2024
DOI: 10.1111/hepr.14011
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Concordance between metabolic dysfunction‐associated steatotic liver disease and nonalcoholic fatty liver disease

Keito Suzuki,
Nobuharu Tamaki,
Masayuki Kurosaki
et al.

Abstract: AimA multisociety consensus group proposed a new nomenclature for metabolic dysfunction‐associated steatotic liver disease (MASLD). Although patients with nonalcoholic fatty liver disease (NAFLD) are expected to be reclassified as patients with MASLD under the new nomenclature, the concordance between MASLD and NAFLD remains unclear. Moreover, waist circumference could be adjusted by ethnicity for diagnosing MASLD; however, there are limited data on the optimal waist circumference in the Japanese population.Me… Show more

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Cited by 14 publications
(7 citation statements)
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“…3 As noted, the concordance between MASLD and NAFLD remains high even with the requirement for a CMR, which is promising given the vast amount of work that has already been completed to understand NAFLD and its' burden. 4,5 Interestingly, these same studies noted that the presence of being overweight or obese is by far the most common CMR among those with MASLD, as well as being a significant and independent predictor for having MASLD. However, it must be noted that the cutoff for meeting the body mass index (BMI) CMR is ≥25 kg/m 2 for non-Asians and ≥23.5 kg/m 2 for Asians, which may miss those that are lean and have not yet developed other co-morbidities, especially those that are younger.…”
mentioning
confidence: 90%
“…3 As noted, the concordance between MASLD and NAFLD remains high even with the requirement for a CMR, which is promising given the vast amount of work that has already been completed to understand NAFLD and its' burden. 4,5 Interestingly, these same studies noted that the presence of being overweight or obese is by far the most common CMR among those with MASLD, as well as being a significant and independent predictor for having MASLD. However, it must be noted that the cutoff for meeting the body mass index (BMI) CMR is ≥25 kg/m 2 for non-Asians and ≥23.5 kg/m 2 for Asians, which may miss those that are lean and have not yet developed other co-morbidities, especially those that are younger.…”
mentioning
confidence: 90%
“… 15 , 16 , 17 , 18 Recent data suggest that almost all patients with NAFLD also have MASLD, and that the clinical impact on cardiovascular risks, extrahepatic comorbidities, and mortality is similar between the two conditions. 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 Therefore, these tests may also be used to identify MASLD in the same manner. However, with the renaming of NAFLD to MASLD, it is not clear whether these indices remain useful considering the new definition of MASLD.…”
Section: Introductionmentioning
confidence: 99%
“…Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), now referred to as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), respectively, are major public health problems associated with obesity and diabetes ( 1 , 2 ). Their complex pathophysiology involves multiple organs and metabolic pathways, challenging diagnosis, risk assessment, and treatment.…”
Section: Introductionmentioning
confidence: 99%