of cervical cancer (and approximately 1,500 deaths attributable to cervical cancer) (2) and 150,000 cases of cervical cancer precursors (cervical intraepithelial neoplasia grade 3 [CIN3]) are diagnosed each year (3). Persistent infections with high-risk (HR) human papillomaviruses (HPVs) have been shown to be causal for the development of cervical precancerous lesions and cancer. This has led to the development and investigation of various HPV detection methods, and HR HPV testing in addition to cytology is now widely applied in cervical cancer screening programs (4-7). Three DNA-based and one RNAbased assay for HR HPV group detection and two HPV16/18 genotyping assays have been approved by the U.S. Food and Drug Administration (FDA) for cervical cancer screening (http://www.fda.gov /MedicalDevices/ProductsandMedicalProcedures/InVitroDiagnostics /ucm330711.htm). These assays include the Digene Hybrid Capture 2 (HC2) high-risk ...

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Section: Discussionmentioning

confidence: 96%

Head-to-Head Comparison of the RNA-Based Aptima Human Papillomavirus (HPV) Assay and the DNA-Based Hybrid Capture 2 HPV Test in a Routine Screening Population of Women Aged 30 to 60 Years in Germany

Iftner¹,

Becker

Neis³

et al. 2015

J Clin Microbiol

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“…Transmission from man to woman or woman to man has been evaluated in six of the recent studies shown in Table 1. Three of the studies have detected that transmission of α-HPV occurs more likely from man to woman [4, 19, 20] and two from woman to man [16, 17]. The only study detecting β- and γ-HPV infection within a 6-week follow-up, so far, has not found any difference in transmission between sexes [6].…”

Section: Hpv Transmission In Heterosexual Couplesmentioning

confidence: 99%

“…According to 13 case reports or case series and 9 larger population-based retrospective studies, a small trend of increased risk was found (1–3%). Higher concordance rates have also been related to short abstinence times before sampling [6, 16]. …”

Section: Risk Factors For Hpv Concordance In Heterosexual Couplesmentioning

confidence: 99%

HPV Infections in Heterosexual Couples: Mechanisms and Covariates of Virus Transmission

Kero

Rautava

2019

Acta Cytologica

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Sexual intercourse is regarded as the primary route of human papillomavirus (HPV) transmission. Reported rates of the genotype-specific genital concordance of HPV infection among heterosexual partners vary. Most studies have evaluated only male/female genital transmission, but lately, the oral region has gained interest because of a rising trend of HPV-associated oropharyngeal cancer. Risk factors for type-specific concordance have been reported as an increasing number of younger couples, persistent HPV infection, higher frequency of sexual intercourse, rising number of spouse’s lifetime sexual partners, and sexual relations with prostitutes. However, the concordance of the same genital HPV genotype does not absolutely mean that it has been transmitted by the current partner. There are also other possible non-sexual transmission routes. The detected HPV infection may also be a reactivation of a previous infection. The high complexity of HPV transmission dynamics within an individual him-/herself as well as within sexual couples is discussed in this article.

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“…HPV DNA has been detected from the hand and finger nails of sexually active individuals. 12,13 Since these studies are based on DNA detection and not confirmation of active infections, it is unknown whether these HPV DNA detections reflect live viral particles which can be transmitted. A recent study of 14-to 17-year-old girls reported that HPV DNA was detected in 10 of 22 girls from vaginal swabs prior to reporting vaginal intercourse.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infections in Nonsexually Active Perinatally HIV Infected Children

Moscicki

Puga

Farhat

et al. 2014

AIDS Patient Care and STDs

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Although human papillomavirus (HPV) infections are common in HIV-infected adults, little is known about children. Our objective was to examine the prevalence of and risks for HPV of the oral mucosal and external genital areas in nonsexually active (NSA) perinatally (P) HIV + children and compare with HIV-exposed but uninfected (HEU) children. A convenience sample attending a pediatric clinic were enrolled. Samples for HPV were obtained from the oral and anogenital areas and tested for one of 37 HPV types. The mean age of the 48 PHIV + children was 14.3 -3.9 years vs. 6.2 -4.8 for the 52 HEU ( p < 0.001). Of the 23 PHIV + girls, 30.4% had anogenital and 17% had oral HPV, and of the 27 HEU girls, 2 (7.4%) anogenital and 0 had oral HPV. Of the boys, 4/23 (17.4%) and 1/25 (4%) PHIV + had anogenital and oral HPV, respectively, and 3/24 (12.5%) and 1/25 (4%) HEU had anogenital and oral HPV, respectively. Rates of HPV did not differ by age among the PHIV + , whereas older HEU were more likely to have HPV than younger HEU ( p = 0.07). This large age gap precluded statistical comparison by HIV status. The presence of HPV in NSA PHIV + children may have implications regarding HPV vaccination efficacy.

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Concordance and Transmission of Human Papillomavirus Within Heterosexual Couples Observed Over Short Intervals

Abstract: High rates of concordance shortly after intercourse suggest that some DNA detections in the genital area are contaminants from a partner and not established HPV infections. Female-to-male transmission appeared more common than male-to-female transmission.

Cited by 66 publications

References 26 publications

Head-to-Head Comparison of the RNA-Based Aptima Human Papillomavirus (HPV) Assay and the DNA-Based Hybrid Capture 2 HPV Test in a Routine Screening Population of Women Aged 30 to 60 Years in Germany

Head-to-Head Comparison of the RNA-Based Aptima Human Papillomavirus (HPV) Assay and the DNA-Based Hybrid Capture 2 HPV Test in a Routine Screening Population of Women Aged 30 to 60 Years in Germany

HPV Infections in Heterosexual Couples: Mechanisms and Covariates of Virus Transmission

Human Papillomavirus Infections in Nonsexually Active Perinatally HIV Infected Children

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